A5103191433- Colorectal Cancer Surgical Treatments
- Metamaterials and Metasurfaces Applications
- Advanced Antenna and Metasurface Technologies
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Gastric Cancer Management and Outcomes
- Photoacoustic and Ultrasonic Imaging
- COVID-19 and healthcare impacts
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Cancer Immunotherapy and Biomarkers
- Pancreatic and Hepatic Oncology Research
- Microwave Engineering and Waveguides
- Millimeter-Wave Propagation and Modeling
- Helicobacter pylori-related gastroenterology studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Immunotherapy and Immune Responses
- Optical Coherence Tomography Applications
- Terahertz technology and applications
- Surgical site infection prevention
- SARS-CoV-2 detection and testing
- Digital Holography and Microscopy
- Autoimmune Neurological Disorders and Treatments
- Multiple and Secondary Primary Cancers
- RNA regulation and disease
Capital Medical University
2019-2024
Beijing Friendship Hospital
2019-2024
Beijing Information Science & Technology University
2021-2024
National Clinical Research Center for Digestive Diseases
2019-2022
Weihai Municipal Hospital
2018-2022
Shandong University
2022
First Affiliated Hospital of Henan University of Traditional Chinese Medicine
2015-2020
Shanghai Jiao Tong University
2018
Peking University
2018
Peking University First Hospital
2018
Abstract Circulating tumor cells (CTCs) is an established biomarker of cancer metastasis. The circulation dynamics CTCs are important for understanding the mechanisms underlying cell dissemination. Although studies have revealed that circadian rhythm may disrupt growth tumors, it generally unclear whether controls release CTCs. In clinical examinations, current in vitro methods detecting blood samples based on a fundamental assumption CTC counts peripheral do not change significantly over...
Nicotinamide phosphoribosyltransferase (NAMPT) possesses various functions in human cells, and altered NAMPT expression is associated with carcinogenesis. The present study detected the of normal cancerous breast tissues from 83 patients using immunohistochemistry, analyzed its association clinicopathological survival data patients. was significantly overexpressed invasive ductal carcinoma compared adjacent mammary gland tissues. Upregulated a larger tumor size, lymph node metastasis,...
It remains controversial whether surgical castration prolongs survival rate and improves therapy prospects in patients suffering from prostate cancer. We used PC3 cell line to establish tumor models. In vivo flow cytometry ultrasonic imaging were monitor the process of cancer growth, development metastasis. found out that number circulating cells (CTCs) orthotopic model was higher than subcutaneous model. The CTC due burst while showed a gradual increase with size. After androgen deprivation...
Abstract Planar metasurface-based quarter wave plates (QWPs) have significant advantages over conventional devices in terms of compactness, flexibility, and simplicity manufacture; however, they offer a relatively narrow operational bandwidth. A broadband terahertz achromatic QWP is realized the 0.68–1.48 THz spectral region this work, which consists several separate metasurface layers dielectric elliptic pillars stacked together with various rotation angles. Meanwhile, an improved simulated...
MicroRNAs can bind with target genes thus inhibiting their expression levels to regulate cell survival, hence serve as serum biomarkers for a variety of purposes.Our aim was explore the role miR-15a-5p in cisplatin/oxaliplatin resistance gastric cancer.In this study, growth and apoptosis cancer lines were measured viability assay flow cytometry, respectively.Dual-luciferase applied miRNA validation.Expression PHLPP2 by quantitative polymerase chain reaction western blot, respectively.Serum...
Cancer metastasis after traditional surgery introduces a high barrier to therapy efficacy. Photodynamic (PDT) for cancer is based on photochemical process of photosensitizers that concentrate in tumors and release oxidant species under light excitation destroy cells. Compared with surgery, PDT provides minimal invasion targeted therapy. In this vivo study, we monitor the real-time long-term dynamics circulating tumor cells (CTCs) single round surgical resection breast animal model. The CTC...
Tumor vaccine therapy offers significant advantages over conventional treatments, including reduced toxic side effects. However, it currently functions primarily as an adjuvant treatment modality in clinical oncology due to limitations tumor antigen selection and delivery methods. vaccines often fail elicit a sufficiently robust immune response against progressive tumors, thereby limiting their efficacy. In this study, we developed nanoparticle-based vaccine, OVA@HA-PEI, utilizing ovalbumin...
Recent preclinical studies have discovered unique synergism between radiotherapy and immune checkpoint inhibitors, which has already brought significant survival benefit in lung cancer. In locally advanced rectal cancer (LARC), neoadjuvant plus inhibitors also achieved surprisingly high pathological complete response (pCR) rates even proficient mismatch-repair patients. As existing researches are all phase 2, single-cohort trials, we aim to conduct a randomised, controlled trial further...
After achieving a clinical complete response through neoadjuvant chemoradiotherapy, nonoperative management approach for rectal cancer patients known as Wait and Watch (W&W) has gained increasing attention. However, the W&W strategy been related to higher local recurrence ambiguous long-term survival. This meta-analysis compared key prognosis indicators between surgical treatment in an effort clarify some long-standing points of confusion.Pubmed, Web Science, EMbase, Cochrane Library were...
Circulating tumor cells (CTCs) play an essential role in metastasis and serve as important prognostic biomarker. The technology of CTC labeling detection vivo can greatly improve the research cancer therapy. However, there is no to detect CTCs clinic. In this study, we demonstrate that 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) amino]-2-deoxy-d-glucose (2-NBDG), a 2-deoxy-glucose analog, work indicate metastases fluorescently by direct intravenous injection. During development implanted mice,...
To assess carcinoembryonic antigen (CEA), carbohydrate 19-9 (CA19-9), platelet distribution width (PDW), neutrophil-to-lymphocyte ratio (NLR), and platelet-lymphocyte (PLR) for gastric cancer's (GC) diagnostic efficiency, the use of receiver operating characteristic curves (ROC) combined with logistic regression to evaluate multi-index combination's value GC. 773 GC patients' clinical data were retrospectively collected in Weihai Municipal Hospital, affiliated hospital Shandong University...
Yao, Hongwei M.D.; Pang, Kai Xiao, Gang Li, Fei Yi Ye, Yingjiang Wang, Xin Xiu, Dianrong Zhenjun Du, Xiaohui Yunfeng Zhou, Lei Chunlian Gu, Jin Zhang, Zhongtao M.D. Author Information
Abstract A major cause of death in cancer patients is distant metastasis tumors, which circulating tumor cells (CTCs) are an important marker. Photoacoustic flow cytometry (PAFC) can monitor CTCs real time, non‐invasively, and label‐free; we built a PAFC system validated the feasibility for monitoring using vivo animal experiments. By cultivating heavily‐pigmented moderately‐pigmented melanoma cells, more were detected mice inoculated with resulting metastases poorer survival status. Tumor...
Fluorouracil implants are widely used in peritoneal interstitial chemotherapy. Curative effects have been obtained, but also caused some complications.We performed an analysis of a 66-year-old male patient's case history, as well conventional pathological and Raman spectroscopic detection the diaphragmatic tumor. We analyzed underlying causes this condition to prevent complications reduce misdiagnoses future cases. The patient had history fluorouracil implantation. Pathological mass revealed...
3611 Background: Several single-arm trials have reported pathological complete response (pCR) rates of 23-50% after combining neoadjuvant radiotherapy with immune checkpoint inhibitors in locally advanced rectal cancer (LARC). We aim to further clarify the efficacy and safety adding PD1 long-course chemoradiation LARC patients this phase 2, randomized, controlled trial. Methods: Patients mid-low, were randomly allocated receive plus concurrent Tislelizumab (experiment group A), or sequential...
Neoadjuvant chemoradiotherapy followed by radical surgery has been a common practice for patients with locally advanced rectal cancer, but the response rate varies among patients. This study aimed to develop ResNet-Vision Transformer based magnetic resonance imaging (MRI)-endoscopy fusion model precisely predict treatment and provide personalized treatment. In this multicenter study, 366 eligible who had undergone neoadjuvant at eight Chinese tertiary hospitals between January 2017 June 2024...