A5101425427- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Chronic Myeloid Leukemia Treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- DNA Repair Mechanisms
- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Cancer Risks and Factors
- Multiple and Secondary Primary Cancers
- Global Cancer Incidence and Screening
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Liver physiology and pathology
- Single-cell and spatial transcriptomics
- Immunotherapy and Immune Responses
- Food Quality and Safety Studies
- Garlic and Onion Studies
- Insect-Plant Interactions and Control
- Hepatocellular Carcinoma Treatment and Prognosis
- GABA and Rice Research
- Gout, Hyperuricemia, Uric Acid
- Traditional Chinese Medicine Studies
- Protein Degradation and Inhibitors
Soochow University
2024-2025
First Affiliated Hospital of Henan University
2025
First Affiliated Hospital of Zhengzhou University
2022-2025
State Key Laboratory of Genetic Engineering
2025
Fudan University
2025
St. Jude Children's Research Hospital
2019-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2021-2024
Shenyang Pharmaceutical University
2023-2024
Guangzhou University of Chinese Medicine
2022-2023
Beihang University
2023
Introduction This study aimed to describe the latest epidemiology of female breast cancer globally, analyze change pattern incidence rates and disease’s association with age, period, birth cohort, subsequently present a forecast incidence. Methods Data for analysis were obtained from Global Burden Disease (GBD) Study 2019 World Population Prospects revision by United Nations (UN). We described age-standardized (ASIRs) 1990 then calculated relative risks period cohort using an...
Leukemia can arise at various stages of the hematopoietic differentiation hierarchy, but impact developmental arrest on drug sensitivity is unclear. Applying network-based analyses to single-cell transcriptomes human B cells, we define genome-wide signaling circuitry for each cell stage. Using this reference, comprehensively map states acute lymphoblastic leukemia (B-ALL), revealing its strong correlation with asparaginase, a commonly used chemotherapeutic agent. Single-cell multi-omics...
The process of searching for and selecting clinical evidence systematic reviews (SRs) or guidelines is essential researchers in Traditional Chinese medicine (TCM). However, this often time-consuming resource-intensive. In study, we introduce a novel precision-preferred comprehensive information extraction selection procedure to enhance both the efficiency accuracy TCM practitioners. We integrated an established deep learning model (Evi-BERT combined rule-based method) with Boolean logic...
Long noncoding RNA HOX antisense intergenic myeloid 1 (HOTAIRM1) has been characterized as a critical factor in all-trans retinoic acid (ATRA)-induced differentiation of acute promyelocytic leukemia (APL) cells. However, the essential transcription for gene expression HOTAIRM1 is still unknown. Chromatin immunoprecipitation (ChIP) assays revealed that PU.1 constitutively bound to regulatory region HOTAIRM1. Co-expression led transactivation reporter assay. Detailed analysis showed two...
Acute lymphoblastic leukemia (ALL) is the most common cancer in children and can arise B or T lymphoid lineages. Although risk loci have been identified for B-ALL, inherited basis of T-ALL mostly unknown, with a particular paucity genome-wide investigation susceptibility variants large patient cohorts.
Background: Exposure to ambient particulate matter pollution (APMP) is a global health issue that directly affects the human respiratory system. Thus, we estimated spatiotemporal trends in burden of APMP-related diseases from 1990 2019. Methods: Based on Global Burden Disease Study 2019, data were analyzed by age, sex, cause, and location. Joinpoint regression analysis was used analyze temporal different over 30 years. Results: Globally, APMP contributed most chronic obstructive pulmonary...
CRISPR/Cas9-mediated genome editing has the potential to delete PD-L1 both on cell surface and inside cell, thereby inhibiting tumor growth migration overcoming immunosuppression. ZG16, with its lectin structure, can reduce expression surface. However, direct comparison of two approaches in Pancreatic ductal adenocarcinoma (PDAC) cells not yet been investigated. In this study, we established Panc-1 line: one knockout another ZG16 overexpression. Both methods promoted polarization...
Summary Improving plant architecture and increasing yields are the main goals of rice breeders. However, yield is a complex trait influenced by many yield‐related traits. Identifying characterizing important genes in coordinated network regulating traits their interactions conducive to cultivating high‐yielding varieties. In this study, we determined that interaction between mitogen‐activated protein kinase kinase5 (OsMAPKKK5) brassinosteroid‐signalling kinase1–1 (OsBSK1–1) regulates rice....
Genetic alterations in the RUNX1 gene are associated with benign and malignant blood disorders, particularly of megakaryocyte myeloid lineages. The role acute lymphoblastic leukemia (ALL) is less clear, how germline genetic variation influences predisposition to this type leukemia. Sequencing 4,836 children B-ALL 1,354 cases T-ALL, we identified 31 18 variants, respectively. variants consistently showed minimal damaging effects. By contrast, 6 T-ALL-related result drastic loss activity as a...
Blinatumomab is an efficacious immunotherapeutic agent in B cell acute lymphoblastic leukemia (B-ALL). However, the pharmacogenomic basis of response to blinatumomab unclear. Using genome-wide CRISPR, we comprehensively identified intrinsic factors sensitivity, i.e., loss
Clerodendranthus spicatus Thunb. (Labiatae) (CS), a perennial traditional Chinese medicinal herb that can reduce serum uric acid (sUA) levels and ameliorate renal function is widely used to treat hyperuricaemic nephropathy (HN).To investigate the molecular mechanism of action CS in HN treatment using vivo vitro experiments.Sprague-Dawley rats were randomly divided into control, HN, positive control allopurinol groups. The group was intraperitoneally injected with 750 mg/kg oxonic potassium...
Abstract Phosphorylation proteomics is the basis for study of abnormally activated kinase signaling pathways in breast cancer, which facilitates discovery new oncogenic agents and drives potential targets early diagnosis therapy cancer. In this study, we have explored aberrantly active kinases cancer development to elucidate role PRKCD_pY313 triple negative (TNBC) progression. We collected 47 pairs paired far-cancer normal tissues analyzed phosphorylated tyrosine (pY) peptides by Superbinder...
Searching for natural products with antitumor and immune-enhancing activities is an important aspect of cancer research.