A5013708151- Aquaculture disease management and microbiota
- Animal Virus Infections Studies
- Virus-based gene therapy research
- interferon and immune responses
- Mosquito-borne diseases and control
- Viral Infections and Vectors
- Invertebrate Immune Response Mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- Herpesvirus Infections and Treatments
- Vibrio bacteria research studies
- Virology and Viral Diseases
- Identification and Quantification in Food
- Cytomegalovirus and herpesvirus research
- Antimicrobial Peptides and Activities
- Parasite Biology and Host Interactions
- Animal Disease Management and Epidemiology
- Cassava research and cyanide
- Bacteriophages and microbial interactions
- Immune Response and Inflammation
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Glycosylation and Glycoproteins Research
- Chromium effects and bioremediation
- Iron Metabolism and Disorders
- Toxoplasma gondii Research Studies
Sun Yat-sen University
2015-2025
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2020-2024
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2020-2024
Scale drop and muscle necrosis disease with high mortality widely occurred recently in the hybrid grouper (Epinephelus fuscoguttatus ♀ × E. lanceolatus ♂), a crucial cultured marine fish species China. In this study, 30 Harveyi clade isolates of 27 Vibrio harveyi strains were isolated from diseased groupers south-east north-east coastal areas A total 22 V. determined to be pathogenic, most challenged died within 2 days infection; surviving individuals exhibited scale deep dermal lesions as...
Mandarin fish ranavirus (MRV), a variant of largemouth bass virus (LMBV), is distinct member the genus Ranavirus within family Iridoviridae . Acute MRV infection predominantly affects pyloric caecum, critical visceral organ in mandarin fish, and hypothesized to drive characteristic external clinical sign severe ascites. In this study, we reveal that acute initially targets serosal layer caecum leading rapid progression into fibrinous serositis characterized by hypertrophy, fibrosis,...
Scale drop disease virus (SDDV) is a distinct member in genus Megalocytivirus of family Iridoviridae, garnering increasing attention due to its significant threat teleost. Ferroptosis new type cell death discovered recently and involved various viral infections. Knowledges on SDDV induced ferroptosis remains unclear. Here, we demonstrated that infection triggers ferroptosis, as evidenced by hallmark features such iron overload, massive lipid peroxides accumulation, glutathione depletion...
ABSTRACT Infectious spleen and kidney necrosis virus (ISKNV), the type species of genus Megalocytivirus in family Iridoviridae , causes severe damage to mandarin fish cultures China. Little is known about proteins ISKNV virions. In this study, a total 38 virion-associated were identified by four different workflows with systematic comprehensive proteomic approaches. Among proteins, 21 gel-based (one-dimensional [1-D] two-dimensional [2-D] gel electrophoresis). Fifteen 1-D electrophoresis, 16...
Scale drop disease virus (SDDV), an emerging piscine iridovirus prevalent in farmed Asian seabass Lates calcarifer Southeast Asia, was firstly scientifically descripted Singapore 2015. Here, SDDV isolate ZH-06/20 isolated by inoculating filtered ascites from diseased juvenile yellowfin seabream into MFF-1 cell. Advanced cytopathic effects were observed 6 days post-inoculation. A transmission electron microscopy examination confirmed that numerous virion particles, about 140 nm diameter,...
The genus Megalocytivirus of the family Iridoviridae is composed two distinct species, namely, infectious spleen and kidney necrosis virus (ISKNV) scale drop disease (SDDV), both are important causative agents in a variety bony fish worldwide. Of them, ISKNV species subdivided into three genotypes, red seabream iridovirus (RSIV), ISKNV, turbot reddish body (TRBIV), further six subgenotypes, RSIV-I, RSIV-II, ISKNV-I, ISKNV-II, TRBIV-I, TRBIV-II. Commercial vaccines derived from RSIV-I ,...
Cyprinid herpesvirus 3 (CyHV-3) is the archetypal fish alloherpesvirus and etiologic agent of a lethal disease in common koi carp. To date, genome sequences only four CyHV-3 isolates have been published, but no comparisons biologic properties these strains reported. We sequenced genomes further seven from various geographical sources, compared their growth vitro virulence vivo. The major findings were: (i) existence two genetic lineages previously described as European Asian was confirmed,...