A5100760888- Cancer-related gene regulation
- MicroRNA in disease regulation
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Circular RNAs in diseases
- Lung Cancer Treatments and Mutations
- Glycosylation and Glycoproteins Research
- Galectins and Cancer Biology
- Blood properties and coagulation
- Extracellular vesicles in disease
- Cancer Mechanisms and Therapy
- Inflammatory Biomarkers in Disease Prognosis
- Signaling Pathways in Disease
- PI3K/AKT/mTOR signaling in cancer
- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Phagocytosis and Immune Regulation
- Prosthetics and Rehabilitation Robotics
- Wnt/β-catenin signaling in development and cancer
- Artificial Intelligence in Games
- Chromatography in Natural Products
- 14-3-3 protein interactions
- Natural Language Processing Techniques
Jiaxing University
2025
Qilu Hospital of Shandong University
2016-2023
First Affiliated Hospital of Zhengzhou University
2007-2021
Shandong University
2014-2021
Kunming Medical University
2020
Zhengzhou University
2014-2020
General Hospital of Shenyang Military Region
2014
Fifth Hospital In Wuhan
2009
Wuhan University
2009
Lac Courte Oreilles Ojibwa Community College
2007
Abstract Background Exosomal microRNAs (miRNAs or miRs) from bone marrow-derived mesenchymal stem cells (UCMSCs) have emerged as promising therapeutic strategies for cancer treatment. The current study aimed to elucidate the underlying mechanism of human umbilical cord (hUCMSCs)-derived exosomal miR-375 in esophageal squamous cell carcinoma (ESCC). Methods After determining expression and its putative target enabled homolog (ENAH) ESCC tissues cells, we tested effects their altered on...
Abstract Background Triple-negative breast cancer (TNBC) is a clinically aggressive subtype of with bad prognosis. Chemotherapy still the standard care for TNBC treatment. Circular RNAs (CircRNAs) have been recently discovered to be closely involved in initiation and development human cancers. Herein, we focus our attention on functions underlying mechanisms circUBE2D2 progression chemoresistance. Methods The expression circUBE2D2, miR-512-3p, cell division cycle associated 3 (CDCA3) mRNA...
Purpose: Lung cancer is the leading cause of related deaths worldwide.We have previously identified many differentially expressed genes (DEGs) from large scale pan-cancer dataset using Cross-Value Association Analysis (CVAA) method.Here we focus on Progestin and AdipoQ Receptor 4 (PAQR4), a member progestin adipoQ receptor (PAQR) family localized in Golgi apparatus, to determine their clinical role mechanism development non-small cell lung (NSCLC).Methods: The protein expression profile...
Kinesin family member 2a (KIF2A), a type of motor protein found in eukaryotic cells, is associated with development and progression various human cancers. The role KIF2A during breast cancer tumorigenesis was studied. Immunohistochemical staining, real time RT-PCR western blot were used to examine the expression tissues adjacent normal from patients. Patients' survival relation estimated using Kaplan–Meier multivariate analysis. Breast cell line, MDA-MB-231 study proliferation, migration...
The exponential growth of short-video content has ignited a surge in the necessity for efficient, automated solutions to video editing, with challenges arising from need understand videos and tailor editing according user requirements. Addressing this need, we propose an innovative end-to-end foundational framework, ultimately actualizing precise control over final editing. Leveraging flexibility generalizability Multimodal Large Language Models (MLLMs), defined clear input-output mappings...
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally, with poor prognosis due to late diagnosis and limited treatment options. In this study, we evaluated the expression ectonucleoside triphosphate diphosphohydrolase 8 (ENTPD8) in HCC tissues its clinical significance. Immunohistochemistry, The Cancer Genome Atlas (TCGA) data, single-cell analysis revealed reduced ENTPD8 levels liver cancer compared adjacent tissues, primarily expressed tumor cells within...
Elevated plasma fibrinogen levels are associated with tumor progression and poor outcomes in different cancer patients. The objective of this study was to investigate the clinical prognostic value preoperative patients operable breast cancer.Two hundred twenty-three diagnosed were retrospectively evaluated study. Plasma examined before treatment analyzed along patient clinicopathological parameters, disease-free survival (DFS) overall (OS). Both univariate multivariate analyses performed...
Comprehensive treatment based on chemotherapy is regarded as the first-line for patients with unresectable or metastatic esophageal squamous cell carcinoma (ESCC). However, chemoresistance common among ESCC. Therefore, there a need to explore new therapeutic strategies adjuvant drugs. One promising possibility use dietary agents that can increase tumor sensitivity In this study, we initially investigated antitumor activity of proteasome inhibitor MG132 in vitro and vivo. Effects enhancment...
Neoadjuvant chemotherapy has been established as standard treatments for advanced breast cancer among multidisciplinary therapies. A simple and instructive biomarker the postoperative recurrence metastasis is needed to evaluate therapeutic effect. Plasma fibrinogen level shown be associated with tumor progression poor outcomes in patients. This study aims further clinical prognostic value of plasma a patients receiving neoadjuvant chemotherapy. In this study, data 67 were retrospectively...
// Yi Zhang 1, 2, 3, 4, * , Ke Yao Chengcheng Shi Yanan Jiang Kangdong Liu 4 Song Zhao 3 Hanyong Chen 1 Kanamata Reddy Chengjuan 5 Xiaoyu Chang Joohyun Ryu Ann M. Bode Ziming Dong 2 Zigang The Hormel Institute, University of Minnesota, Austin, MN, USA Pathophysiology Department, Basic Medical College, Zhengzhou University, Henan, China First Affiliated Hospital China-US (Henan) Cancer These authors have contributed equally to this work Correspondence to: Dong, e-mail: zgdong@hi.umn.edu...
This study aimed to explore the underlying mechanism of linc01014 in oesophagus cancer gefitinib resistance. Gefitinib-resistant squamous cell carcinoma (ESCC gefitinibR) lines were constructed by using different treatment FLO-1, KYAE-1, TE-8 and TE-5 confirmed MTS50 proliferation assays. Expression was overexpressed/silenced FLO-1 cells followed treatment, then, apoptosis-associated markers Bax Bcl-2, PI3KCA PI3K signalling pathway determined Western blotting. MST50 morphology analyses...
The epidemiology of lung cancer changes with time, region, and population. pathological clinical characteristics patients primary bronchial were retrospectively analyzed to understand the epidemic trend in recent years.
Lung cancer is one of the most deadly human cancers and continues to be a major unsolved health problem worldwide. Here, we evaluate function Pbx1 in proliferation non-small-cell lung (NSCLC). In contrast with its known proliferative function, found that inhibits cells. particular, Pbx1-specific RNA interference resulted increased addition, histone H3 phosphorylation was also following inhibition expression. contrast, overexpression repressed cells inhibited DNA synthesis. Collectively, our...
Objectives: To study the molecular mechanism of arsenic trioxide-induced cell death on cerulein-stimulated AR42J cells. Methods: cells were incubated for 24 hours, and cerulein (10 nmol/L) different concentrations trioxide added another hours. The collected analyzed apoptosis oncosis by using rhodamine 123 propidium iodide staining, changes in genes that related to detected a gene chip. Results: After stimulation, was significantly increased addition number apoptotic cells, index reached its...
Heat shock protein 90α (HSP90α) has been confirmed to be upregulated in the blood various types of tumors and may therefore serve as a potential tumor marker. However, whether HSP90α exists nipple discharge remains unknown, its expression diagnostic value remain unclear. In this study, HSP90α, carcinoembryonic antigen (CEA), cancer 153 from 128 patients was measured. Receiver operating characteristic curve used assess HSP90α. Further, relationship with clinicopathological parameters breast...
Background Previous studies have shown that oncosis in malignant tumors might be related to cellular energy supply. The aim of this study was detect human esophageal squamous cell carcinoma (ESCC), and investigate its relationship with apoptosis microvessel density (MVD). Methods ESCC specimens were obtained from 30 patients after surgery. Transmission electron microscopy, TUNEL, immunohistochemistry used oncosis, apoptosis, MVD. relation MVD analyzed by ANOVA, t test, q test using SPSS...
Megakaryocytes (MKs) are one of the few cell types that become polyploid; however, mechanisms by which these cells designated to polyploid not fully understood. In this investigation, we successfully established two relatively synchronous models inducing Dami and CMK with SP600125. We found SP600125 induced polyploidization cells, concomitant phosphorylation ribosomal protein S6 kinase 1 (S6K1) at Thr421/Ser424 dephosphorylation Thr389. The was partially blocked H-89, a cAMP-dependent (PKA)...
We have previously shown that microRNAs (miRNAs) in nipple discharge are potential diagnostic biomarkers. In particular, exosomes present discharge. Herein, we sought to elucidate the protective role of on miRNAs and investigate stability encapsulated under degradative conditions. A novel TTMAAlPc-RNA complex method was used measure RNase concentration colostrum Quantitative real-time polymerase chain reaction performed test exogenous synthetic (cel-lin-4-5p cel-miR-2-3p) endogenous...
Dysregulation of PR (PRDI-BF1 and RIZ) domain protein 5 (PRDM5) expression has been shown to be associated with the progression many malignancies. Nevertheless, role underlying mechanism PRDM5 in oesophageal squamous cell carcinoma (ESCC) remain elusive. qRT-PCR was performed analyze mRNA expression, western blot used determine PRDM5, MMP-2, MMP-9, 14-3-3zeta, pan-Akt phosphorylated Akt expression. CCK-8 staining employed evaluate proliferation, while wound scratch assay Transwell were...