A5077760236- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- interferon and immune responses
- Cell death mechanisms and regulation
- Viral Infections and Immunology Research
- Chemical Synthesis and Reactions
- RNA modifications and cancer
- Chemical Synthesis and Analysis
- DNA Repair Mechanisms
- Herpesvirus Infections and Treatments
- Tissue Engineering and Regenerative Medicine
- Peptidase Inhibition and Analysis
- Cytokine Signaling Pathways and Interactions
- Immune Cell Function and Interaction
- Macrophage Migration Inhibitory Factor
- Cardiac Fibrosis and Remodeling
- Nuclear Receptors and Signaling
- Lung Cancer Treatments and Mutations
- NF-κB Signaling Pathways
- Machine Learning in Materials Science
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
Tianjin Medical University
2010-2024
Tianjin Anding Hospital
2024
First Affiliated Hospital of Zhengzhou University
2019-2020
Ministry of Education of the People's Republic of China
2010
Beijing Normal University
1992
Background: Radiotherapy is one of the most effective therapeutic strategies for cervical cancer patients, although radioresistance-mediated residual and recurrent tumors are main cause treatment failure. However, mechanism tumor radioresistance still elusive. DNA damage response pathways key determinants radioresistance. The purpose this study was to investigate role SND1 in cancer. Methods: A stable HeLa cell line with knockout (HeLa-KO) generated through a modified CRISPR/Cas9...
Our study aspires to understand the impact of miR-27b on myocardial fibrosis as well its functional mechanism. 12 days post ligation coronary artery in rats, expression peri-infarction region was elevated. Treating cultivated rat neonatal cardiac fibroblasts (CFs) with angiotensin II (AngII) also enhanced expression. Forced promoted proliferation and collagen production CFs, revealed by cell counting, MTT assay, quantitative reverse transcription-polymerase chain reaction. FBW7 found be...
Regulation of transcription requires cooperation between sequence-specific factors and numerous coregulatory proteins. In IL-4/IL-13 signaling several coactivators for STAT6 have been identified, but the molecular mechanisms STAT6-mediated gene are still not fully understood. Here we identified by proteomic approach that PTB-associated splicing factor (PSF) interacts with STAT6. intact cells interaction was observed only after IL-4 stimulation. The IL-4-induced tyrosine phosphorylation both...
This study aimed to explore the underlying mechanism of linc01014 in oesophagus cancer gefitinib resistance. Gefitinib-resistant squamous cell carcinoma (ESCC gefitinibR) lines were constructed by using different treatment FLO-1, KYAE-1, TE-8 and TE-5 confirmed MTS50 proliferation assays. Expression was overexpressed/silenced FLO-1 cells followed treatment, then, apoptosis-associated markers Bax Bcl-2, PI3KCA PI3K signalling pathway determined Western blotting. MST50 morphology analyses...
Abstract Background: Long non-coding RNAs are involved in the tumorigenesis of non-small cell lung cancer (NSCLC). This study aims to investigate whether LINC00476 affects proliferation, invasion, and migration NSCLC cells via SETDB1-activated Wnt/β-catenin pathway. Method: The expression LINC00476, SETDB1, Wnt1, β-catenin were determined tumor tissues paired adjacent tissues, as well lines bronchial epithelioid lines. Cell using counting kit-8 assay Transwell assay. relationship between...