A5026909961- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- RNA modifications and cancer
- Mechanisms of cancer metastasis
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
- Erythrocyte Function and Pathophysiology
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Ubiquitin and proteasome pathways
- Lung Cancer Research Studies
- Cancer-related gene regulation
- Caveolin-1 and cellular processes
- Helicobacter pylori-related gastroenterology studies
- Axon Guidance and Neuronal Signaling
- ATP Synthase and ATPases Research
- Advanced Breast Cancer Therapies
- Cancer therapeutics and mechanisms
- Digestive system and related health
- Genetic factors in colorectal cancer
- IL-33, ST2, and ILC Pathways
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pancreatic and Hepatic Oncology Research
- Neutropenia and Cancer Infections
Jiaxing University
2018-2024
First Hospital of Jiaxing
2018-2024
Peking University
2024
Sichuan University
2024
Peking University Third Hospital
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Fu Wai Hospital
2024
State Key Laboratory of Cardiovascular Disease
2024
ShanghaiTech University
2022
Shanghai Institute of Materia Medica
2017-2021
Hepatocellular carcinoma (HCC) is one of the most lethal cancer, mainly attributing to its high tendency metastasis. Vascular invasion provides a direct path for solid tumor Mounting evidence has demonstrated that microRNAs (miRNAs) are related human cancer onset and progression including In search invasion-metastasis-associated miRNAs in HCC, microarray dataset GSE67140 was downloaded from Gene Expression Omnibus database. Differentially expressed (DE-miRNAs) were obtained by R software...
Roles of Piezo-type mechanosensitive ion channel component 2 (PIEZO2) in cancer remain largely unknown.Herein, we explored PIEZO2 expression, prognosis and underlying mechanisms cancer.Breast was selected as the candidate its relatively higher expression level than other human tissues.Next, identified a decreased breast compared with normal controls, found that positively correlated estrogen receptor (ER) progesterone (PR) status but negatively epidermal growth factor (HER2) status,...
Hepatocellular carcinoma (HCC) is notorious for its poor prognosis. Increasing evidence has demonstrated that semaphorin 3F (SEMA3F) plays key roles in initiation and progression of several types human cancer. However, the specific role mechanism SEMA3F HCC remains not fully determined. In this study, we first performed pan-cancer analysis SEMA3F's expression prognosis using The Cancer Genome Atlas (TCGA) Genotype-Tissue Expression (GTEx) data found might be a potential oncogene HCC....
IL-17 is a proinflammatory cytokine produced by activated Th17 cells and other immune cells. IL-17-producing are major contributors to chronic inflammatory autoimmune diseases, such as multiple sclerosis, rheumatoid arthritis, bowel disease. Although the transcriptional regulation of well understood, posttranscriptional gene expression remains unknown. The RNA-binding protein HuR positively regulates stability many target mRNAs via binding AU-rich elements present in 3' untranslated region...
Growing studies have reported that pseudogenes play key roles in multiple human cancers. However, expression and of renal cell carcinoma remains absent.31 upregulated 16 downregulated were screened. Higher DUXAP8 DUXAP9 indicated poorer prognosis kidney cancer. 33 5 miRNAs predicted to potentially binding DUXAP9, respectively. miR-29c-3p was identified as the most potential based on expression, survival correlation analyses. 254 target genes forecast. 47 hub with node degree >= 10...
Increasing evidence has reported the critical roles of PIEZO1 in organism. However, knowledge human cancers is still inadequate.In silico analyses and experimental validation were performed to analyze PIEZO1's expression, prognostic values potential upstream/downstream mechanism breast cancer.PIEZO1 was significantly overexpressed cancer cell lines tissue samples. expression statistically positively associated with malignant progression short survival cancer. miR-10b-5p downregulation...
A comprehensive investigation of ubiquitin-conjugating enzyme E2I (UBE2I) in cancer is still insufficiency. In this study, we aimed to analyze its role and mechanism by combination bioinformatic analysis experimental validation.The expression profile UBE2I human cancers were obtained using GEPIA. Kaplan-Meier plotter was used assess the prognostic values diverse types cancer. ROC curve employed determine diagnostic hepatocellular carcinoma (HCC). The differences based on various...
Mounting evidences have demonstrated that HCC patients with or without cirrhosis possess different clinical characteristics, tumor development and prognosis. However, few studies directly investigated the underlying molecular mechanisms between non-cirrhotic cirrhotic HCC.The information RNA-seq data were downloaded from The Cancer Genome Atlas (TCGA) database. Differentially expressed genes (DEGs) of obtained by R software. Functional annotation pathway enrichment analysis performed...
Abstract Cervical cancer is closely linked to specific strains of human papillomavirus (HPV), notably HPV‐33 and HPV‐58, which exhibit a significant prevalence among women in China. Nevertheless, the codon usage bias HPV‐58 not well comprehended. The objective this research analyze patterns pinpoint primary factors that influence preference. overall preference for two HPV genotypes significant. Both codons end with A/U. GC3 content 25.43% ± 0.35%, it 29.44% 0.57%. Out 26 favored (relative...
Resistin is considered to be a risk factor for several types of cancer, but its functions are controversial and not well studied in lung cancer. The present study aimed investigate the expression resistin adenocarcinoma tissues, order evaluate association with clinicopathological characteristics cancer patients effects cells. A total 70 pairs tissues normal were collected immunohistochemistry was performed examine expression. overexpressed cells established by plasmid transfection A549 or...
The study of oocyte development holds significant implications in developmental biology. zebrafish (Danio rerio) has been extensively used as a model organism to investigate early processes from embryo. In zebrafish, oocytes are surrounded by single layer somatic granulosa cells. However, separating cells poses challenge, achieving pure is crucial for precise analysis. Although various methods have proposed isolate at different stages, current techniques fall short removing completely,...
Multiple myeloma (MM) is a common malignancy belonging to the hematological system. The translocation t(4;14)(p16.3;q32.3) critical cytogenetic change of MM, which presenting poor prognosis. specific microRNAs (miRNAs) that are involved in t(4;14) still unknown. Thus, main purpose this research was identify miRNAs positive myeloma.The expression profiles miRNA and messenger RNA (mRNA) t(4; 14) negative samples were obtained from gene omnibus data series. miRNA-mRNA regulatory network...
This study aims to build a prognostic model based on lactic acid metabolism-related genes (LMRGs) predict survival outcomes and tumor microenvironment status of Hepatocellular carcinoma (HCC) patients. The was used calculate riskscores clinical samples. Survival analysis Cox regression were conducted verify the independence reliability riskscore determine its significance in prognosis evaluation HCC. Additionally, we comprehensive mutation burden (TMB), immune cell infiltration, gene set...