A5021057777- Pancreatic and Hepatic Oncology Research
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Pancreatitis Pathology and Treatment
- Chemokine receptors and signaling
- Gallbladder and Bile Duct Disorders
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- RNA modifications and cancer
- Neuroendocrine Tumor Research Advances
- Cancer Mechanisms and Therapy
- Intraperitoneal and Appendiceal Malignancies
- Congenital Anomalies and Fetal Surgery
- Vitamin D Research Studies
- Dupuytren's Contracture and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Macrophage Migration Inhibitory Factor
- IL-33, ST2, and ILC Pathways
- Minimally Invasive Surgical Techniques
Jiaxing University
2017-2024
Hunan Normal University
2023
Hunan Provincial People's Hospital
2023
Shanghai Jiao Tong University
2013
First Hospital of Jiaxing
2009
Abstract Early and accurate diagnosis of focal liver lesions is crucial for effective treatment prognosis. We developed validated a fully automated diagnostic system named Liver Artificial Intelligence Diagnosis System (LiAIDS) based on diverse sample 12,610 patients from 18 hospitals, both retrospectively prospectively. In this study, LiAIDS achieved an F1-score 0.940 benign 0.692 malignant lesions, outperforming junior radiologists (benign: 0.830-0.890, malignant: 0.230-0.360) being par...
Abstract Background Despite great advances in the prevention, diagnosis, treatment, and management regarding hepatocellular carcinoma (HCC), overall prognosis of HCC remains unfavorable. The expression profile, prognostic role, biological functions F‐box‐only protein 43 (FBXO43) remain unclear. Here, we determine profile value FBXO43 patients with HCC. Materials Methods A total 467 their clinicopathological data were collected from Second Affiliated Hospital Jiaxing University, Cancer Genome...
Pancreatic cancer (PC) ranks third in incidence and seventh mortality among cancers worldwide. CircZFR has been implicated various human cancers. Yet, how they affect PC progression is understudied. Herein, we demonstrated that circZFR was upregulated tissues cells, a feature correlated with the poor performance of patients PC. Functional analyses elucidated facilitated cell proliferation enhanced tumorigenicity Moreover, found metastasis by differentially regulating levels proteins related...
We focus on investigating the role of Parthenolide (Par), a small sesquiterpenoid molecule, in hepatocellular carcinoma (HCC) and its effective target.Highly-metastatic HCC cells, MHCC97-H, were divided into DMSO Par groups, which group was intervened at 5 10 mg/L doses. Cell viability assessed by CCK-8 assay. Transwell chamber assay performed to examine metastatic invasive abilities, while plate clone formation conducted detect ability. For analysis glucose uptake, glycolytic ability...
This study was aimed at investigating the expression and role of proprotein convertase subtilisin/kexin type (PCSK6) in inflammatory bowel disease (IBD). DSS induced mouse colitis mucosal barrier injury, down-regulation TJ proteins, improvement permeability, increases proportions Th1 M1 macrophages. After PCSK6 knockdown, KO mice improved relative to WT mice, protein levels increased, macrophages decreased. STAT1 inhibitor treatment also inhibited chronic mice. As revealed by in-vitro...
BACKGROUND The aim of this study was to explore the risk factors for post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and investigate effect octreotide combined with nonsteroidal anti-inflammatory drugs on preventing its occurrence. MATERIAL AND METHODS A total 139 patients undergoing ERCP in our hospital from May 2016 April 2017 were retrospectively analyzed, divided into an observation group (n=67) (octreotide + indomethacin) a control (n=72) (no preventive drugs)....
BACKGROUND Maternal embryonic leucine zipper kinase (MELK) has been implicated in various types of tumors, but its expression profile and clinicopathologic significance hepatocellular carcinoma (HCC) Chinese Han people remains unknown. Therefore, this study attempted to investigate the pattern MELK HCC tissues obtained from a population. MATERIAL AND METHODS The MELK, RNA protein levels, or disease-free human liver was evaluated using quantitative real-time polymerase chain reaction assays...
Anastomosing hemangioma (AH) is a rare subtype of benign that most commonly found in the genitourinary tract. Due to lack specific clinical and radiologic manifestations, it easily misdiagnosed preoperatively. Here, we report case AH arising from left renal vein was discovered incidentally confirmed pathologically, then describe its imaging characteristics point view review clinicopathologic features treatment.A 74-year-old woman admitted our department for retroperitoneal neoplasm measuring...
Spontaneous bladder rupture is relatively rare, and common causes of spontaneous include diverticulum, neurogenic dysfunction, gonorrhea infection, pelvic radiotherapy, etc. Urinary perforation caused by urinary catheterization mostly occurs during the intubation process.Here, we describe an 83-year-old male who was admitted with 26 h middle upper abdominal pain a history long-term catheterization. Physical examination computed tomography abdomen supported diagnosis diffuse peritonitis, most...
BACKGROUND:Sigmoid volvulus (SV) is a life-threatening condition occasionally seen in adults. Adult Hirschsprung's disease (HD)-related SV rarely complicated by difficult-to-control hypertension. In this report we present the case of an elderly man with rare constellation HD, SV, and refractory CASE REPORT:An 82-year-old had long-term constipation, moderate abdominal pain, progressive distension. A CT scan revealed typical "coffee bean sign". Blood pressure was abnormal high. Subsequently,...
Single-incision laparoscopic appendectomy (SILA) is usually performed using single-port instruments, which may restrict its development and application. This study explored the performance of transumbilical SILA (TSILA) suprapubic (SSILA) only conventional instruments compared them with three-hole/port (CLA).This retrospective included 174 patients who underwent CLA, TSILA, or SSILA for acute appendicitis at our hospital between June 2019 July 2021. Demographic data clinical outcomes were...
Our pre-investigation has revealed that long non-coding RNA (LncRNA) AL137789.1 the potential to predict survival of patients with pancreatic carcinoma (PCa). Accordingly, mechanism underlying implication in PCa is covered current study. The non-tumor and paired tumor tissues were collected. Kaplan-Meier curve was employed estimate high or low expression AL137789.1. proliferation, migration, invasion, cell cycle cells determined, cytotoxicity CD8+ T evaluated as well. Levels AL137789.1,...
This is the first report of an ROS1-CENPW fusion gene in pancreatic malignancies.A 77-year-old woman with a tumor and multiple liver metastases was admitted to our hospital. Genetic testing revealed presence gene, rare that has not been previously reported field cancer. The patient received crizotinib plus AG (albumin paclitaxel gemcitabine) chemotherapy. After treatment, patient's condition stabilized, her prognosis good.The treatment regimen used this case excellent option provides new...
Immunotherapy based on the tumor microenvironment is a feasible method for treating cancer; therefore, it necessary to investigate immune of pancreatic cancer and influencing factors microenvironment. Chemokines are an important factor affecting In present study, chemokines or chemokine receptors were screened identify those differentially expressed in compared with normal controls associated patient prognosis. that tissues initially using Gene Expression Omnibus database. Next, survival...
Abstract Background It remains unclear whether lymph node dissection is necessary for patients with N0 gallbladder carcinoma (GBC). The objective of this study was to evaluate the effect lymphadenectomy on prognosis GBC patients. secondary establish a prognostic model survival being founded large samples. Methods Patient data were obtained from database named SEER (Surveillance, Epidemiology, and End Results database) between 2010 2014. Analyses Kaplan–Meier multivariate Cox regression...
This study aims to build a prognostic model based on lactic acid metabolism-related genes (LMRGs) predict survival outcomes and tumor microenvironment status of Hepatocellular carcinoma (HCC) patients. The was used calculate riskscores clinical samples. Survival analysis Cox regression were conducted verify the independence reliability riskscore determine its significance in prognosis evaluation HCC. Additionally, we comprehensive mutation burden (TMB), immune cell infiltration, gene set...
The significance of CXCL5 in pancreatic cancer is unclear, although it has been implicated the malignant process many different types cancer. Research on impact immune cell infiltration and phenotype needed. This study aimed to examine connection between expression
Duplication of the appendix is an infrequent congenital malformation with a complex classification. The horseshoe subtype duplex and rarely reported in literature. Endometriosis common gynecological disease that occurs appendix. Moreover, combined endometriosis has not been previously reported.Here, we describe 44-year-old woman who was admitted 1-d history migratory lower right quadrant pain. Physical examination consistent signs acute appendicitis. patient underwent emergency exploratory...
Hepatocellular adenoma (HCA) is very rare and has a high misdiagnosis rate through clinical imaging examinations. We report case of giant HCA the left liver in young woman that was diagnosed by medical pathology.A 21-year-old admitted to our department for hepatic tumor measuring 22 cm × 20 10 completely replaced lobe. Her laboratory data only suggested mildly elevated function parameters C-reactive protein levels. A computed tomography (CT) scan showed mixed density tumor. Magnetic...
Objective To study the expressions of metadherin (MTDH),E-cadherin and β-catenin in tissues hepatocellular carcinoma (HCC),to investigate relationship between them clinical-pathological features,and to evaluate prognostic values after surgical resection for carcinoma.Methods The protein MTDH,E-cadherin were studied by immunohistochemistry tumor 107 HCC patients who underwent curative resection.The data correlated with data,tumor free time recurrence rate.Results Positive expression MTDH...
Objective To explore the value of endoscopic nasopancreatic drainage (NPD) in prevention post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) a high-risk population.Methods From April 2009 to February 2012,a total 105 cases PEP high risk population were collected and divided into non NPD group (n=58) (n=47) according situation during cholangiopancreatography(ERCP) operation.NPD was placed group,the head passed neck pancreas under X-ray.Nasobiliary or no assigned...