A5115592147- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Global Cancer Incidence and Screening
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Cancer Risks and Factors
- Hormonal Regulation and Hypertension
- Chemokine receptors and signaling
- Multiple and Secondary Primary Cancers
- Acute Lymphoblastic Leukemia research
- Advanced Breast Cancer Therapies
- Bioinformatics and Genomic Networks
- Reproductive System and Pregnancy
- Photodynamic Therapy Research Studies
- Genetic factors in colorectal cancer
- Adrenal and Paraganglionic Tumors
- Renin-Angiotensin System Studies
- Agricultural Systems and Practices
- Gene expression and cancer classification
- Vitamin D Research Studies
- Immune cells in cancer
- Head and Neck Cancer Studies
- Ubiquitin and proteasome pathways
- Lymphoma Diagnosis and Treatment
Peking University
2020-2024
Peking University Sixth Hospital
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2019-2022
Zhejiang University
2020-2021
Beijing Anzhen Hospital
2021
Capital Medical University
2020-2021
Beijing Obstetrics and Gynecology Hospital
2020
Capital University
2020
Jilin University
2020
Peking University First Hospital
2020
Chronic kidney disease (CKD) is a public health problem largely caused by diabetes. The epidemiology of diabetes mellitus-related CKD (CKD-DM) could provide specific support to lessen global, regional, and national burden.Data were derived from the GBD 2019 study, including four measures age-standardized rates (ASRs). Estimated annual percentage changes 95% CIs calculated evaluate variation trend ASRs.Diabetes majority new cases patients with in all regions. All ASRs for type 2...
Abstract Background Investigations of disease incidence, mortality, and disability-adjusted life years (DALYs) are valuable for facilitating preventive measures health resource planning. We examined the tracheal, bronchus, lung (TBL) cancer burdens worldwide according to sex, age, social development index (SDI) at global, regional, national levels. Methods assessed TBL burden using data from Global Burden Disease (GBD) database, including 21 regions, 195 countries, territories in diagnostic...
Cervical cancer (CC) is a leading cause of cancer-related death in women. Limited studies have investigated whether immune-related genes (IRGs) or tumor immune microenvironment (TIME) could be indicators for CC prognoses. The aim this study was to develop an improved prognostic signature based on IRGs TIME predict survival and response checkpoint inhibitors (ICIs). A constructed using bioinformatics method its predictive capability validated. mechanisms underlying the signature's were...
Larynx cancer is one of the most common cancers in head and neck. This study aimed to investigate health burden larynx at global, regional, national levels. We collected data between 1990 2017 from Global Burden Disease study, including incidence, mortality, disability adjusted life-years (DALYs). Estimated annual percentage changes (EAPCs) were calculated assess age-standardized rate (ASR) cancer. From 2017, LC incident cases increased by 58.67%; however, incidence (ASIR) decreased, with an...
Cancer is the leading cause of death among children.We report on latest estimates burden cancer children at global, regional, and national levels from 1990 to 2019.Based Global Burden Disease Study 2019, children's data were analyzed by sex, age, year, location. Age-standardized rates used compare burdens regions nations. Joinpoint analysis was applied assess temporal trend global childhood burden.In 291,319 (95% uncertainty interval [UI], 254,239 331,993) new cases 98,834 (86,124 113,581)...
Abstract. Both long-term observation data and model simulations suggest an increasing chance of serious drought in the dry season extreme flood wet southern China, yet little is known about how changes precipitation pattern will affect soil respiration region. We conducted a field experiment to study responses manipulations – exclusion mimic drought, double simulate flood, ambient as control (abbr. EP, DP AP, respectively) three subtropical forests China. The forest sites include Masson pine...
Immune checkpoint inhibitors (ICIs) have been successfully used for treating melanoma and non-small cell lung cancer. However, many patients with breast cancer (BC) show low response to ICIs due the paucity of infiltrating immune cells. Pseudogenes, as a particular kind long-chain non-coding RNA, play vital roles in tumorigenesis, but their potential tumor immunology remain unclear. In this study that data from online databases, novel pseudogene HLA-DPB2 its parental gene HLA-DPB1 were...
Sonodynamic Therapy (SDT) has good targeting and non-invasive advantages in solid cancers, but its antitumor effect is not sufficient to replace traditional treatments. Some studies that combined SDT with chemotherapy or nanoparticles have managed enhance efficiency overcome the side effects of chemotherapy.In this study, we synthesized characterized mesoporous silica (MSN-DOX-Ce6) loaded doxorubicin (DOX) sonosensitizer, chlorin e6 (Ce6). Then, conducted vitro vivo experiments explore...
Background: Exposure to ambient particulate matter pollution (APMP) is a global health issue that directly affects the human respiratory system. Thus, we estimated spatiotemporal trends in burden of APMP-related diseases from 1990 2019. Methods: Based on Global Burden Disease Study 2019, data were analyzed by age, sex, cause, and location. Joinpoint regression analysis was used analyze temporal different over 30 years. Results: Globally, APMP contributed most chronic obstructive pulmonary...
To identify a glycolysis-related gene signature for the evaluation of prognosis in patients with breast cancer, we analyzed data training set from TCGA database and four validation cohorts GEO ICGC databases which included 1,632 cancer. We conducted GSEA, univariate Cox regression, LASSO, multiple regression analysis. Finally, an 11 - related to glycolysis predicting survival cancer was developed. And Kaplan–Meier analysis ROC analyses suggested that showed good prognostic ability BC TCGA,...
Glioma is the most common tumor of central nervous system; variation in susceptibility and prognosis worldwide suggests that there are molecular genetic differences among individuals. The H19 gene plays a dual role carcinogenesis. In this study, associations between polymorphisms as well glioma were evaluated. total, 605 patients with 1,300 cancer-free subjects enrolled study. Individuals rs3741219 A>G allele less likely to develop (relative risk [RR] = 0.54, 95% confidence interval [95% CI]...
Adjuvant chemotherapy remains the only recommended treatment for patients with triple-negative breast cancer (TNBC). However, existing evidence is not enough to recommend adjuvant therapies T1 N0 M0 TNBC.To evaluate association of different survival outcome in TNBC stratified by stage and age.Postoperative diagnosed as having between 2010 2015 who were enrolled Surveillance, Epidemiology, End Results registry program included this population-based cohort study. Data analysis was performed...
<h3>Importance</h3> Breast cancer (BC), a common malignant tumor, ranks first among cancers in terms of morbidity and mortality female patients. Currently, identifying effective prognostic models has significant association with the prediction overall survival patients BC guidance clinicians early diagnosis treatment. <h3>Objectives</h3> To identify potential DNA repair–related signature through comprehensive evaluation to further improve accuracy BC. <h3>Design, Setting, Participants</h3>...
Abstract Colorectal cancer (CRC) is the third most common malignant tumor. DNA damage plays a crucial role in tumorigenesis, and abnormal repair pathways affect occurrence progression of CRC. In current study, we aimed to construct repair-related gene (DRG) signature predict overall survival (OS) patients with CRC patients. The differentially expressed DRGs (DE-DRGs) were analyzed using Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. prognostic was identified by...
The association between vitamin C intake and breast cancer is unclear. This meta-analysis aimed to precisely assess the of with risk mortality. We searched PubMed, Embase, Web Science databases up June 2020 found 69 studies relevant (54 studies) survival (15 studies). Relative risks 95% confidence intervals were calculated using random-effects models. Pooled results suggested that highest versus lowest was significantly associated a lower incidence (Relative Risk = 0.86; interval,...
Background: Accumulating evidence demonstrates that perivascular adipose tissue (PVAT) plays an important role in maintaining vascular homeostasis. The formation of macrophage foam cells is a central feature atherosclerosis. This study aimed to evaluate the effect PVAT-derived exosomes (EXOs) on lipid accumulation macrophages and verify anti-atherogenic characteristics PVAT. Methods Results: We extracted EXOs from PVAT subcutaneous (SCAT) wild-type C57BL/6J mice. After coincubation, were...
Background Observational studies have shown a controversial relationship between dietary fat intake and Alzheimer's disease, the causal effects are unclear. Aims To assess of total fat, saturated polyunsaturated (PUF) intakes on risk disease. Method A two-sample Mendelian randomisation analysis was performed using genome-wide association study summary statistics different types from UK Biobank ( n = 51 413) late-onset disease (LOAD; 4282 cases, 307 112) all forms (6281 309 154) FinnGen...
Abstract Background Previous studies suggested that CXCL12 was involved in the development, metastasis, and invasion of breast cancer, genetic variants were associated with diagnosis prognosis patients cancer. The present study aimed to assess relationships between polymorphisms (rs1801157, rs2297630, rs2839693) susceptibility clinicopathological features Methods A case-control conducted 434 cancer 450 health controls. Student t -test chi-square test used analyze differences age distribution...