A5038079761- Melanoma and MAPK Pathways
- Inflammatory mediators and NSAID effects
- Esophageal Cancer Research and Treatment
- Cardiovascular Health and Risk Factors
- Genetic factors in colorectal cancer
- Lipoproteins and Cardiovascular Health
- Tea Polyphenols and Effects
- Lung Cancer Treatments and Mutations
- Computational Drug Discovery Methods
- Cancer-related Molecular Pathways
- Cancer, Lipids, and Metabolism
- Tannin, Tannase and Anticancer Activities
- Healthcare Policy and Management
- Calpain Protease Function and Regulation
- Copper-based nanomaterials and applications
- Chemokine receptors and signaling
- Peroxisome Proliferator-Activated Receptors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer therapeutics and mechanisms
- Autophagy in Disease and Therapy
- Protein Kinase Regulation and GTPase Signaling
- COVID-19 impact on air quality
- Inflammatory Bowel Disease
- Esophageal and GI Pathology
- Protein Degradation and Inhibitors
Hebei University of Chinese Medicine
2025
Lanzhou University
2016-2025
Sichuan Center for Disease Control and Prevention
2023-2024
First Hospital of Jilin University
2024
Jilin University
2024
Ningxia Medical University
2024
Zhoushan Hospital
2022
University of Minnesota
2015-2020
Hormel (United States)
2015-2020
Changchun University of Science and Technology
2011
The polysaccharides of Crataegus pinnatifida (CPP) from ten habitats were prepared through water abstraction and alcohol precipitation. Subsequently, an analysis was conducted on their physicochemical properties molecular structure. establishment multidimensional fingerprints is based instrumental methods. Through the evaluation its antioxidant activity, spectrum-effect relationship studied. GalA in monosaccharide constitution components with a weight (Mw) ranging 2.07 × 106 Da to 5.57 have...
Lung cancer is the leading cause of cancer-related death worldwide. However, promising agents for lung prevention are still very limited. Identification preventive targets and novel effective urgently needed clinical applications. In this study, we found that fluvastatin targeted 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGCR), which a rate-limiting enzyme in mevalonate pathway, inhibited non-small cell (NSCLC) tumorigenesis. Initially, demonstrated HMGCR overexpressed...
Rationale: Melanoma is an aggressive tumor of the skin and drug resistance still a major problem in melanoma therapy. Novel targets effective agents to overcome resistant are urgently needed clinical Methods: Gene Expression Omnibus (GEO) database analysis, pathway enrichment survival rate analysis were utilized identify candidate target. An anchorage-independent cell growth assay, flow cytometry, Western blot, xenograft mouse model used study function Aurora kinase B (AURKB) both...
// Yi Zhang 1, 2, 3, 4, * , Ke Yao Chengcheng Shi Yanan Jiang Kangdong Liu 4 Song Zhao 3 Hanyong Chen 1 Kanamata Reddy Chengjuan 5 Xiaoyu Chang Joohyun Ryu Ann M. Bode Ziming Dong 2 Zigang The Hormel Institute, University of Minnesota, Austin, MN, USA Pathophysiology Department, Basic Medical College, Zhengzhou University, Henan, China First Affiliated Hospital China-US (Henan) Cancer These authors have contributed equally to this work Correspondence to: Dong, e-mail: zgdong@hi.umn.edu...
The most active anticancer component in green tea is epigallocatechin-3-gallate (EGCG). Protein interaction with EGCG a critical step for mediating the effects of on regulation various key molecules involved signal transduction. By using computational docking screening methods protein identification, we identified serine/threonine kinase, 90-kDa ribosomal S6 kinase (RSK2), as novel molecular target EGCG. RSK2 includes two catalytic domains N-terminal (NTD) and C-terminal (CTD) full...
Abstract Glioblastoma is one of the most aggressive and treatment‐resistant forms primary brain cancer, posing significant challenges in effective therapy. This study aimed to enhance effectiveness glioblastoma therapy by developing a unique nanomedicine composed Pluronic F127‐complexed PEGylated poly(glutamic acid)‐cisplatin (PLG‐PEG/PF127‐CDDP). PLG‐PEG/PF127‐CDDP demonstrated an optimal size 133.97 ± 12.60 nm, facilitating efficient cell uptake GL261 glioma cells. In vitro studies showed...
Abstract Malignant melanoma is an aggressive tumor of the skin and still lacks effective preventive therapeutic treatments. In melanoma, both BRAF/MEK/ERK PI3-K/AKT signaling pathways are constitutively activated through multiple mechanisms, which result in cell-cycle progression prevention apoptosis. Therefore, development novel strategies for targeting BRAF PI3K utmost importance. this study, we found that Ashitaba (Angelica keiskei) chalcones, 4-hydroxyderricin (4HD) xanthoangelol (XAG),...
BackgroundBarrett's esophagus (BE), a complication of gastroesophageal reflux disease (GERD), predisposes patients to esophageal adenocarcinoma (EAC). Reliable biomarkers for early detection and discovery potential drug targets are urgently needed improved BE EAC patient outcomes.MethodsPatient biopsy samples were evaluated COX1/2, thromboxane A2 synthase (TBXAS) expression. Circulating prostaglandins biosynthesis was determined using enzyme immunoassay kits. Anchorage-independent cell...
Abstract The identification of oncogenic biomolecules as drug targets is an unmet need for the development clinically effective novel anticancer therapies. In this study, we report first time that opsin 4/melanopsin (OPN4) plays a critical role in pathogenesis non–small cell lung cancer (NSCLC) and potential target. Our study has revealed OPN4 overexpressed human tissues cells, inversely correlated with patient survival probability. Knocking down expression suppressed cells growth induced...
The key functional molecules involved in inflammatory bowel disease (IBD) and IBD-induced colorectal tumorigenesis remain unclear. In this study, we found that the apoptosis repressor with caspase recruitment domain (ARC) protein plays critical roles IBD. ARC-deficient mice exhibited substantially higher susceptibility to dextran sulfate sodium (DSS)-induced IBD compared wild-type mice. burden induced conditions was inversely correlated CCL5 CXCL5 levels immune cells, especially CD4-positive...
Objective: To investigate the morbidity of chronic obstructive pulmonary diseases (COPD) in residents aged 30 years and above Sichuan Province, analyze effect smoking on risk COPD. Methods: From 2004 to 2008, people were randomly selected from Pengzhou, Province. All local 30-79 asked receive questionnaire survey, physical examination function testing, long-term follow-up determine Cox proportional hazard regression model was used relationship between Results: In 46 540 participants, current...
The specific mechanism by which rotenone impacts thoracic aortic autophagy and apoptosis is unknown. We aimed to investigate the regulatory effects of on in rat endothelial cells (RTAEC) via activation LKB1-AMPK-ULK1 signaling pathway elucidate molecular mechanisms vascular cells.
To investigate the morbidity of cerebrovascular disease among residents ≥30 years in Pengzhou, Sichuan Province, and analyze effect physical activity level on risk disease.
Goal: To investigate the current status of quality life postoperative patients with gynaecological tumours, and to analyse relevant factors affecting tumours. Method: One hundred fifty-three gynecological oncology who attended gynaecology departments three tertiary hospitals in Henan Province from June 2023 March 2024 were investigated by convenience sampling method. The patients' survival was through General Information Survey Scale Quality Life Score Scale. Results: measurement scale score...
Objective: To explore the influencing factors for non-alcoholic fatty liver disease (NAFLD) in Jinchang cohort, and provide scientific basis prevention control of NAFLD. Methods: A total 20 051 patients without at baseline survey met inclusion criteria cohort were selected as study subjects. Prospective Cox regression analysis used to investigate NAFLD, dose-response relationship between related biochemical indicators NAFLD risk was studied by restricted cubic spline method. Results: The...
Background: Barrett's esophagus (BE), a complication of gastroesophageal reflux disease (GERD), predisposes patients to esophageal adenocarcinoma (EAC). Reliable biomarkers for early detection and discovery potential drug targets are urgently needed improved BE EAC patient outcomes.Methods: Patient biopsy samples were evaluated COX1, COX2, thromboxane A2 synthase (TBXAS) expression. Circulating prostaglandins biosynthesis was determined using enzyme immunoassay kits. Anchorage-independent...
Abstract The most active anticancer component in green tea is epigallocatechin-3-gallate (EGCG). Protein interaction with EGCG a critical step mediating the effects of on regulation various key proteins involved signal transduction. By using computational docking screening methods for protein identification, we identified serine/threonine kinase, 90-kDa ribosomal S6 kinase (RSK2), as novel molecular target EGCG. RSK2 includes two catalytic domains N-terminal (NTD) and C-terminal (CTD) its...