A5012815088- Cancer, Hypoxia, and Metabolism
- ATP Synthase and ATPases Research
- Ubiquitin and proteasome pathways
- Toxic Organic Pollutants Impact
- Climate Change and Health Impacts
- Plant and Fungal Interactions Research
- Mitochondrial Function and Pathology
- Air Quality and Health Impacts
- Genetic Mapping and Diversity in Plants and Animals
- RNA modifications and cancer
- Energy and Environment Impacts
- Immunotherapy and Immune Responses
- Effects and risks of endocrine disrupting chemicals
- Tea Polyphenols and Effects
- Genetic diversity and population structure
- Advanced battery technologies research
- PARP inhibition in cancer therapy
- Tuberous Sclerosis Complex Research
- Food Chemistry and Fat Analysis
- Cerebrovascular and genetic disorders
- Environmental Quality and Pollution
- Plant Gene Expression Analysis
- Histone Deacetylase Inhibitors Research
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
South China Normal University
2023-2025
Xiangya Hospital Central South University
2025
Third Xiangya Hospital
2025
Zhejiang University
2021-2024
Huazhong University of Science and Technology
2024
Tongji Hospital
2023-2024
Hebei University of Technology
2024
Guizhou University
2022-2024
Hangzhou Medical College
2024
Zhejiang Provincial People's Hospital
2024
Chronic kidney disease (CKD) is a public health problem largely caused by diabetes. The epidemiology of diabetes mellitus-related CKD (CKD-DM) could provide specific support to lessen global, regional, and national burden.Data were derived from the GBD 2019 study, including four measures age-standardized rates (ASRs). Estimated annual percentage changes 95% CIs calculated evaluate variation trend ASRs.Diabetes majority new cases patients with in all regions. All ASRs for type 2...
Flow channels with baffles can enhance the transport of reactants and improve performance proton exchange membrane fuel cell (PEMFC). In this study, five different structures flow are proposed, mass transfer PEMFC baffled compared by CFD method. The results show that a cutting cylindrical baffle has best an output current density 1.82 A/m2 when voltage is 0.4 V. Baffle design promote reaction gas transmission while also increasing concentration in channel. Due to circular arc surface...
Introduction This study aimed to describe the latest epidemiology of female breast cancer globally, analyze change pattern incidence rates and disease’s association with age, period, birth cohort, subsequently present a forecast incidence. Methods Data for analysis were obtained from Global Burden Disease (GBD) Study 2019 World Population Prospects revision by United Nations (UN). We described age-standardized (ASIRs) 1990 then calculated relative risks period cohort using an...
RNA interference (RNAi) is a simple and rapid method for silencing genes in various organisms, it widely used gene function genetics research. RNAi has been developed as novel pest management strategy. Double-stranded RNAs (dsRNAs) delivered via microinjection, ingestion, or soaking are effective insect pests, whereas oral topical delivery methods feasible field applications. Here, we summarize delivery, of dsRNA target genes, including those involved energy metabolism, synthesis essential...
The poor prognosis and high mortality of patients with ovarian cancer result in part from their response to platinum-based chemotherapy. However, the precise mechanism behind cisplatin resistance is still not fully understood. In present study, authors explored perspective glucose metabolism human cancer. experiments using genetically matched cell lines SKOV3 (cisplatin-sensitive) SKOV3/DDP (cisplatin-resistant) study provided some important findings. First, comparison cells, cells exhibited...
Studying the genetic characteristics of tea plant (Camellia spp.) leaf traits is essential for improving yield and quality through breeding selection. Guizhou Plateau, an important part original center plants, has rich resources. However, few studies have explored associations between single nucleotide polymorphism (SNP) markers in Guizhou.
Drug resistance remains a barrier in the clinical treatment of ovarian cancer. Proteasomal and antioxidant activities play important roles tumor drug resistance, increasing evidence suggests existence an interaction between proteasomal activities. However, mechanism synergistic effects activity antioxidation on is not completely clear. In this study, we compared two cancer cells, A2780 SKOV3 cells. Among them, cell human clear carcinoma line that resistant to platinum. We found with findings...
Background: Exposure to ambient particulate matter pollution (APMP) is a global health issue that directly affects the human respiratory system. Thus, we estimated spatiotemporal trends in burden of APMP-related diseases from 1990 2019. Methods: Based on Global Burden Disease Study 2019, data were analyzed by age, sex, cause, and location. Joinpoint regression analysis was used analyze temporal different over 30 years. Results: Globally, APMP contributed most chronic obstructive pulmonary...
Plants typically exhibit the purple phenomenon as a result of an increase in flavonoids and anthocyanins. A new tea germplasm 'P113' was recently selected from <italic>Camellia tachangensis</italic>, which is tender shoots. In present study, integrated transcriptome metabolome were used to analyze flavonoid metabolite components genes involved biosynthesis 'P113'. total 86 metabolites identified, including 70 significantly differential (<italic>p</italic> < 0.05) they enriched three...
Abstract Background Guizhou Plateau, as one of the original centers tea plant, has a profound multi-ethnic cultural heritage and abundant germplasm resources. However, impact indigenous community factors on genetic diversity, population structure geographical distribution plant is still unclear. Results Using genotyping-by-sequencing (GBS) approach, we collected 415 accessions from study sites, estimated developed core collection, conducted genome-wide association (GWAS) based 99,363...
Abstract BACKGROUND Insects rely on their effective innate immune system to defend against pathogen infection, and pattern recognition receptors (PRRs) play a crucial role in insect immunity. Galectins, family of animal β‐galactoside‐binding lectins, may serve as PRRs. Mammalian galectins are involved diverse physiological processes; however, less is known about functions galectins. RESULT In this study, we focused an agricultural pest Spodoptera litura identified total 13 Slgalectins ,...
Background Epidemiological trends of type 2 diabetes mellitus attributable to fine particulate matter (PM 2.5 ) pollution remain unclear. Here, we estimated spatiotemporal burden PM pollution, including ambient (APMP) and household air (HAP), from 1990–2019. Methods Data were obtained the Global Burden Disease Study 2019 analyzed by age, sex, year, location. Joinpoint regression analysis was applied in temporal over 30 years. Results Globally, contributed 292.5 thousand deaths 13 million...
Abstract Background New strategies are needed to improve the treatment of patients with breast cancer (BC). Oncolytic virotherapy is a promising new tool for but still has limited overall durable antitumor response. A novel replicable recombinant oncolytic herpes simplex virus type 1 called VG161 been developed and demonstrated effects in several cancers. Here, we explored efficacy immune response cotreatment paclitaxel (PTX) which as viral immunotherapy BC. Methods The effect PTX was...
Ovarian cancer is a gynecological malignancy with high mortality. Adjuvant therapy such as chemoradiotherapy inevitably leads to side effects and drug resistance. In recent years, traditional Chinese medicine has been widely studied for its safety, effectiveness, unique pharmacological effects. Polyphyllin VII an important component of Rhizoma paridis saponins, cytotoxic on many types cells. The aim the present study was evaluate anti‑tumor activity polyphyllin in human ovarian Recent...
Pyruvate dehydrogenase kinase 1 (PDK1) is a key factor in the connection between glycolysis and tricarboxylic acid cycle. Restoring mitochondrial OXPHOS function by inhibiting through targeting PDK1 has become hot spot for tumor therapy. However, specific mechanism which metabolic changes affect remains unclear. Recent studies have found that quality control such as protein homeostasis plays an important role maintaining function. Here, we focused on explored We showed glucose metabolism...