A5102372610- Plant Molecular Biology Research
- Receptor Mechanisms and Signaling
- Genomics and Chromatin Dynamics
- Plant nutrient uptake and metabolism
- Photosynthetic Processes and Mechanisms
- Neuroendocrine regulation and behavior
- Copper-based nanomaterials and applications
- COVID-19 Clinical Research Studies
- Bacteriophages and microbial interactions
- Advanced Photocatalysis Techniques
- Cancer Genomics and Diagnostics
- Chromosomal and Genetic Variations
- Nutrition and Health in Aging
- Gas Sensing Nanomaterials and Sensors
- Plant Virus Research Studies
- DNA Repair Mechanisms
- RNA Research and Splicing
- Advanced biosensing and bioanalysis techniques
- Plant Reproductive Biology
- Crystallization and Solubility Studies
- Virology and Viral Diseases
- X-ray Diffraction in Crystallography
- Cancer survivorship and care
- Plant Genetic and Mutation Studies
- Health, Environment, Cognitive Aging
Memorial Sloan Kettering Cancer Center
2020-2025
Jiujiang University
2025
Xiangtan University
2024
Center for Life Sciences
2017-2024
Tsinghua University
2017-2024
Nanjing University of the Arts
2024
Fuzhou University
2024
Nanjing University of Chinese Medicine
2021-2023
New York Proton Center
2023
First Affiliated Hospital of Guangzhou Medical University
2020-2021
Heterochromatin Protein 1 (HP1) recognizes histone H3 lysine 9 methylation (H3K9me) through its conserved chromodomain and maintains heterochromatin from fission yeast to mammals. However, in Arabidopsis, Like (LHP1) colocalizes genome-wide with H3K27me3, is the functional homolog of Polycomb protein. This raises question whether genuine HP1 homologs exist plants. Here, we report on discovery ADCP1, a plant-specific triple tandem Agenet protein, as multivalent H3K9me reader establish that...
Maintaining organellar genome integrity is essential for eukaryotic cells, and many factors can threaten integrity. R-loops are DNA:RNA duplexes produced during transcription, with the nontemplated DNA forming a single-stranded region. function in regulation of replication, repair, but also be susceptible to lesions that form double-stranded breaks thus induce instability. From investigating plant chloroplast-localized R-loop removing enzyme AtRNH1C, we have found it responsible plastid...
How distal enhancers physically control promoters over large genomic distances, to enable cell-type specific gene expression, remains obscure. Using single-gene super-resolution imaging and acute targeted perturbations, we define physical parameters of enhancer-promoter communication elucidate processes that underlie target activation. Productive encounters happen at 3D distances δ200 nm - a spatial scale corresponding unexpected enhancer-associated clusters general transcription factor...
Plant mitochondrial genomes undergo frequent homologous recombination (HR). Ectopic HR activity is inhibited by the surveillance pathway, but underlying regulatory mechanism unclear. Here, we show that RNase H1 AtRNH1B impairs formation of RNA:DNA hybrids (R-loops) and participates in pathway Arabidopsis thaliana . suppresses ectopic at intermediate-sized repeats (IRs) thus maintains DNA (mtDNA) replication. The AtRNH1C restricted to chloroplast; however, when cells lack AtRNH1B, transport...
This study aims to establish an animal model of monkeypox virus (MPXV) infection in dormice through intranasal inoculation. Male aged 4-5 months were selected as experimental subjects and administered different titers MPXV (103.5 PFU, 104.5 105.5 respectively) via nasal instillation. Within 14 days post-infection, clinical indicators such survival rate, body weight changes, respiratory status, mental state continuously monitored. Additionally, tissue samples from the lungs, liver, spleen,...
Abstract Prior studies showed that structural loops collapse upon acute cohesin depletion, while regulatory enhancer-promoter (E-P) largely persist, consistent with minimal transcriptional changes. However, these studies, conducted in asynchronous cells, could not resolve whether is required for the establishment of interactions and activation during cell division or state transitions. To address this gap, we degraded RAD21, a core subunit, naïve mouse embryonic stem cells (ESCs)...
Abstract Background Long QT syndrome (LQTS) is a cardiac disorder characterized by prolonged intervals on electrocardiograms (ECG), ventricular arrhythmias, and sudden death. Clinically, two inherited forms of LQTS have been defined: autosomal dominant or Romano-Ward (RWS) not associated with deafness recessive Jervell Lange-Nielsen (JLNS) deafness. Methods A Chinese family both RWS JLNS was identified. Family members were diagnosed based the presence interval as seen 12-lead ECG medical...
Leaf senescence is crucial for crop yield and quality. Transcriptional regulation a key step integrating various senescence-related signals into the nucleus. However, few regulators of implicating transcriptional events have been functionally characterized in wheat. Based on our RNA-seq data, we identified WRKY transcription factor, TaWRKY13-A, that predominately expresses at senescent stages. By using virus-induced gene silencing (VIGS) method, manifested impaired TaWRKY13-A leading to...
To explore the relationship between L3 skeletal muscle index (SMI) and prognosis of patients with stage IV gastric cancer (GC).A total 27 GC requiring chemotherapy admitted to our hospital from 1 April 2015 20 May 2019 were selected as participants. The Kaplan-Meier method was used describe survival time all By evaluating plane CT images, mass (cm2/m2) (including psoas major, erector spinae, quadratus psoas, transversus abdominis, external oblique internal abdominis) calculated study changes...
Chromatin is the genetic material assembled by nucleic acids (including DNA and RNA) proteins. The biological functions of chromatin are highly dependent on interaction between (and/or proteins that bind to it. immunoprecipitation (ChIP) a powerful technique for evaluating these interactions has been widely used characterize nuclear However, its application in identifying plant organellar chromatin-binding lagging. This article describes method analyzing association chloroplast-localized...
Introduction: In this study, a surface-enhanced Raman scattering (SERS) sensor based on functionalized Au/Si cap-cone array (Au/Si CCA) was constructed using the identity-release strategy to detect Vimentin changes during epithelial-mesenchymal transition (EMT) in gastric cancer (GC). Methods: The periodic structure of CCA, which can form "hot spots" with high density and regular arrangement, is substrate excellent performance. CCA aptamers as capture substrate, Au nanocubes (AuNCs) were...
Two novel Polyoxometalates have been constructed by simple hydrothermal synthesis using rare-earth (RE) and antimonotungstates (ATs) {B-α-SbW9O33} as raw materials with the molecular formulas of H4.5Na1.5(H2O)6(C3H5N2)3{Na(Sb3O)2[B-β-SbW8O31Dy(H2O)2]3}·12H2O (1) H9(C3H5N2)5{[Sb6IIISbVDy2WO10(H2O)5][(B-β-SbW9O33)2(B-α-SbW9O33)]}·16H2O (2). X-ray Single crystal diffractometer analysis shows that both 1 2 possess trimer configurations. Polyoxoanion is assembled from three trilacunary...
In media-related experimental content, non-narrative methods utilizing non-verbal elements such as dance, music, and visual effects significantly enhance both narrative emotional resonance. This paper explores how symbolic dance choreography, thematic (e.g., color usage shadow projections) convey intent, heightening viewers' immersion engagement. Beginning with an analysis of the demonstrates abstract movements themes like freedom oppression or states joy despair, revealing mechanisms...