A5100604996- Autophagy in Disease and Therapy
- CAR-T cell therapy research
- Perovskite Materials and Applications
- Occupational Health and Safety Research
- Quantum Dots Synthesis And Properties
- Disaster Response and Management
- SARS-CoV-2 and COVID-19 Research
- Patient Safety and Medication Errors
- Foreign Body Medical Cases
- Biosimilars and Bioanalytical Methods
- Chemotherapy-induced cardiotoxicity and mitigation
- Inflammasome and immune disorders
- Clinical Nutrition and Gastroenterology
- Advanced Glycation End Products research
- COVID-19 and Mental Health
- Extracellular vesicles in disease
- Polyomavirus and related diseases
- Mental Health Treatment and Access
- Phytochemical Studies and Bioactivities
- Water Resources and Sustainability
- Occupational Health and Performance
- Philippine History and Culture
- Architecture and Cultural Influences
- Metabolomics and Mass Spectrometry Studies
- Environmental Impact and Sustainability
Chinese Academy of Agricultural Sciences
2022-2025
Shanxi Medical University
2023-2024
Shanxi Academy of Medical Sciences
2023-2024
Guangzhou Medical University
2024
China University of Geosciences (Beijing)
2024
Nanjing Drum Tower Hospital
2023-2024
Qingdao Agricultural University
2019
Zhujiang Hospital
2018
Southern Medical University
2018
University of Pittsburgh
2015
Mitochondria, which is essential for adequate innate immune response, energy metabolism and mitochondria reactive oxygen species (ROS) production, might be in the cross fire of Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) host cell defense. However, little known about interactions between SARS-CoV-2. We performed fluorescent microscopy found an enrichment SARS-CoV-2 replication products double stranded RNA (dsRNA) within mitochondria. The entry process dsRNA mediated by Tom20...
A one-step dual-additive strategy enables high-quality wide-bandgap perovskite films with efficient defect passivation, resulting in a certified record PCE of 44.72%, high V oc 1.069 V, and an FF 82.3% under U30 light.
This study aims to establish an animal model of monkeypox virus (MPXV) infection in dormice through intranasal inoculation. Male aged 4-5 months were selected as experimental subjects and administered different titers MPXV (103.5 PFU, 104.5 105.5 respectively) via nasal instillation. Within 14 days post-infection, clinical indicators such survival rate, body weight changes, respiratory status, mental state continuously monitored. Additionally, tissue samples from the lungs, liver, spleen,...
Previous studies have shown that irinotecan (CPT‑11) impairs chemotherapy‑induced apoptosis by activating nuclear factor‑κB (NF‑κB) and a number of strategies been employed to augment chemosensitivity through the suppression NF‑κB activation. Berberine, botanical alkaloid, was reported enhance 5‑fluorouracil doxorubicin suppressing In present study, effect berberine on CPT‑11‑induced investigated inhibition NF‑κB. Inhibition activation p65 small interfering RNA potentiate induced CPT‑11....
The emergence of novel Omicron subvariants has raised concerns regarding the efficacy immunity induced by prior breakthrough infection (BTI) or reinfection against current circulating subvariants. Here, we prospectively investigated durability antibody and T cell responses in individuals post BA.2.2 BTI, with without subsequent BA.5 reinfection. Our findings reveal that emerging subvariants, including CH.1.1, XBB, JN.1, exhibit extensive immune evasion previous infections. Notably, level IgG...
We have previously shown that an extracellular matrix (ECM) bioscaffold derived from porcine small intestine submucosa (SIS) enhanced the healing of a gap injury medial collateral ligament as well central third defect patellar tendon. With addition hydrogel form SIS, we found transected goat anterior cruciate (ACL) could also be healed. The result begs research question whether SIS has positive effects on ACL fibroblasts (ACLFs) and thus facilitates healing. In study, ECM-SIS was fabricated...
Abstract Coronavirus disease 2019 is a global pandemic caused by SARS-CoV-2. The emergence of its variant strains has posed considerable challenge to clinical treatment. Therefore, drugs capable inhibiting SARS-CoV-2 infection, regardless virus variations, are in urgently need. Our results showed that the endosomal acidification inhibitor, Bafilomycin A1 (Baf-A1), had an inhibitory effect on viral RNA synthesis SARS-CoV-2, and Beta Delta variants at concentration 500 nM. Moreover, human lung...
This study developed a set of competency evaluation indicators for billing nurses in China.In clinical practice, often take up responsibilities that are accompanied by certain risks. However, the index system has not been established China.This consisted two main phases research design: first phase included literature review and semi-structured interviews. Individual interviews were conducted with 12 departments 15 nurse managers related departments. Concepts distilled from linked to results...
Autophagy plays an important role in the lifecycle of viruses. However, there is currently a lack systematic research on relationship between Infectious Bronchitis Virus (IBV) and autophagy. This study aims to investigate impact IBV autophagy viral replication. We observed that infection increased expression microtubule-associated protein 1 light chain 3, marker autophagy, decreased sequestosome 1, led elevated intracellular LC3 puncta levels. These findings suggest activates autophagic...
In patient safety accidents, nurse managers are indirectly victimized by the pressures from many aspects and become second victim. This study delves into experiences of in China, aiming to uncover their cognition provide reference for relevant managers. A descriptive phenomenological approach was used gain insight inner reality leaders' management perceptions experiencing incidents. The data 15 leaders who experienced incidents Bethune Hospital, Shanxi Province, were collected via...
To assess abusive supervision and organizational silence among nurses investigate the mediating influence of psychological capital fear.
Endoscopic procedures, such as balloon/bougie dilation and stent implantation, have gained increasing potential the treatment of corrosive esophageal stricture. The purpose present retrospective case series study was to assess clinical outcomes endoscopic therapy strictures after caustic injury.Between January 2003 December 2009, 13 admitted patients that developed stricture agent ingestion underwent at First Affiliated Hospital Nanjing Medical University. Data age, gender, agents, site...
Summary Chimeric antigen receptor T cell (CAR‐T) therapy has shown remarkable efficacy in treating advanced B‐cell malignancies by targeting CD19, but antigen‐negative relapses and immune responses triggered murine‐derived antibodies remain significant challenges, necessitating the development of novel humanized multitarget CAR‐T therapies. Here, we engineered a second‐generation 4‐1BB‐CD3ζ‐based CAR construct incorporating CD19 single‐chain variable fragments (scFvs) BAFFR single‐variable...
The North China Plain (NCP) serves as the main grain production land in China, functioning a critical region for ensuring China’s food security. To address multifaceted challenges confronting security NCP, study embarked on comprehensive analysis of synergistic interactions between agricultural water usage, carbon emissions, and ecosystem health. By proposing footprint family indicators using bottom-up IPCC coefficient approach, this quantitatively evaluates spatial–temporal changes...
An on-line HPLC-diode array detection-flow injection chemiluminescence (HPLC-DAD-FICL) method was applied to estimate the difference of Puerariae lobatae and thomsonii. Their chemical active profiles could be obtained by HPLC-DAD-FICL in one run. Seventeen compounds two species were tentatively identified HPLC-electrospray ionization-MS (HPLC-ESI-MS) method. The main antioxidants rapidly screened fingerprints coupled with MS data. Similarity Hierarchical clustering analysis (HCA) used...
It is well known that autophagy serves a crucial role in renal tubular epithelial cell (RTEC) injury the pathogenesis of chronic kidney disease (CKD). The accumulation advanced oxidation protein products (AOPPs) also participates progression CKD. However, effects AOPPs on remain unknown. To clarify underlying mechanism RTEC CKD, effect HK-2 cells, an line, was investigated. results present study revealed AOPP exposure downregulated expression B-cell lymphoma-2-interacting myosin-like...
Elucidation of the cardio-oncologic knowledge among oncology nurses tertiary hospitals in Shanxi Province to provide better insights and directions for management by nursing managers.China's National Health Wellness Commission issued Action Plan Further Improving Nursing Services June 2023, which requires patients with physical mental holistic services, such as medical care, condition observation, assistance treatment, health guidance. Most are treated chemotherapy, but modality can cause...
With decreasing population sizes and fragmentation of the original habitats pteridophytes in Hainan Island, abundance most has been dramatically reduced, some species may be at brink extinction. To assess natural distribution on we conducted three analyses: flora, niche, habitat. Thirty-two endangered 21 families were found accounting for 8% 400 there. Floristic studies showed that 9% these 32 are tropical, 50% tropical Asian, 20% pan-tropical, 3% from East Asia, Southern Hemisphere, 15%...
<title>Abstract</title> <bold>Purpose:</bold> The objective of this study is to gain insight into the psychological experience and present condition nurses who serve as second victims in process restoring sequence events. Additionally, research aims investigate effects events on these victims, propose recommendations justifications for supporting them. <bold>Methods:</bold> An exploratory mixed method was adopted understand emotional victim when passage incident through qualitative research,...
When the nursing department of our hospital checked ward round records head nurse, it was found that some problems could not be during rounds, and most were superficial; Some studies have also managers are only going through motions rounds or unable to identify due a mismatch between their professional competence supervised department, fail superficial deep-seated problems, making quality supervision unsatisfactory.
This article is an investigation of English-language anthologies modern Chinese drama that emerged during the later twentieth century. Since 1970, approximately ten such have been published in anglophone world. These played a critical role constructing as literary genre and projecting image China successful socialist nation. By analysing these terms criteria influenced selection plays, this aims to shed light on how translation contributed (re)construction English-speaking process play...