A5101827586- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Transportation and Mobility Innovations
- Urban Transport and Accessibility
- Transportation Planning and Optimization
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Human Mobility and Location-Based Analysis
- Embedded Systems and FPGA Design
- Genomic variations and chromosomal abnormalities
- Educational Reforms and Innovations
- Advanced Technologies in Various Fields
- Genomics and Phylogenetic Studies
- Bluetooth and Wireless Communication Technologies
- Advanced Computational Techniques in Science and Engineering
- Ultra-Wideband Communications Technology
- Thermal and Kinetic Analysis
- Genomics and Chromatin Dynamics
- Microbial Community Ecology and Physiology
- Flame retardant materials and properties
Jiangsu University
2022-2025
Xuzhou Medical College
2024-2025
Sun Yat-sen University
2020-2024
Nanjing Drum Tower Hospital
2024
Sun Yat-sen Memorial Hospital
2024
Nanjing Medical University
2024
Third Affiliated Hospital of Sun Yat-sen University
2020-2023
Shenzhen University
2022-2023
State Key Laboratory of Respiratory Disease
2022-2023
Guangzhou University of Chinese Medicine
2023
Abstract Recently, extracellular vesicles (EVs) have been emphasized in regulating the hypoxic tumor microenvironment of breast cancer (BC), where tumor‐associated fibroblasts (TAFs) play a significant role. In this study, we describe possible molecular mechanisms behind pro‐tumoral effects EVs, secreted by hypoxia (HP)‐induced TAFs, on BC cell growth, metastasis, and chemoresistance. These are based long noncoding RNA H19 (H19) identified microarray analysis. We employed an silico approach...
Abstract MALAT1-associated small cytoplasmic RNA (mascRNA) is a tRNA-like derived from nucleus-located long noncoding (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1). While MALAT1 was extensively studied and found to function in multiple cellular processes, including tumorigenesis tumor progression, the role of mascRNA largely unknown. Here we show that upregulated cancer cell lines hepatocellular carcinoma (HCC) clinical samples. Using HCC cells as model, its parent...
Abstract Hepatocellular carcinoma (HCC) is an aggressive and fatal disease caused by a subset of cancer stem cells (CSCs). It estimated that there are approximately 100 000 long noncoding RNAs (lncRNAs) in humans. However, the mechanisms which lncRNAs affect tumor stemness remain poorly understood. In present study, it found DIO3OS conserved lncRNA generally downregulated multiple cancers, including HCC, its low expression correlates with poor clinical outcomes HCC. vitro cell lines vivo...
Background and Aims: Pseudouridine is a prevalent RNA modification highly present in the serum urine of patients with HCC. However, role pseudouridylation its modifiers HCC remains unknown. We investigated function underlying mechanism pseudouridine synthase 1 (PUS1) Approach Results: By analyzing TCGA data set, PUS1 was found to be significantly upregulated human specimens positively correlated tumor grade poor prognosis Knockdown inhibited cell proliferation growth tumors subcutaneous...
Abstract Background RNA binding proteins (RBPs)—regulated gene expression play a vital role in various pathological processes, including the progression of cancer. However, RBP hepatocellular carcinoma (HCC) remains much unknown. In this study, we aimed to explore contribution CCDC137 HCC development. Methods We analyzed altered level and clinical significance database specimens. vitro cell assays vivo spontaneous mouse models were used assess function CCDC137. Finally, molecular mechanisms...
RNA-binding proteins (RBPs) play key roles in a wide range of physiological and pathological processes. To facilitate the investigation RBP functions disease associations, we updated EuRBPDB renamed it as RBPWorld (http://research.gzsys.org.cn/rbpworld/#/home). Leveraging 998 domains (RBDs) 87 Proteome (RBPome) datasets, successfully identified 1 393 413 RBPs from 445 species, including 3030 human (hRBPs). includes primary RNA targets diverse hRBPs, well potential downstream regulatory...
Breast cancer (BRCA) is among the most prevalent malignancies in women, characterized by a complex tumor microenvironment significantly influenced cancer-associated fibroblasts (CAFs). CAFs contribute to progression secreting exosomes that can modulate cell behavior. This study highlights how CAF-derived transmit long non-coding RNA (lncRNA) LINC01711, which activates TXN through miR-4510/NELFE axis, thereby enhancing glycolysis BRCA cells. Utilizing single-cell sequencing data from GEO...
N6-methyladenosine (m6A) RNA methylation has emerged as an important factor in various biological processes by regulating gene expression. However, the dynamic profile, function and underlying molecular mechanism of m6A modification during skeletal myogenesis remain elusive. Here, we report that members core methyltransferase complex, METTL3 METTL14, are downregulated muscle development. Overexpression either or METTL14 dramatically blocks myotubes formation. Correspondingly, knockdown...
Chemoresistance poses a great hindrance in the treatment of breast cancer (BC). Interestingly, exosome (Exo)-mediated transfer long noncoding RNAs (lncRNAs) has been reported to regulate chemoresistance diverse diseases. We herein investigate potential role lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) transferred by BC cell-derived Exo cells. BC-related lncRNAs were identified. Exosomes isolated and verified from The expression patterns MALAT1 then examined...
The dysfunction of regulatory T cell (Treg) is associated with the pathogenesis many immune diseases. regiments used to re-establish Treg's function are currently unsatisfactory and need be improved. purpose this study elucidate synergistic effects cortisol endoplasmic reticulum (ER) stress on impairing functions. In study, blood samples were collected from patients food allergy (FA). Immune cells purified specimens by flow cytometry. A mouse model FA was established ovalbumin as a specific...
Proper development of mammalian skeletal muscle relies on precise gene expression regulation. Our previous studies revealed that is regulated by both mRNA and long non-coding RNAs (lncRNAs). Accumulating evidence has demonstrated N 6 -methyladenosine (m A) plays important roles in various biological processes, making it essential to profile m A modification a transcriptome-wide scale developing muscle. Patterns methylation lncRNAs have not been uncovered. Here, we reveal differentially...
Potential anti-tumor effects of microRNA-497 (miR-497) have been highlighted in various malignancies including breast cancer. However, little is known about the function miR-497 and its putative target mucin1 (MUC1) The present study explored how regulates cancer progression a MUC1-dependent manner.Expression MUC1 was determined tissues cells. Methylation specific polymerase chain reaction used to measure methylation status CpG islands promoter, while chromatin immunoprecipitation assay...
Long non-coding RNAs (lncRNAs) regulate a series of physiological processes and play an important role in development, metabolism disease. Our previous studies showed that lncRNAs involved skeletal muscle differentiation. Here, we demonstrated lncRNA Has2os is highly expressed significantly elevated during cell The knockdown inhibited myocyte fusion impeded the expression myogenic factors MyHC Mef2C. Mechanically, regulates differentiation by inhibiting JNK/MAPK signaling pathway....
Electric scooters are becoming immensely popular across the world as a means of reliable transportation around many cities. As these e-scooters rely on batteries, it is important to understand how have enough battery life transport riders and when might require replacement. To this end, we develop first stochastic model capture dynamics large scooter network. In our model, assume that e-scooter batteries removable replaced by agents called swappers. Thus, gain some insight about scale...
As more people move back into densely populated cities, bike sharing is emerging as an important mode of urban mobility. In a typical system, riders arrive at station and take if it available. After retrieving bike, they ride for while, then return to near their final destinations. Since space limited in each has finite capacity docks, which cannot hold bikes than its capacity. this paper, we study systems with stations having By appropriate scaling our stochastic model, prove central limit...
As more people move back into densely populated cities, bike sharing is emerging as an important mode of urban mobility. In a typical bike-sharing system (BSS), riders arrive at station and take if it available. After retrieving bike, they ride for while, then return to near their final destinations. Since space limited in each has finite capacity docks, which cannot hold bikes than its capacity. this paper, we study BSSs with stations having By appropriate scaling our stochastic model,...