A5100749309- interferon and immune responses
- Ubiquitin and proteasome pathways
- Plant Stress Responses and Tolerance
- Photosynthetic Processes and Mechanisms
- NF-κB Signaling Pathways
- Cytokine Signaling Pathways and Interactions
- Endoplasmic Reticulum Stress and Disease
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Immune Cell Function and Interaction
- RNA regulation and disease
- Cancer, Hypoxia, and Metabolism
- Plant Gene Expression Analysis
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
- Phagocytosis and Immune Regulation
- Cell death mechanisms and regulation
- Immune Response and Inflammation
- Fibroblast Growth Factor Research
- Retinal Diseases and Treatments
- Toxin Mechanisms and Immunotoxins
- Genomics and Phylogenetic Studies
- Kruppel-like factors research
- Atherosclerosis and Cardiovascular Diseases
- Epigenetics and DNA Methylation
Jiangsu University
2024-2025
Jintan People's Hospital
2025
South China University of Technology
2020-2025
Shenzhen University
2024
Union Hospital
2024
Huazhong University of Science and Technology
2024
The 180th Hospital of PLA
2023-2024
Anhui Agricultural University
2020-2023
State Key Laboratory of Biotherapy
2019-2023
Sichuan University
2019-2023
<h3>Background</h3> Regulatory B (Breg) cells represent one of the cell subsets that infiltrate solid tumors and exhibit distinct phenotypes in different tumor microenvironments. However, phenotype, function clinical relevance Breg human hepatocellular carcinoma (HCC) are presently unknown. <h3>Methods</h3> Flow cytometry analyses were performed to determine levels, functions TIM-1<sup>+</sup>Breg samples from 51 patients with HCC. Kaplan-Meier plots for overall survival disease-free...
During RNA virus infection, the adaptor protein MAVS recruits TRAF3 and TRAF6 to form a signalosome, which is critical induce production of type I interferons (IFNs) proinflammatory cytokines. While activation MAVS/TRAF3/TRAF6 signalosome well studied, negative regulation remains largely unknown. Here we report that viruses specifically promote deubiquitinase OTUD1 expression by NF-κB-dependent mechanisms at early stage viral infection. Furthermore, upregulates levels intracellular Smurf1...
Abstract Linear ubiquitination is a critical regulator of inflammatory signaling pathways. However, linearly ubiquitinated substrates and the biological significance linear incompletely understood. Here, we show that STAT1 has at Lys511 Lys652 residues in intact cells, which inhibits binding to type-I interferon receptor IFNAR2, thereby restricting activation resulting homeostasis. removed rapidly by OTULIN upon stimulation, facilitates interferon-STAT1 signaling. Furthermore, viruses induce...
Abstract MALAT1-associated small cytoplasmic RNA (mascRNA) is a tRNA-like derived from nucleus-located long noncoding (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). While MALAT1 was extensively studied and found to function in multiple cellular processes, including tumorigenesis tumor progression, the role of mascRNA largely unknown. Here we show that upregulated cancer cell lines hepatocellular carcinoma (HCC) clinical samples. Using HCC cells as model, its parent...
Abstract Dehydration responsive element binding protein (DREB) is a significant transcription factor class known to be implicated in abiotic stresses. In this study, we systematically conducted genome-wide identification and expression analysis of the DREB gene family, including structures, evolutionary relationships, chromosome distribution, conserved domains, patterns. A total 65 family members were identified Chinese cabbage ( Brassica rapa L.) classified into five subgroups based on...
Carotid atherosclerosis is a chronic inflammatory disease, which major cause of ischemic stroke. The purpose this study was to analyze the relationship between carotid and novel markers, including platelet lymphocyte ratio (PLR), neutrophil (NLR), monocyte (LMR), (PNR), (NLPR), systemic immune-inflammation index (SII), inflammation response (SIRI), aggregate (AISI), in order find best predictor atherosclerosis.
To explore the differential gene expression in peripheral blood immune cells of individuals with type 2 diabetes mellitus (DM), comparing those and without non-proliferative diabetic retinopathy (NPDR). From a pool 126 potential participants, 60 were selected for detailed analysis. This group included 12 healthy donors (HDs), 22 DM, 26 NPDR. We analyzed mononuclear (PBMCs) using RNA sequencing quantitative PCR (qPCR) to pinpoint differentially expressed genes (DEGs). Western blot flow...
Sestrin-2 (SESN2) is involved in the cellular response to different stress conditions. However, function of SESN2 cardiovascular system remains unknown. In present study, we tested whether has a beneficial effect on vascular endothelial damage induced by angiotensin II (AngII). Firstly, found that AngII induces expression human umbilical vein cells (HUVECs) time-dependent and dose-dependent manner. We also knockdown using small RNA interference promotes toxicity AngII, as well reduction cell...
STAT1 is a critical transcription factor for regulating host antiviral defenses. activation largely dependent on phosphorylation at tyrosine 701 site of (pY701-STAT1). Understanding how pY701-STAT1 regulated by intracellular signaling remains major challenge. Here we find that the form ubiquitinated-STAT1 induced interferons (IFNs). While total relatively stable during early stages IFNs signaling, can be rapidly downregulated ubiquitin-proteasome system. Moreover, ubiquitinated located...
Wheat production is largely restricted by adverse environmental stresses. Under many undesirable conditions, endoplasmic reticulum (ER) stress can be induced. However, the physiological and molecular responses of wheat to ER remain poorly understood. We used dithiothreitol (DTT) tauroursodeoxycholic acid (TUDCA) induce or suppress in cells, respectively, with aim reveal background using a combined approach transcriptional profiling morpho-physiological characterization.To understand...
Tropomyosin receptor kinases (TrkA, TrkB, and TrkC) are attractive therapeutic targets for multiple cancers. Two first-generation small-molecule Trks inhibitors, larotrectinib entrectinib, have just been approved to use clinically. However, the drug-resistance mutations of already emerged, which calls new-generation inhibitors. Herein, we report structural optimization structure–activity relationship studies 6,6-dimethyl-4-(phenylamino)-6H-pyrimido[5,4-b][1,4]oxazin-7(8H)-one derivatives as...
Abstract Ataxin-3 (ATXN3) belongs to the Josephin family of deubiquitinases. So far, ATXN3 is majorly linked neurodegenerative disease, Machado–Joseph disease. The role in antiviral function has not been explored, and vivo deubiquitinating activity remains largely unknown. In this study, we report that an important positive regulator type I IFN (IFN-I)–mediated murine primary lung cells human epithelial fibroblast cell lines. We clarify does promote IFN-I production, but enhances...
The Traf2- and Nck-interacting protein kinase (TNIK) is a downstream signal of the Wnt/β-catenin pathway has been thought as potential target for treatment colorectal cancer (CRC) that often associated with dysregulation signaling pathway. Herein, we report discovery series 3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one derivatives new class TNIK inhibitors. Structure–activity relationship (SAR) analyses led to identification number potent inhibitors compound 21k being most active one (IC50:...
Abstract Small-airway remodelling is one of the most remarkable pathological features chronic obstructive pulmonary disease (COPD), in which angiogenesis plays a critical role that contributes to progression. The endothelial cell-specific mitogen vascular growth factor (VEGF), as well its receptors, VEGFR1, VEGFR2, are thought be major mediators angiogenesis, and sunitinib exhibits anti-angiogenesis property through VEGF blockage has been widely used treat various cancers. In our study,...
Chlorophyll (Chl) is a vital photosynthetic pigment involved in capturing light energy and conversion. In this study, the color conversion of inner-leaves from green to yellow new wucai (Brassica campestris L.) cultivar W7-2 was detected under low temperature. The displayed normal leaf phenotype at seedling stage, but inner leaves gradually turned when temperature decreased 10 °C/2 °C (day/night), This study facilitates us understand physiological molecular mechanisms underlying changes...
The Josephin domain-containing (JOSD) protein 1 (JOSD1) is recognized as one member of deubiquitinases (DUBs) due to its catalytic "Josephin" domain. However, the in vivo deubiquitinating activity JOSD1 remains unidentified, and biological functions are largely unknown. In this study, we report that plays an important role regulating type-I interferon (IFN-I)-mediated antiviral activity. physically interacts with SOCS1, which essential negative regulator many cytokines signaling, enhances...
CREB-binding protein (CBP) participates in numerous transcription events. However, cell-intrinsic inhibitors of CBP are poorly defined. Here, we found that cellular USP12 interacts with the HAT domain and inhibits CBP's acetyltransferase activity. Interestingly, positively regulates interferon (IFN) antiviral signaling independently its deubiquitinase Furthermore, IFN translocates from cytoplasm to nucleus. The decrease cytoplasmic facilitates CBP-induced acetylation activation proteins...
Abstract Background Wucai ( Brassica campestris L. ssp. chinensis var. rosularis Tsen) is a cold-tolerant plant that vulnerable to high temperature. This study explored the response mechanism of wucai low In this study, seedlings were treated with different temperatures, including temperature (LT), (HT), and control. Results According transcriptomics analysis, number differentially expressed genes (DEGs) in HT LT was 10,702 7267, respectively, compared The key associated physiological...