A5101959466- interferon and immune responses
- Ubiquitin and proteasome pathways
- NF-κB Signaling Pathways
- Autophagy in Disease and Therapy
- Cytokine Signaling Pathways and Interactions
- Respiratory and Cough-Related Research
- Pneumonia and Respiratory Infections
- Mobile Ad Hoc Networks
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- Opportunistic and Delay-Tolerant Networks
- RNA regulation and disease
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Wastewater Treatment and Nitrogen Removal
- Caching and Content Delivery
- Microbial Fuel Cells and Bioremediation
- COVID-19 Clinical Research Studies
- Nuclear Receptors and Signaling
- Polysaccharides and Plant Cell Walls
- COVID-19 diagnosis using AI
- Lung Cancer Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Hepatitis B Virus Studies
- Neonatal Respiratory Health Research
Hangzhou DAC Biotech (China)
2024
South China University of Technology
2024
Qingdao University
2023-2024
Mindray (China)
2024
Affiliated Hospital of Qingdao University
2023-2024
Taizhou University
2022-2023
Union Hospital
2020-2022
Huazhong University of Science and Technology
2020-2022
Changchun University of Chinese Medicine
2020-2021
Soochow University
2016-2020
During RNA virus infection, the adaptor protein MAVS recruits TRAF3 and TRAF6 to form a signalosome, which is critical induce production of type I interferons (IFNs) proinflammatory cytokines. While activation MAVS/TRAF3/TRAF6 signalosome well studied, negative regulation remains largely unknown. Here we report that viruses specifically promote deubiquitinase OTUD1 expression by NF-κB-dependent mechanisms at early stage viral infection. Furthermore, upregulates levels intracellular Smurf1...
Abstract Linear ubiquitination is a critical regulator of inflammatory signaling pathways. However, linearly ubiquitinated substrates and the biological significance linear incompletely understood. Here, we show that STAT1 has at Lys511 Lys652 residues in intact cells, which inhibits binding to type-I interferon receptor IFNAR2, thereby restricting activation resulting homeostasis. removed rapidly by OTULIN upon stimulation, facilitates interferon-STAT1 signaling. Furthermore, viruses induce...
Steroid-induced osteonecrosis of the femoral head (ONFH) is a common and devastating bone disorder, which often results in progressive collapse subsequent osteoarthritis. The proliferation ability osteogenic differentiation marrow mesenchymal stem cells (BMSCs) play critical roles maintaining structural functional integrity to prevent ONFH. Until now, little has been known about underlying mechanism BMSCs disorder during ONFH progression. Circular RNAs (circRNAs) are considered be vital...
STAT1 is a critical transcription factor for regulating host antiviral defenses. activation largely dependent on phosphorylation at tyrosine 701 site of (pY701-STAT1). Understanding how pY701-STAT1 regulated by intracellular signaling remains major challenge. Here we find that the form ubiquitinated-STAT1 induced interferons (IFNs). While total relatively stable during early stages IFNs signaling, can be rapidly downregulated ubiquitin-proteasome system. Moreover, ubiquitinated located...
The present study focuses on the neuroprotective effect of glycyrrhizic acid (GA, a major compound separated from Glycyrrhiza Radix, which is crude Chinese traditional drug) against glutamate-induced cytotoxicity in differentiated PC12 (DPC12) cells. results showed that GA treatment improved cell viability and ameliorated abnormal alterations mitochondria DPC12 reversed glutamate-suppressed B-cell lymphoma 2 levels, inhibited glutamate-enhanced expressions Bax cleaved caspase 3, reduced...
The Josephin domain-containing (JOSD) protein 1 (JOSD1) is recognized as one member of deubiquitinases (DUBs) due to its catalytic "Josephin" domain. However, the in vivo deubiquitinating activity JOSD1 remains unidentified, and biological functions are largely unknown. In this study, we report that plays an important role regulating type-I interferon (IFN-I)-mediated antiviral activity. physically interacts with SOCS1, which essential negative regulator many cytokines signaling, enhances...
CREB-binding protein (CBP) participates in numerous transcription events. However, cell-intrinsic inhibitors of CBP are poorly defined. Here, we found that cellular USP12 interacts with the HAT domain and inhibits CBP's acetyltransferase activity. Interestingly, positively regulates interferon (IFN) antiviral signaling independently its deubiquitinase Furthermore, IFN translocates from cytoplasm to nucleus. The decrease cytoplasmic facilitates CBP-induced acetylation activation proteins...
Objectives Normal commitment of the endoderm third pharyngeal pouch (3PP) is essential for development and differentiation thymus. The aim this study was to investigate role transcription factor HOXA3 in 3PP (3PPE) from human embryonic stem cells (hESCs). Methods 3PPE differentiated hESC-derived definitive (DE) by mimicking developmental queues with Activin A, WNT3A, retinoic acid BMP4. function assessed further differentiating into functional thymic epithelial (TECs). effect inhibition on...
Microtubules are essential components of the cytoskeleton that participate in a variety cellular processes such as cell division and migration. In addition, there is growing body evidence implicating role for microtubules intracellular viral transport. this study, we found pharmacological disruption remarkably blocked bovine immunodeficiency virus (BIV) movement from periphery to perinuclear region, process known retrograde A similar effect was observed by inhibiting function...
Syntaxin 5 (STX5) is a member of the syntaxin or target-soluble SNAP receptor (t-SNARE) family and plays critical role in autophagy. However, its function molecular mechanism tumor cell migration are still unknown. The STX5 influencing hepatocellular carcinoma (HCC) an important topic our research.By using quantitative reverse transcription polymerase chain reaction (qPCR), western blotting, immunohistochemical analysis RNA protein tissues, we comprehensively evaluated data sets from public...
It is well known that autophagy serves a crucial role in renal tubular epithelial cell (RTEC) injury the pathogenesis of chronic kidney disease (CKD). The accumulation advanced oxidation protein products (AOPPs) also participates progression CKD. However, effects AOPPs on remain unknown. To clarify underlying mechanism RTEC CKD, effect HK-2 cells, an line, was investigated. results present study revealed AOPP exposure downregulated expression B-cell lymphoma-2-interacting myosin-like...
Objective: Diffusion-weighted imaging (DWI)-Alberta Stroke Program Early CT Score (ASPECTS) is a simple, widely used method to estimate the size of infarct. Our aim determine whether there relationship between DWI-ASPECTS and fluid-attenuated inversion recovery (FLAIR) vascular hyperintensity (FVH)-DWI mismatch better quantify FVH-DWI assess prognosis cerebral infarction. Materials Methods: A retrospective analysis 109 patients with MCA stenosis or occlusion infarction was performed by...
Streptococcus pneumoniae (S. pneumoniae) is an opportunistic pathogen that causes pneumonia, meningitis and bacteremia in humans animals. Pneumolysin (PLY), a major pore-forming toxin important for S. pathogenicity, promising target the development of anti-infective agents. Ephedra sinica granules (ESG) one oldest medical preparation with multiple biological activities (such as divergent wind cold effect); however, detailed mechanism remains unknown. In this study, we found ESG treatment...
Putting forward an efficient routing algorithm in DTN (delay tolerant network) has become a focus of attention due to the existing phenomena that connections between nodes network change dramatically over time and communications suffer from frequent disruptions. In this paper, meeting span is predicted using Markov model, relay node holding shortest with destination determined as most node. two phases, spray phase wait phase, message routed according utility value. Thus, based on prediction...
Mesenchymal stem cell (MSC) transplantation may serve as an important treatment modality in chronic kidney disease (CKD); however, the underlying mechanisms remain unclear. Advanced oxidation protein products (AOPP) have been demonstrated to induce renal tubular epithelial (RTEC) injury via autophagy inhibition. Therefore, present study was performed investigate role of human umbilical cord‑derived MSCs (hUC‑MSCs) RTEC autophagy. AOPP‑treated HK‑2 cells were co‑cultured with hUC‑MSCs or...
Since communication devices are carried by people in a great number of delay tolerant networks, networks one kind social to some extent. Analyzing properties has become an important issue designing efficient routing protocols. In this paper, more accurate and comprehensive metric for detecting the quality relationships between nodes is proposed considering contact time, frequency regularity. Then overlapping hierarchical community detection method designed based on new tree structure built....
Objectives: To present the temporal changes of CT manifestations in COVID-19 patients from a single fangcang shelter hospital and to facilitate understanding disease course. Materials Methods: This retrospective study included 98 (males: females, 43:55, mean year, 49±12 years) with confirmed at Jianghan admitted between Feb 05, 2020, 09, who had initial chest CTs our hospital. Radiographic features scores were analyzed. Results: A total 267 scans evaluated. Our showed high median score 7...