A5076672675- Inflammatory Myopathies and Dermatomyositis
- Cancer Diagnosis and Treatment
- Eosinophilic Disorders and Syndromes
- Tryptophan and brain disorders
- MRI in cancer diagnosis
- Skin Diseases and Diabetes
- Cutaneous lymphoproliferative disorders research
- Bladder and Urothelial Cancer Treatments
- Eating Disorders and Behaviors
- Sarcoma Diagnosis and Treatment
- Lymphoma Diagnosis and Treatment
- Hormonal and reproductive studies
- Sirtuins and Resveratrol in Medicine
- Genetic factors in colorectal cancer
- Dysphagia Assessment and Management
- Nerve injury and regeneration
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Bipolar Disorder and Treatment
- Gastric Cancer Management and Outcomes
- Immunodeficiency and Autoimmune Disorders
- Mathematical Biology Tumor Growth
- Ovarian function and disorders
- Wnt/β-catenin signaling in development and cancer
- Ovarian cancer diagnosis and treatment
- Radiomics and Machine Learning in Medical Imaging
Wenzhou City People's Hospital
2025
Shanghai Jiao Tong University
2015-2023
Shanghai Ninth People's Hospital
2023
Ruijin Hospital
2019-2022
Jiangsu Cancer Hospital
2021
Nanjing Medical University
2021
Senescence of bone marrow mesenchymal stem cells (BMMSCs) induced by chronic oxidative stress is an important factor contributes to the postmenopausal osteoporosis (PMOP). Mitochondrial quality control takes a pivotal role in regulating and cell senescence. Genistein major isoflavone soy products, which best known for its ability inhibit loss both women ovariectomized (OVX) rodents. Here we show that OVX-BMMSCs displayed premature senescence, elevated reactive oxygen species (ROS) level...
Obesity is a complex metabolic disease that serious detriment to both children and adult health, which induces variety of diseases, such as cardiovascular disease, type II diabetes, hypertension cancer. Although adverse effects obesity on female reproduction or oocyte development have been well recognized, its harmfulness male fertility still unclear because reported conflicting results. The aim this study was determine whether diet-induced impairs furthermore uncover underlying mechanisms....
Dermatomyositis (DM) is an autoimmune disease affecting primarily the skin, muscle and lung. Dysregulations of cytokines chemokines are commonly found in inflammatory disorders.To investigate association between serum clinical severity, especially cutaneous lesions interstitial lung (ILD) patients with DM clinically amyopathic (CADM).Clinical features, laboratory findings 40 or CADM were collected analysed. Serum measured by enzyme-linked immunosorbent assay cytometric bead array. A multiple...
<title>Abstract</title> <bold>Objective:</bold> To explore the clinicopathological characteristics and prognosis of orbital alveolar soft part sarcoma (ASPS), providing a basis for its diagnosis treatment. <bold>Methods:</bold> Patients diagnosed with primary ASPS at Zhongshan Ophthalmic Center Sun Yat-sen University from 2014 to 2024 were included. A retrospective analysis clinical data, imaging findings, pathological features, immunohistochemistry results, etc., was conducted. Follow-up...
The anti-melanoma differentiation-associated gene 5 (MDA5) antibody is the main predictor of interstitial lung disease (ILD) in DM and clinically amyopathic (CADM). Nevertheless, a subset MDA5+ patients have favourable prognosis. We aimed to determine possibility using anti-MDA5 isotypes IgG subclasses for evaluating ILD risk.The (IgG, IgA IgM) were detected serum samples 36 anti-MDA5+ with DM/CADM ELISA. antibodies further investigated. Laboratory findings cumulative survival analysed based...
To explore the relationship between L3 skeletal muscle index (SMI) and prognosis of patients with stage IV gastric cancer (GC).A total 27 GC requiring chemotherapy admitted to our hospital from 1 April 2015 20 May 2019 were selected as participants. The Kaplan-Meier method was used describe survival time all By evaluating plane CT images, mass (cm2/m2) (including psoas major, erector spinae, quadratus psoas, transversus abdominis, external oblique internal abdominis) calculated study changes...
Motivation: Conventional axial full-field-of-view (fFOV) DWI poorly demonstrates upper tract urothelial carcinoma (UTUC) due to its varying morphology and anatomical position. The additional coronal reduced field-of-view (rFOV) may improve evaluation. Goal(s): objective of this study was assess the diagnostic value image quality rFOV in evaluation UTUC. Approach: This compared quality, tumor contrast, ADC value, staging accuracy between fFOV Results: Coronal provided better higher contrast...
Motivation: Preoperative evaluation of the consistency pituitary adenomas (PAs) plays a significant role in surgical strategy. However, previous studies concerning assessment tumor PAs were controversial1-4. Goal(s): To evaluate ability continuous-time random-walk (CTRW) diffusion model to predict and extent resection (EOR) PAs. Approach: The CTRW relaxes priori distributions waiting times distance increments water molecular diffusion, providing realistic description complex structures...
Accurately determining the histologic grade and variant status is essential. In this study, diagnostic value of CTRW model in characterizing histological or variants was evaluated compared with ADC. The optimal performance diffusion suggested it could provide more than conventional ADC not only for pathological grading but also bladder urothelial carcinoma.
Extrahepatic tryptophan (Trp)-kynurenine (Kyn) metabolism via indoleamine 2,3-dioxygenase 1 (IDO1) induction was found to be associated with intrinsic immune regulation. However, the Trp-Kyn metabolism-associated regulation in dermatomyositis (DM) remains unknown. Therefore, we aimed investigate clinical relevance of IDO1 DM.Liquid chromatography-mass spectrometry (HPLC-MS) used examine serum Kyn and Trp concentrations DM. In addition, X-tile software determine optimal cutoff value Kyn/Trp...
摘要： 【摘要】 目的 研究合并肺间质病变或恶性肿瘤的皮肌炎/临床无肌病性皮肌炎（DM/CADM）患者的差异表达基因及相关信号通路。方法 2017年1月至2018年1月于上海交通大学医学院附属瑞金医院皮肤科确诊的DM/CADM患者27例，按照合并症状分为3组，即合并肺间质病变组10例，合并恶性肿瘤组8例，无肺间质病变和恶性肿瘤组9例。同时收集7例健康对照。采用高通量RNA测序技术筛选上述4组受试者外周血中差异表达基因，进行基因本体论（GO）分析以及京都基因与基因组百科全书（KEGG）通路富集分析。结果 与健康对照相比，DM/CADM患者4...