A5033461329- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Cancer-related molecular mechanisms research
- Microbial infections and disease research
- Meat and Animal Product Quality
- Aquaculture disease management and microbiota
- Invertebrate Immune Response Mechanisms
- Genomics and Phylogenetic Studies
- Animal Genetics and Reproduction
- melanin and skin pigmentation
- Genetic diversity and population structure
- Molecular Biology Techniques and Applications
- Mycobacterium research and diagnosis
- Bacteriophages and microbial interactions
- Gut microbiota and health
- Genetic Associations and Epidemiology
- Insect symbiosis and bacterial influences
- Antimicrobial Peptides and Activities
- Animal Disease Management and Epidemiology
- Animal Nutrition and Physiology
- RNA Research and Splicing
- Genetics and Plant Breeding
- Prenatal Screening and Diagnostics
- Aquaculture Nutrition and Growth
- Animal Behavior and Welfare Studies
Jiangxi Agricultural University
2016-2025
Henan Agricultural University
2024
Academy of Military Medical Sciences
2012-2013
Sun Yat-sen University
2007-2009
To investigate population structure, linkage disequilibrium (LD) pattern and selection signature at the genome level in Chinese Western pigs, we genotyped 304 unrelated animals from 18 diverse populations using porcine 60 K SNP chips. We confirmed divergent evolution between pigs showed distinct topological structures of tested populations. acquired evidence for introgression into two pig breeds. Analysis runs homozygosity revealed that historical inbreeding reduced genetic variability...
The Tibetan pig is one of domestic animals indigenous to the Qinghai-Tibet Plateau. Several geographically isolated populations are distributed throughout It remained an open question if these have experienced different demographic histories and evolved independent adaptive loci for harsh environment To address questions, we herein investigated ~ 40,000 genetic variants across genome in a broad panel 678 individuals from 5 geographic 34 lowland breeds.Using series population analyses, show...
Abstract Background Copy number variation (CNV) is a major source of structural variants and has been commonly identified in mammalian genome. It associated with gene expression may present genetic component phenotypic diversity. Unlike many other genomes where CNVs have well annotated, studies porcine CNV diverse breeds are still limited. Result Here we used Porcine SNP60 BeadChip PennCNV algorithm to identify 1,315 putative belonging 565 regions (CNVRs) 1,693 pigs from 18 populations....
Abstract Background Elucidation of the pig transcriptome is essential for interpreting functional elements genome and understanding genetic architecture complex traits such as fat deposition, metabolism growth. Results Here we used massive parallel high-throughput RNA sequencing to generate a high-resolution map porcine mRNA miRNA in liver, longissimus dorsi abdominal from two full-sib F 2 hybrid pigs with segregated phenotypes on growth, blood physiological biochemical parameters,...
Chinese Erhualian is the most prolific pig breed in world. The exhibits exceptionally large and floppy ears. To identify genes underlying this typical feature, we previously performed a genome scan scale White Duroc × cross mapped major QTL for ear size to 2-cM region on chromosome 7. We herein an identical-by-descent analysis that defined within 750-kb region. Historically, large-ear feature has been selected ancient sacrificial culture pigs. By using selective sweep analysis, then refined...
Thousands of QTLs for meat quality traits have been identified by linkage mapping studies, but most them lack precise position or replication between populations, which hinder their application in pig breeding programs. To localize to genomic regions, we performed a genome-wide association (GWA) study using the Illumina PorcineSNP60K Beadchip two swine populations: 434 Sutai pigs and 933 F2 from White Duroc×Erhualian intercross. Meat traits, including pH, color, drip loss, moisture content,...
Genome-wide association studies (GWAS) have been extensively used to identify genomic regions associated with a variety of phenotypic traits in pigs. Until now, most GWAS explored single-trait models. Here, we conducted both single- and multi-trait meta-analysis for nine fatness growth on 2004 pigs from four diverse populations, including White Duroc × Erhualian F2 intercross population Chinese Sutai, Laiwu populations. We identified 44 chromosomal that were the traits, genome-wide...
Abstract Vertnin ( VRTN ) variants have been associated with the number of thoracic vertebrae in European pigs, but association has not evidenced Chinese indigenous pigs. In this study, we first performed a genome-wide study Erhualian pigs using one candidate causative mutation and Illumina Porcine 60K SNP Beadchips. The is significantly vertebral population. We further show that pleiotropic desirable effects on teat carcass (body) length across four diverse populations, including Erhualian,...
Respiratory diseases and its treatments are highly concerned in both the pig industry human health. However, composition distribution of antibiotic resistance genes (ARGs) swine lower respiratory tract microbiome remain unknown. The relationships ARGs with mobile genetic elements (MGEs) lung health unclear. Here, we characterize resistomes containing 1228 open reading frames belonging to 372 using 745 metagenomes from 675 experimental pigs. Twelve conferring tetracycline related an MGE Tn916...
High-quality whole-genome resequencing in large-scale pig populations with pedigree structure and multiple breeds would enable accurate construction of haplotype robust selection-signature detection. Here, we sequence 740 pigs, combine 149 our previously published data, retrieve 207 datasets, form a panel worldwide distributed wild boars, aboriginal highly selected pigs structures, amounting to 1096 genomes from 43 breeds. Combining their haplotype-informative reads structure, accurately...
The number of vertebrae is an economically important trait that affects carcass length and meat production in pigs. A major quantitative locus (QTL) for thoracic vertebral has been repeatedly identified on pig chromosome (SSC) 7. To dissect the genetic basis locus, we herein genotyped a large sample animals from 3 experimental populations Chinese Western origins using 60K DNA chips. Genome-wide association studies consistently across mapped to 947-Kb region SSC7. An identical-by-descent...
Recently, genome-wide association studies (GWAS) have been reported on various pig traits. We performed a GWAS to analyze 22 traits related growth and fatness two populations: White Duroc × Erhualian F2 intercross population Chinese Sutai half-sib population.We identified 14 39 loci that displayed significant associations with at the level chromosome-wide level, respectively. The strongest was between 750 kb region SSC7 (SSC for Sus scrofa) backfat thickness first rib. This had pleiotropic...
Wild boars inhabit diverse climates, including frigid regions like Siberia, but their migration history and cold adaptation mechanisms into high latitudes remain poorly understood. We constructed the most comprehensive wild boar whole-genome variant dataset to date, comprising 124 samples from tropical zones, among which 47 Russian, 8 South Chinese 3 Vietnamese were newly supplemented. also gathered 75 high-quality RNA-seq datasets 10 tissues of 6 Russia southern China. Demographic analysis...
Evolutionary studies of wild and domestic organisms have yielded fascinating discoveries, while the species diversity domestication ducks remain unclear. Here, we assembled eight chromosome-level Anas genomes, combined with Pekin duck genome, to investigate evolution domestication. We found that, compared autosomes, Z chromosome was less affected by introgression exhibited relatively stable local phylogenies. From perspective, proposed that speciation platyrhynchos zonorhyncha accompanied...