A5102993299- Aquaculture disease management and microbiota
- Vibrio bacteria research studies
- RNA modifications and cancer
- Neurological disorders and treatments
- Bacteriophages and microbial interactions
- Iron Metabolism and Disorders
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Neural dynamics and brain function
- Chromium effects and bioremediation
- Cassava research and cyanide
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Bacterial biofilms and quorum sensing
- Neuroscience and Neuropharmacology Research
- Immune cells in cancer
- Neuroscience and Neural Engineering
- Piperaceae Chemical and Biological Studies
- Invertebrate Immune Response Mechanisms
- Ginger and Zingiberaceae research
- Histone Deacetylase Inhibitors Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Aquaculture Nutrition and Growth
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
Sun Yat-sen University
2020-2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2020-2024
Zhujiang Hospital
2020-2024
Southern Medical University
2020-2024
Third Affiliated Hospital of Sun Yat-sen University
2021
Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai)
2020
Second Affiliated Hospital of Jilin University
2019-2020
Yangzhou University
2020
Jimei University
2018-2019
University of Manitoba
2012
Bacterial pathogen-host interactions are highly dynamic, regulated processes that have been primarily investigated using in vitro assays. The dynamics of bacterial interplay vivo poorly understood. Using time-resolved dual RNA-seq a Pseudomonas plecoglossicida-Epinephelus coioides infection model, we observed genes encoding classical virulence factors and host involved immune regulation were dynamically expressed during infection. network inferencing, able to predict interspecies regulatory...
Pseudomonas plecoglossicida is an important pathogen for aquaculture and causes high mortality in various marine fishes. Expression of sigX was found significantly up-regulated at 18°C than 28°C, which verified by quantitative real-time PCR (qRT-PCR). RNAi reduced the content mRNA P. plecoglossicida, whether vitro or spleen all sampling time points. Compared with wild-type strain, infection sigX-RNAi strain resulted onset delay, 20% reduction Epinephelus coioides, as well alleviates symptoms...
Most studies on electrophysiology have not separated aperiodic activity from the spectra but rather evaluated a combined periodic oscillatory component and component. As understanding of gradually deepens, its potential physiological significance has acquired increased appreciation. Herein, we investigated two components in scalp electroencephalogram 16 healthy controls 15 patients with Parkinson's disease (PD); results revealed that parameters were approximately symmetrically distributed...
Abstract MALAT1-associated small cytoplasmic RNA (mascRNA) is a tRNA-like derived from nucleus-located long noncoding (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). While MALAT1 was extensively studied and found to function in multiple cellular processes, including tumorigenesis tumor progression, the role of mascRNA largely unknown. Here we show that upregulated cancer cell lines hepatocellular carcinoma (HCC) clinical samples. Using HCC cells as model, its parent...
N6-methyladenosine (m6A) RNA methylation has emerged as an important factor in various biological processes by regulating gene expression. However, the dynamic profile, function and underlying molecular mechanism of m6A modification during skeletal myogenesis remain elusive. Here, we report that members core methyltransferase complex, METTL3 METTL14, are downregulated muscle development. Overexpression either or METTL14 dramatically blocks myotubes formation. Correspondingly, knockdown...
Staphylococcus aureus intramammary infection is one of the most common causes chronic mastitis in dairy cows, whose development may be associated with epigenetic changes expression important host defense genes. This study aimed to construct a genome-wide DNA methylation profile mammary gland Chinese Holstein cows (n=3) following experimentally induced S. mastitis, and explore potential gene regulatory mechanisms affected by during mastitis. was extracted from aureus-positive aureus-negative...
Parkinson’s Disease (PD) is characterized by the temporary alleviation of motor symptoms following electrode implantation (or nucleus destruction), known as microlesion effect (MLE). Electrophysiological studies have explored different PD stages, but understanding electrophysiological characteristics during MLE period remains unclear. The objective was to examine local field potential (LFP) signals in subthalamic (STN) hyperacute (within 2 days) and 1 month post-implantation. 15 patients...
In the present study, Larimichthys crocea and Pseudomonas plecoglossicida were selected as a host-pathogen interaction model for teleosts prokaryotic pathogens. Five shRNAs designed synthesized to silence fliA gene, all of which resulted in pronounced reductions mRNA; mutant strain with best silencing efficiency 92.16% was chosen subsequent analysis. A significant decrease motility, intracellular survival escape observed fliA-RNAi P. plecoglossicida, whereby gene led 30% mortality four-day...
Neuroinflammation is associated with the pathogenesis of all types neurological disease, in which microglial cells play a critical role. In response to disturbances microenvironment, microglia (MG) become activated and differentiate into either an M1 phenotype, has proinflammatory damaging effect, or M2 plays anti-inflammatory reparative Thus, modulating polarization suitable strategy treat neuroinflammatory disorders. Glial cell-derived neurotrophic factor (GDNF) mediator that exerts...
Abstract Pseudomonas plecoglossicida ( P. ) is a pathogen in aquaculture that causes considerable economic loss. According to artificial infection experiments, the fish were classified into control group, moribund and survival group. Compared both group of had fewer red blood cells (RBCs) lower oxygen saturation (SaO 2 ). Furthermore, has more RBCs SaO compared The concentrations total iron, ferrous ferric mineralized iron spleen groups those Additionally, these components higher than...
Subarachnoid hemorrhage (SAH) patients' surgery is performed to prevent extravasation of blood into the subarachnoid space. Cerebral vasospasm (CVS; narrowing cerebral arteries) occurs following SAH and represents a major cause associated mortality morbidity. To improve postsurgery care patients their prognosis, ability predict CVS onset critical. We report long noncoding RNA (lncRNA) signature distinguish with from without CVS. Cerebrospinal fluid (CSF) was obtained (n = 10) 10). lncRNAs...
Pseudomonas plecoglossicida is a pathogen in aquaculture that causes considerable economic loss. Artificial infection experiments showed the outbreak of disease occurred at 2 days post (dpi), and few fish survived after 7 dpi. Accordingly, injected with phosphate buffered saline (PBS) were classified as control group. The moribund infected P. dpi survival Compared to group, group had fewer red blood cells (RBCs), lower oxygen saturation (SaO2). more RBCs, higher SaO2. total iron...