Haokai Xu

ORCID: 0000-0002-1397-343X
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About
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Research Areas
  • Pancreatic and Hepatic Oncology Research
  • Cancer, Lipids, and Metabolism
  • Ferroptosis and cancer prognosis
  • Cancer-related molecular mechanisms research
  • Prostate Cancer Treatment and Research
  • Radiomics and Machine Learning in Medical Imaging
  • ECG Monitoring and Analysis
  • Cardiac electrophysiology and arrhythmias
  • 3D Printing in Biomedical Research
  • Cardiac Imaging and Diagnostics
  • Cancer Cells and Metastasis
  • RNA modifications and cancer
  • Renal cell carcinoma treatment
  • Metabolism, Diabetes, and Cancer
  • RNA Research and Splicing
  • Hepatocellular Carcinoma Treatment and Prognosis
  • Protein Tyrosine Phosphatases
  • Cancer Research and Treatments
  • FOXO transcription factor regulation

Chinese PLA General Hospital
2024

Ningbo No. 2 Hospital
2021

Bengbu Medical College
2020-2021

University of Nottingham Ningbo China
2021

Jiaxing University
2021

Pancreatic cancer (PAAD) is a common malignancy with poor survival rate. The identification of novel biomarkers could improve clinical outcomes for patients PAAD. Here we evaluated the expression and significance PPP1CB in was higher PAAD tissue than matched paracancerous (P < 0.05). We predicted network regulatory targets protein interaction partners PPP1CB, identified PPI consisting 39 node genes. 33 genes matching tissue. High ACTN4, ANLN, CLTB, IQGAP1, SPTAN1, TMOD3 associated improved...

10.1080/21655979.2021.1934243 article EN Bioengineered 2021-01-01

The present study was aimed to evaluate the expression profile of Zinc finger C3H1 domain-containing protein (ZFC3H1) using bioinformatic analysis public datasets from Cancer Genome Atlas database (TCGA). results showed that levels ZFC3H1 were notably lower than corresponding non-cancerous tissues in prostate adenocarcinoma (PRAD), and patients high ZFC3H1-expression group poor survival. We hypothesized low tumor tissue might have be an inhibitory effect on autoimmune system. predicted...

10.1080/21655979.2021.1965442 article EN Bioengineered 2021-01-01

This work aimed to study the diagnostic value of dynamic electrocardiogram (ECG) based on P wave detection algorithm for arrhythmia after hepatectomy in patients with primary liver cancer, and compare therapeutic effect different doses Betaloc. was introduced ECG automatic analysis, which can be used early diagnosis arrhythmia. Sixty cancer were selected as research objects. They randomly divided into control group, SD MD HD 15 cases each group. No Betaloc, low-dose (≤47.5 mg), medium-dose...

10.1155/2021/6034180 article EN Journal of Healthcare Engineering 2021-10-16

<title>Abstract</title> Background: Hepatocellular carcinoma (HCC) patients with multiple tumors have a poor prognosis and need more attention. Therefore, we aim to find an easy-available radiologic indicator that can differentiate for BCLC-A tumors. Methods: Magnetic resonance imaging (MRI) of received thermal ablation, laparoscopic hepatectomy, or hepatectomy combined ablation from five tertiary hospitals were collected. Tumor distribution (TD) was classified into three types:...

10.21203/rs.3.rs-4750918/v1 preprint EN cc-by Research Square (Research Square) 2024-08-17

Pancreatic cancer (PC) is a highly malignant tumor type with high early metastasis rate and no obvious symptoms. Gemcitabine first‑line chemotherapeutic drug for PC. Since there distinct method to determine the efficacy of chemotherapy gemcitabine in patients PC, purpose present study was whether positivity circulating cells (CTCs) advanced PC associated response explore CTCs may be used as predictor prognosis undergoing chemotherapy. First, immunomagnetic microspheres (magnetic beads; MIL)...

10.3892/etm.2021.10574 article EN Experimental and Therapeutic Medicine 2021-08-08

Pancreatic adenocarcinoma (PAAD) is a common and highly malignant tumor. The identification of prognostic biomarkers for PAAD could provide invaluable information clinical treatment. AMP‑activated protein kinase family member 5 (ARK5) the AMPK that mediates migration cells. In present study, ARK5 expression was evaluated using bioinformatics analysis in public datasets from Cancer Genome Atlas. levels tumor tissue were significantly increased, compared with matched non‑cancerous tissues....

10.3892/mmr.2020.11504 article EN cc-by-nc-nd Molecular Medicine Reports 2020-09-10

Abstract Background Prostate adenocarcinoma (PRAD) is a common tumor with high mortality rate, and advanced PRAD remains incurable. Exploring biomarkers related to prognosis could provide valuable information for clinical treatment. Zinc finger C3H1 domain-containing protein (ZFC3H1) large (1989 amino acids) that expressed in many human tumors, playing an important role RNA turnover translation. In the present study, we first evaluated expression profile of ZFC3H1 using bioinformatic...

10.21203/rs.3.rs-23147/v1 preprint EN cc-by Research Square (Research Square) 2020-05-27

Abstract Background: Pancreatic cancer is a malignant disease with difficult diagnosis and high mortality. The most common type pancreatic duct adenocarcinoma (PDAC). CXCL10 of great significance in the treatment immune diseases cancer. Here, we evaluated expression its clinical significance. Results: results TCGA database showed that tissues was higher than matched adjacent (P &lt;0.05). Patients had poor prognosis compared those low (P=0.0051).We found positively strongly correlated...

10.21203/rs.3.rs-966327/v1 preprint EN cc-by Research Square (Research Square) 2021-10-15
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