Cholangiocarcinoma (CCA), a rare yet notably aggressive cancer, has experienced surge in incidence recent years. Presently, surgical resection remains the most effective curative strategy for CCA. Nevertheless, majority of patients with CCA are ineligible removal at time diagnosis. For advanced stages CCA, combination gemcitabine and cisplatin is established as standard chemotherapy regimen. Despite this, treatment efficacy often hindered by development resistance. In times, immune...

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally, with poor prognosis due to late diagnosis and limited treatment options. In this study, we evaluated the expression ectonucleoside triphosphate diphosphohydrolase 8 (ENTPD8) in HCC tissues its clinical significance. Immunohistochemistry, The Cancer Genome Atlas (TCGA) data, single-cell analysis revealed reduced ENTPD8 levels liver cancer compared adjacent tissues, primarily expressed tumor cells within...

We summarize our experience of the diagnosis, surgical treatment, and prognosis solid pseudopapillary tumors (SPTs).We carried out a retrospective study clinical data from series 17 patients with SPT managed in two hospitals between October 2001 November 2011.All were female average age at diagnosis was 26.6 years (range 11 to 55 years). The tumor located body or tail ten patients, head five neck patients. median size 5.5 cm 2 10 cm). All had curative resections, including seven distal...

Abstract Background The molecular targets and associated mechanisms of hepatocellular carcinoma (HCC) have been widely studied, but the roles PDZK1 in HCC are unclear. Therefore, aim this study is to explore role HCC. Results It was found that expression tissues higher than paired paracancerous tissues. High with lymph node metastasis, degree differentiation, clinical stage. Upregulation cells affected their proliferation, migration, invasion, apoptosis, cell cycle, also induced PI3K/AKT...

This study was aimed at investigating the expression and role of proprotein convertase subtilisin/kexin type (PCSK6) in inflammatory bowel disease (IBD). DSS induced mouse colitis mucosal barrier injury, down-regulation TJ proteins, improvement permeability, increases proportions Th1 M1 macrophages. After PCSK6 knockdown, KO mice improved relative to WT mice, protein levels increased, macrophages decreased. STAT1 inhibitor treatment also inhibited chronic mice. As revealed by in-vitro...

Background. To explore the clinical characteristics of reactivation hepatitis B virus (HBV) in hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE). The pathological correlation prognosis and has been given detailed analyses our research. Methods. A total 108 related TACE-treated HCC data from January 2008 to 2016 was gleaned involved this retrospective analysis. lucubrate nuance survival rates between HBV reactivated group nonreactivated group, each patient...

Pancreatic cancer (PC) is a highly malignant tumor type with high early metastasis rate and no obvious symptoms. Gemcitabine first‑line chemotherapeutic drug for PC. Since there distinct method to determine the efficacy of chemotherapy gemcitabine in patients PC, purpose present study was whether positivity circulating cells (CTCs) advanced PC associated response explore CTCs may be used as predictor prognosis undergoing chemotherapy. First, immunomagnetic microspheres (magnetic beads; MIL)...

Pancreatic adenocarcinoma (PAAD) is a common and highly malignant tumor. The identification of prognostic biomarkers for PAAD could provide invaluable information clinical treatment. AMP‑activated protein kinase family member 5 (ARK5) the AMPK that mediates migration cells. In present study, ARK5 expression was evaluated using bioinformatics analysis in public datasets from Cancer Genome Atlas. levels tumor tissue were significantly increased, compared with matched non‑cancerous tissues....

The isogeometric analysis method (IGA) is a new type of numerical solving partial differential equations. Compared with the traditional finite element method, IGA based on geometric spline can keep model consistency between geometry and analysis, provide higher precision less freedom. However, huge stiffness matrix from subdivision progress still leads to solution efficiency problems. This paper presents multigrid (GMG) solve system IGA. extracts required computational data for process,...

Objective To investigate the prognostic value of multidrug resistance gene 1 ( MDR1 ) single nucleotide polymorphism (SNP) for transcatheterartery chemoembolization TACE ).Methods Samples were taken from 78 patients suffered hepatocellular carcinoma HCC ),C1236T,C3435T,G2677T/A SNP was detected by blood specimens adopting polymerase chain reaction-restricted fragment length (PCR-RFLP),the association between and clinical variables,prognosis analyzed.Meanwhile,80 obtained as control...

Objective To study the influence of norcantharidin on proliferation PANC-1 cells and protein kinase B (Akt) in human pancreatic cancer.Methods There were (NCTD) group control study.The killer effect,influence Akt expression detected by methyl thiazol tetrazolium (MTT) assay Immunohistochemical method,respectively.Results Norcantharidin showed inhibitory effect when NCTD concentration 4 μg/L for 24 h,inhibition rate above 35％,and along with extension time drug rise,Present a...

Objective To investigate the feasibility, efficacy, safety and economy of secondary splenic pedicle trisection method in removing schistosoma cirrhosis caused function. Methods Thirty patients receiving spleen structure amputation between July 2014 September 2016 were analyzed. Results Laparoscopic splenectomy with transaction was successfully performed 28 patients, whereas two Endo-GIAs used 2 patients. The average operation time (80 ± 20) min, operative blood loss (320 10) ml....

Objective To investigate the application of damage control surgery (DCS) concept in treatment pancreas trauma. Methods The clinical data 22 cases trauma from January 2009 to June 2016 were analyzed retrospectively, including degree injury, therapies and effect. Results Following DCS concept, 3 given conservative treatment, 19 treated by operation, debridement, hemostasis, suture, simple drainage preserved function; 21 cured 1 died; pancrestic fistula occurred 11 cases, abdominal...

Objective To observe the efficacy and adverse effects of low-dose gemcitabine chemotherapy in pancreatic cancer patients with mutant solute carrier family 29, member 1 (SLC29A1) gene T1288A. Methods A total 72 SLC29A1 T1288A were included this study. They randomly assigned to experimental group (low-dose gemcitabine, 600 mg/m2) control (standard-dose 000 mg/m2), both groups 36 patients. The curative effect reactions observed evaluated. Results There was no significant difference...

Objective To investigate the mutation of K-ras gene in gallbladder cancer and its correlation with clinicopathological prognosis. Methods DNA from 79 who underwent curative resection. The codon 12 13 were detected by nano capture probe. To analyze between clinical pathological indexes. significance on prognosis patients carcinoma also be analyzed. Results The total rate was 63.3% (50/79). There significant stages metastasis (P=0.003, P=0.000). cumulative one-year two-year...

Objectives To investigate the relationship between expression of hENT1 protein in pancreatic cancer and efficacy, adverse reactions prognosis gemcitabine. Methods The tissues 83 patients with diagnosed Department Hepatobiliary Pancreatic Surgery Jiaxing Second Hospital City Traditional Chinese Medicine from June 2013 to January 2016 were collected by endoscopic fine needle aspiration biopsy. The was detected immunohistochemistry, which divided into low group high group. According...

Abstract Objective : To investigate the clinical features of hepatitis B virus(HBV) reactivation after transcatheter arteriaI chemoembolization (TACE) treatment in patients with hepatocellular carcinoma (HCC), and analyze relationship between virus clinicopathological factors prognosis. Methods Clinical data 108 HCC treated by TACE from January 2006 to 2014 were retrospectively studied. The HBV analyzed differences survival rates group non-reactivation also compared. Results 42 (38.9%)...