A5101880427- RNA modifications and cancer
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Global Cancer Incidence and Screening
- Circular RNAs in diseases
- Cancer Risks and Factors
- Energy and Environment Impacts
- RNA Research and Splicing
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- RNA and protein synthesis mechanisms
- Acute Lymphoblastic Leukemia research
- Childhood Cancer Survivors' Quality of Life
- Multiple and Secondary Primary Cancers
- Glycosylation and Glycoproteins Research
- Caveolin-1 and cellular processes
- Erythrocyte Function and Pathophysiology
- Colorectal Cancer Screening and Detection
- Cancer-related gene regulation
Zhejiang University
2018-2022
First Affiliated Hospital Zhejiang University
2021
Blood Center of Zhejiang Province
2018-2019
Advanced Cancer Therapeutics
2018
Recently, increasing evidence has uncovered the roles of mRNA-miRNA-lncRNA network in multiple human cancers. However, a systematic linked to pancreatic cancer prognosis is still absent.Differentially expressed genes (DEGs) were first identified by mining GSE16515 and GSE15471 datasets. DAVID database was utilized conduct functional enrichment analysis. Protein-protein interaction (PPI) built using STRING database, hub Cytoscape plug-in CytoHubba. Upstream miRNAs lncRNAs mRNAs predicted...
Cancer is the leading cause of death among children.We report on latest estimates burden cancer children at global, regional, and national levels from 1990 to 2019.Based Global Burden Disease Study 2019, children's data were analyzed by sex, age, year, location. Age-standardized rates used compare burdens regions nations. Joinpoint analysis was applied assess temporal trend global childhood burden.In 291,319 (95% uncertainty interval [UI], 254,239 331,993) new cases 98,834 (86,124 113,581)...
Introduction This study aimed to describe the latest epidemiology of female breast cancer globally, analyze change pattern incidence rates and disease’s association with age, period, birth cohort, subsequently present a forecast incidence. Methods Data for analysis were obtained from Global Burden Disease (GBD) Study 2019 World Population Prospects revision by United Nations (UN). We described age-standardized (ASIRs) 1990 then calculated relative risks period cohort using an...
Hepatocellular carcinoma (HCC) is one of the most lethal cancer, mainly attributing to its high tendency metastasis. Vascular invasion provides a direct path for solid tumor Mounting evidence has demonstrated that microRNAs (miRNAs) are related human cancer onset and progression including In search invasion-metastasis-associated miRNAs in HCC, microarray dataset GSE67140 was downloaded from Gene Expression Omnibus database. Differentially expressed (DE-miRNAs) were obtained by R software...
Lacking of both prognostic biomarkers and therapeutic targets, triple-negative breast cancer (TNBC) underscores pivotal needs to uncover novel viable therapies. MicroRNAs have broad biological functions in cancers may serve as ideal biomarkers. In this study, by data mining the Cancer Genome Atlas database, we screened out 4 differentially-expressed microRNAs (DEmiRNAs) between TNBC normal samples: miR-135b-5p, miR-9-3p, miR-135b-3p miR-455-5p. They were specially correlated with prognosis...
Roles of Piezo-type mechanosensitive ion channel component 2 (PIEZO2) in cancer remain largely unknown.Herein, we explored PIEZO2 expression, prognosis and underlying mechanisms cancer.Breast was selected as the candidate its relatively higher expression level than other human tissues.Next, identified a decreased breast compared with normal controls, found that positively correlated estrogen receptor (ER) progesterone (PR) status but negatively epidermal growth factor (HER2) status,...
Background: Neoadjuvant chemotherapy (NAC) is an effective therapeutic regimen for patients with breast cancer. However, some individuals cannot benefit from NAC because of drug resistance. To date, valid strategies about enhancing sensitivity cancer to are still scarce. miRNAs have been reported proverbially be involved in the onset and development malignancies including Methods: GSE73736 was downloaded GEO database. Student’s t-test conducted acquire differentially expressed-miRNAs...
Pseudogenes play pivotal roles in tumorigenesis. Previous studies have suggested that pituitary tumor-transforming 3, pseudogene (PTTG3P), serves as an oncogene human cancers. However, its expression pattern, biological function, and underlying mechanism breast cancer remain unknown. In this study, we demonstrated elevated of PTTG3P discovered correlated negatively with estrogen receptor (ER) progesterone (PR) status, but linked positively to basal-like triple-negative Nottingham prognostic...
Background: Glioblastoma multiforme (GBM), the most common and aggressive human malignant brain tumor, is notorious for its limited treatment options poor prognosis. MicroRNAs (miRNAs) are found to be involved in tumorigenesis of GBM. However, a comprehensive miRNA-mRNA regulatory network has still not been established. Methods: A miRNA microarray dataset (GSE90603) was obtained from GEO database. Then, we employed GEO2R tool perform differential expression analysis. Potential transcription...
Background: Exposure to ambient particulate matter pollution (APMP) is a global health issue that directly affects the human respiratory system. Thus, we estimated spatiotemporal trends in burden of APMP-related diseases from 1990 2019. Methods: Based on Global Burden Disease Study 2019, data were analyzed by age, sex, cause, and location. Joinpoint regression analysis was used analyze temporal different over 30 years. Results: Globally, APMP contributed most chronic obstructive pulmonary...
Background Epidemiological trends of type 2 diabetes mellitus attributable to fine particulate matter (PM 2.5 ) pollution remain unclear. Here, we estimated spatiotemporal burden PM pollution, including ambient (APMP) and household air (HAP), from 1990–2019. Methods Data were obtained the Global Burden Disease Study 2019 analyzed by age, sex, year, location. Joinpoint regression analysis was applied in temporal over 30 years. Results Globally, contributed 292.5 thousand deaths 13 million...
Mounting evidences have demonstrated that HCC patients with or without cirrhosis possess different clinical characteristics, tumor development and prognosis. However, few studies directly investigated the underlying molecular mechanisms between non-cirrhotic cirrhotic HCC.The information RNA-seq data were downloaded from The Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) of obtained by R software. Functional annotation pathway enrichment analysis performed...
Recent studies have well demonstrated that 5-methylcytosine (m5C) regulators play pivotal roles in pathological conditions, including cancer. This study first tried to identify potential breast cancer by combination of expression, diagnosis, and survival analyses, then established an ncRNA-mRNA network accounting for m5C regulators' Among 13 regulators, DNMT3B ALYREF were significantly upregulated their high expression indicated unfavorable prognosis. Both possessed the statistical abilities...
Abstract: Background Growing evidences have showed that mucins (MUCs) are linked to occurrence and progression of human cancers. However, a comprehensive study regarding the expression, diagnosis, prognosis mechanism MUCs in breast cancer remains absent. Methods: A series silico analyses were employed this study. Results: After performing analysis for MUCs, MUC14 was identified as most potential regulator cancer, with downregulated expression both mRNA protein levels significant diagnostic...
Abstract Background This study aimed to describe the latest epidemiology of female breast cancer globally, analyze change pattern incidence rates and disease’s association with age, period, birth cohort, subsequently present a forecast incidence. Methods Data for analysis were obtained from Global Burden Disease (GBD) Study 2019 World Population Prospects revision by United Nations (UN). We described age-standardized (ASIRs) 1990 then calculated relative risks period cohort using an...