A5100692858- Chromosomal and Genetic Variations
- Cancer-related molecular mechanisms research
- Plant Molecular Biology Research
- Global Cancer Incidence and Screening
- Plant Gene Expression Analysis
- Circular RNAs in diseases
- Photosynthetic Processes and Mechanisms
- Plant tissue culture and regeneration
- Plant biochemistry and biosynthesis
- Genomics and Phylogenetic Studies
- MicroRNA in disease regulation
- Nutritional Studies and Diet
- Genomic variations and chromosomal abnormalities
- Single-cell and spatial transcriptomics
- Microbial Metabolites in Food Biotechnology
- Gut microbiota and health
- Traditional Chinese Medicine Studies
- Ethics in Clinical Research
- Cancer Risks and Factors
- Plant Virus Research Studies
- Pediatric health and respiratory diseases
- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Cell Image Analysis Techniques
- Natural product bioactivities and synthesis
Sun Yat-sen University
2025
Wuhan Institute of Virology
2024
Wuhan University
2024
State Key Laboratory of Virology
2024
Beijing Children’s Hospital
2017-2024
Anhui Agricultural University
2021-2024
Capital Medical University
2017-2024
Third Hospital of Changsha
2024
Shanghai Center For Bioinformation Technology
2023-2024
Henan University of Science and Technology
2024
Abstract Background Statistical data on the incidence, mortality, and burden of breast cancer relevant risk factors are valuable for policy-making. We aimed to estimate deaths, disability-adjusted life years (DALYs) by country, gender, age group, social-demographic status between 1990 2017. Methods extracted from 2017 Global Burden Disease (GBD) study through in 195 countries territories. Data about number incident cases, DALYs, age-standardized rates were collected. also estimated...
<h3>Importance</h3> Thyroid cancer is the most pervasive endocrine worldwide. Studies examining association between thyroid and country, sex, age, sociodemographic index (SDI), other factors are lacking. <h3>Objective</h3> To examine burden variation trends at global, regional, national levels using data on SDI. <h3>Design, Setting, Participants</h3> In this cross-sectional study, epidemiologic were gathered Global Health Data Exchange query tool, covering persons of all ages with in 195...
Abstract Background Investigations of disease incidence, mortality, and disability-adjusted life years (DALYs) are valuable for facilitating preventive measures health resource planning. We examined the tracheal, bronchus, lung (TBL) cancer burdens worldwide according to sex, age, social development index (SDI) at global, regional, national levels. Methods assessed TBL burden using data from Global Burden Disease (GBD) database, including 21 regions, 195 countries, territories in diagnostic...
A high-quality genome is the basis for studies on functional, evolutionary, and comparative genomics. The majority of attention has been paid to solution complex chromosome structures highly repetitive sequences, along with emergence a new 'telomere-to-telomere (T2T) assembly' era. However, bioinformatic tools automatic construction and/or characterization T2T are limited. Here, we developed user-friendly web toolkit, quarTeT, which currently includes four modules: AssemblyMapper, GapFiller,...
Abstract Background The epidemiology of esophageal cancer (EC) can elucidate its causes and risk factors help develop prevention strategies. We aimed to provide an overview the burden, trends, EC in China from 1990 2017. also investigated differences between China, Japan, South Korea discussed possible disparities. Methods used Global Burden Disease Study 2017 obtain data on incident cases, deaths, disability-adjusted life-year (DALY) age-standardized incidence rate (ASIR), death (ASDR),...
Larynx cancer is one of the most common cancers in head and neck. This study aimed to investigate health burden larynx at global, regional, national levels. We collected data between 1990 2017 from Global Burden Disease study, including incidence, mortality, disability adjusted life-years (DALYs). Estimated annual percentage changes (EAPCs) were calculated assess age-standardized rate (ASR) cancer. From 2017, LC incident cases increased by 58.67%; however, incidence (ASIR) decreased, with an...
Background The patterns of the incidence and mortality prostate cancer (PC) have been changing over years. In addition, unclear etiology PC necessitates further studies into geographic distribution age composition patients with PC. This study was aimed at examining epidemiology to help policymakers allocate limited resources health care system accordingly. Methods Annual case data age‐standardized rates (ASRs) were obtained for incidence, mortality, disability‐adjusted life‐years (DALYs)...
Abstract Kiwifruit is an economically and nutritionally important fruit crop with extremely high contents of vitamin C. However, the previously released versions kiwifruit genomes all have a mass unanchored or missing regions. Here, we report highly continuous completely gap-free reference genome Actinidia chinensis cv. ‘Hongyang’, named Hongyang v4.0, which first to achieve two de novo haploid-resolved haplotypes, HY4P HY4A. HY4A total length 606.1 599.6 Mb, respectively, almost entire...
<h3>Importance</h3> It is difficult for policy makers and clinicians to formulate targeted management strategies mesothelioma because data on current epidemiological patterns worldwide are lacking. <h3>Objective</h3> To evaluate the burden across world describe its distribution over time by sociodemographic index (SDI) level, geographic location, sex, age. <h3>Design, Setting, Participants</h3> Annual case age-standardized rates of incidence, death, disability-adjusted life-years associated...
Introduction This study aimed to describe the latest epidemiology of female breast cancer globally, analyze change pattern incidence rates and disease’s association with age, period, birth cohort, subsequently present a forecast incidence. Methods Data for analysis were obtained from Global Burden Disease (GBD) Study 2019 World Population Prospects revision by United Nations (UN). We described age-standardized (ASIRs) 1990 then calculated relative risks period cohort using an...
Actinidia arguta, known as hardy kiwifruit, is a widely cultivated species with distinct botanical characteristics such small and smooth-fruited, rich in beneficial nutrients, rapid softening tolerant to extremely low temperatures. It contains the most diverse ploidy types, including diploid, tetraploid, hexaploid, octoploid, decaploid. Here we report haplotype-resolved tetraploid genome (A. arguta cv. 'Longcheng No.2') containing four haplotypes, each 40,859, 41,377, 39,833 39,222...
Circular RNAs (circRNAs), a class of widespread endogenous RNAs, play crucial roles in diverse biological processes and are potential biomarkers human diseases cancers. Cerebellar-degeneration-related protein 1 antisense RNA (CDR1as), an oncogenic circRNA, is involved tumorigenesis dysregulated hepatocellular carcinoma (HCC). However, the molecular mechanisms underlying CDR1as functions HCC remain unclear. Here we explored searched for CDR1as-regulated proteins cells. A quantitative...
Background: Colorectal cancer remains a public health problem worldwide. Dietary risk factors play key role in the carcinogenesis and progression of colorectal cancer. This study aimed to explore geographical temporal trends various dietary factor-related cancers. Methods: Data were extracted from Global Burden Disease (GBD) 2019 study, including deaths, disability-adjusted life-years (DALYs), age-standardized rate (ASR), summary exposure value (SEV) among 4 world regions, 11 age groups, 21...
Sufficient light is essential for the growth and physiological functions of photosynthetic organisms, but prolonged exposure to high (HL) stress can cause cellular damage ultimately result in death these organisms. Synechococcus sp. PCC 7002 (hereafter 7002) a unicellular cyanobacterium with exceptional tolerance HL intensities. However, molecular mechanisms involved response by are not well understood. Here, an integrated RNA sequencing transcriptomic quantitative proteomic analysis was...
Abstract Cancer cells present sialylated glycoconjugates that modulate the activity of various immune within tumor microenvironment through trans interaction with immunosuppressive Siglec receptors. Identifying counter receptors for Siglecs can provide valuable targets cancer immunotherapy, but it presents significant challenges. Here, identification DSG2 (Desmoglein 2) as a dominant receptor Siglec‐9 in melanoma is reported, using workflow combines strength proximity labeling and advantage...
Abstract Whole-body regeneration of planarians is a natural wonder but how it occurs remains elusive. It requires coordinated responses from each cell in the remaining tissue with spatial awareness to regenerate new cells and missing body parts. While previous studies identified genes essential regeneration, more efficient screening approach that can identify regeneration-associated context needed. Here, we present comprehensive three-dimensional spatiotemporal transcriptomic landscape...
Probiotics, known for regulating gut microbiota, may aid those with overweight or obesity, but their mechanisms require more research. This study involved 75 obese young adults, randomly assigned to either a
Multiplex ligation-dependent probe amplification (MLPA) is widely used to screen genes of interest for deletions and duplications. Since MLPA usually based on size-separation the products, maximum number target sequences that can be screened in parallel limited ∼40. We report design a robust array-based format uses products essentially uniform size (100–120 bp) distinguishes between them by virtue incorporated tag sequences. were thus able increase complexity 124, with very product yields...
Abstract Triterpenoid Toosendanin (TSN) exhibits a plenty of pharmacological effects in human and great values agriculture. However, the hepatotoxicity caused by TSN or Melia-family plants containing used traditional Chinese medicine has been reported mechanisms TSN-induced liver injury (TILI) still remain largely unknown. In this study, dose- time-dependent on mice were investigated an integrated microRNA-mRNA approach as well general toxicological assessments. As results, alterations...