A5100918327- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Nanoplatforms for cancer theranostics
- Pancreatic function and diabetes
- Immunotherapy and Immune Responses
Peking University
2024
Beijing Tian Tan Hospital
2016
Capital Medical University
2016
Scale drop disease virus (SDDV) is a distinct member in genus Megalocytivirus of family Iridoviridae, garnering increasing attention due to its significant threat teleost. Ferroptosis new type cell death discovered recently and involved various viral infections. Knowledges on SDDV induced ferroptosis remains unclear. Here, we demonstrated that infection triggers ferroptosis, as evidenced by hallmark features such iron overload, massive lipid peroxides accumulation, glutathione depletion...
Tumor vaccine therapy offers significant advantages over conventional treatments, including reduced toxic side effects. However, it currently functions primarily as an adjuvant treatment modality in clinical oncology due to limitations tumor antigen selection and delivery methods. vaccines often fail elicit a sufficiently robust immune response against progressive tumors, thereby limiting their efficacy. In this study, we developed nanoparticle-based vaccine, OVA@HA-PEI, utilizing ovalbumin...
Deoxyribonuclease I (DNase I) is an endonuclease responsible for the destruction of chromatin during apoptosis. However, its role in diabetes remains unclear. The aim current study was to investigate DNase combined with high glucose levels β‑cell Human samples were collected and activity examined. High glucose‑cultured INS‑1 cells transfected small interfering RNA (siRNA) cell apoptosis examined by western blotting flow cytometry. Cell viability analyzed Counting Kit‑8 assay. resulting from...