A5101853317- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- RNA modifications and cancer
- Circular RNAs in diseases
- Microfluidic and Bio-sensing Technologies
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer Genomics and Diagnostics
- Drug Transport and Resistance Mechanisms
- Microtubule and mitosis dynamics
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
Army Medical University
2021
Southwest Hospital
2021
Second Affiliated Hospital of Xi'an Jiaotong University
2020
XinHua Hospital
2020
Chinese Academy of Sciences
2017-2018
Shanghai Institute of Materia Medica
2017-2018
University of Chinese Academy of Sciences
2017
Abstract Chemotherapeutic treatments against hepatocellular carcinoma (HCC) are necessary for both inoperable patients to improve prospects survival and surgery the outcome after surgical resection. However, multidrug resistance (MDR) is a major obstacle obtaining desirable results. Currently, increasing chemotherapy sensitivity of tumor cells or discovering novel inhibitors an effective therapeutic strategy solve this issue. In present study, we uncovered dual-inhibitory effect miR-338-5p:...
The development of resistance to 5-fluorouracil (5FU) chemotherapy is a major handicap for sustained effective treatment in peritoneal carcinomatosis (PC) colorectal cancer (CRC). Metabolic reprogramming adipocytes, component the tumor microenvironment and main composition peritoneum, plays significant role drug PC, with mechanisms being not fully understood. By performing metabolomics analysis, we identified glutamine (Gln), an important amino acid, inducing 5FU-triggered suppression CRC-PC...
Abstract BACKGROUND: It is very important to develop a highly efficient cerebrospinal fluid (CSF) detection system with diagnosis and prediction function, for which the of circulating tumor cells (CTCs) in CSF good choice. In contrast past use epithelial EpCAM as CTCs separation target, cytoplasm protein GFAP antibody was first selected construct highly-sensitive immunomagnetic liposome beads (IMLs). The validation efficiency this capturing brain tumors were measured both vitro vivo....
Abstract Background EMT confers increased metastatic potential andtheresistance to chemotherapiesto cancer cells.However, the precise mechanisms of EMT-related chemotherapy resistance remain unclear. Methods Anticancer effects were determined by MTT, soft agar, cell cycle, propidium iodide and Annexin V analysis. The effect drugs on tumor growth was assessed using patient-derived xenograft model nude mice model.Morphology cells observed phase contrast microscopy. Proteins interactions tested...