A5112544071- Prostate Cancer Treatment and Research
- Evolution and Genetic Dynamics
- Horticultural and Viticultural Research
- Plant Gene Expression Analysis
- Animal Behavior and Reproduction
- Plant biochemistry and biosynthesis
- Evolutionary Game Theory and Cooperation
- Plant Molecular Biology Research
- Plant and animal studies
- Plant Physiology and Cultivation Studies
- Plant Stress Responses and Tolerance
- Photosynthetic Processes and Mechanisms
- Genetic diversity and population structure
- Bacteriophages and microbial interactions
- MicroRNA in disease regulation
- PARP inhibition in cancer therapy
- Ecology and Vegetation Dynamics Studies
- Migration, Ethnicity, and Economy
- Mathematical and Theoretical Epidemiology and Ecology Models
- Fermentation and Sensory Analysis
- Synthetic Organic Chemistry Methods
- Hormonal and reproductive studies
- Migration and Labor Dynamics
- Biochemical and biochemical processes
- Advanced Thermodynamics and Statistical Mechanics
Shanghai Jiao Tong University
2021-2024
China Agricultural University
2017-2024
Beijing Institute of Water
2023-2024
Guangxi University
2024
Chinese Academy of Sciences
2021-2024
Xinjiang Institute of Ecology and Geography
2021-2024
Northeast Agricultural University
2015-2024
Eisai (United States)
2004-2024
China Aerospace Science and Industry Corporation (China)
2023
Hunan Normal University
2023
BRD4 belongs to the bromodomain and extraterminal (BET) family of chromatin reader proteins that bind acetylated histones regulate gene expression. Pharmacological inhibition by BET inhibitors (BETi) has indicated antitumor activity against multiple cancer types. We show is essential for repair DNA double-strand breaks (DSBs) mediates formation oncogenic rearrangements engaging non-homologous end joining (NHEJ) pathway. Mechanistically, genome-wide are associated with enhanced acetylation...
Approximately 50% of prostate cancers are associated with gene fusions the androgen-regulated TMPRSS2 to oncogenic erythroblast transformation-specific (ETS) transcription factor ERG. The three-dimensional proximity and ERG genes, in combination DNA breaks, facilitates formation TMPRSS2-ERG fusions. However, origins breaks that underlie fusion far from clear. We demonstrate a role for inflammation-induced oxidative stress leading recurrent transcriptional status epigenetic features target...
Abstract Current thinking in life‐history theory and the biology of ageing suggests that rates, consequently life spans, evolve largely as a function trade‐offs with reproduction. While various evolutionary constraints are generally acknowledged to exist, their potential role determining rates is rarely considered. This review integrates three types information assess relative importance shaping rates: (a) empirical work on presence intraspecific trade‐offs; (b) theoretical factors limiting...
Abstract In prostate cancer, androgen deprivation therapy (ADT) enhances the cytotoxic effects of radiotherapy. This effect is associated with weakening DNA damage response (DDR) normally supported by receptor. As a significant number patients will fail combined ADT and radiotherapy, we hypothesized that DDR may be driven receptor splice variants (ARV) induced ADT. Investigating this hypothesis, found ARVs increase clonogenic survival cancer cells after irradiation in an ADT-independent...
Abstract Sexually antagonistic (SA) genetic variation—in which alleles favored in one sex are disfavored the other—is predicted to be common and has been documented several animal plant populations, yet we currently know little about its pervasiveness among species or population basis. Recent applications of genomics studies SA variation have highlighted considerable methodological challenges identification characterization genes, raising questions feasibility genomic approaches for...
The container shipping industry is receiving growing attention in driving the performance of global supply chains. This phenomenon has accelerated chain integration (SCI) within industry. Although SCI could offer numerous benefits, it often quoted to be implemented easier theory than practice. high failure rate that associated with not addressed literature. Grounded on resource-based view (RBV) theory, this paper aimed at identifying critical success factors (CSFs) and examining their...
Microbial communities display complex population dynamics, both in frequency and absolute density. Evolutionary game theory provides a natural approach to analyse model this complexity by studying the detailed interactions among players, including competition conflict, cooperation coexistence. Classic evolutionary models typically assume constant size, which often does not hold for microbial populations. Here, we explicitly take into account growth with frequency-dependent parameters, as...
Microbial communities are accompanied by a diverse array of viruses. Through infections abundant microbes, these viruses have the potential to mediate competition within community, effectively weakening competitive interactions and promoting coexistence. This is particular relevance for host-associated microbial communities, because diversity microbiota has been linked host health functioning. Here, we study interaction between two key members freshwater metazoan Hydra vulgaris The commensal...
Terpenoids are the major aroma components and generally exist as both free glycosidically-bound forms, of which nonvolatile glycosides account for a large fraction in grape berries. Our previous study has indicated that differential accumulation monoterpenyl Vitis vinifera 'Muscat blanc à Petit' between two regions is closely correlated to glucosyltransferase (VvGT14, XM_002285734.2) transcript abundance. However, it not been determined yet whether this correlation also exists other...
Parabens, a type of endocrine-disrupting chemicals, are widely used as antibacterial preservatives in food and cosmetics daily life. Paraben exposure has gained particular attention the past decades, owing to its harmful effects on reproductive function. Whether low-dose paraben may cause ovarian damage been ignored recently. Here, we investigated chronic propylparaben (PrPB) Female C57BL/6J mice were exposed PrPB at humanly relevant dose for 8 months. Our results showed that significantly...
An electrochemical oxidation-induced cyclization of ortho-alkyl-substituted azobenzenes has been developed. The direct benzylic C-H functionalization with respect to could proceed in the absence any catalyst or external chemical oxidant afford a number 2H-indazole derivatives moderate good yields. This protocol enables reuse byproduct same 2H-indazoles, thus significantly reducing pollution discharge synthetic chemistry.
Abstract Evolutionary dynamics of structural genetic variation in lineages hybrid origin is not well explored, although mutations may increase controlled crosses. We therefore tested whether variants accumulate a fish recent origin, invasive Cottus , relative to both parental species rhenanus and perifretum . Copy‐number exons 10,979 genes was assessed using comparative genome hybridization arrays. Twelve showed significantly higher copy numbers compared parents. This coincided with...
Norisoprenoids are important aromatic volatiles contributing to the pleasant floral/fruity odor in grapes and wine. They produced from carotenoids through cleavage of carotenoid dioxygenases (CCDs). However, underlying mechanisms regulating VvCCD expression remain poorly understood. In this study, we showed that VvCCD4b was positively correlated with accumulation β-damascenone, β-ionone, 6-methyl-5-hepten-2-one, geranylacetone, dihydroedulan I, total norisoprenoids developing two vintages...
The abscisic acid (ABA) increase and auxin decline are both indicators of ripening initiation in grape berry, norisoprenoid accumulation also starts at around the onset ripening. However, relationship between ABA, auxin, norisoprenoids remains largely unknown, especially transcriptome level. To investigate transcriptional posttranscriptional regulation ABA synthetic 1-naphthaleneacetic (NAA) on production, we performed time-series GC-MS RNA-seq analyses Vitis vinifera L. cv. Cabernet...
Resource competition is a major driver of dispersal: an emigrating individual leaves more resources to its kin. Existing models sex-biased dispersal rarely consider intersexual for resources. Instead, male reproductive success often solely assumed depend on female availability, implying tacit assumption that presence never depletes resources, such as food, are interest In reality, both and offspring typically consume their natal site before departing elsewhere, sexually dimorphic body sizes...
Glycosylated volatile precursors are important, particularly in wine grape berries, as they contribute to the final aroma wines by releasing aglycones during yeast fermentation and storage. Previous study demonstrated that VviGT14 was functioned a critical monoterpene glucosyltransferase berry, while transcriptional regulation mechanism of still unknown. Here we identified VviWRKY40 binding factor promoter both DNA pull-down one-hybrid screening, followed series vitro verification....
Abscisic acid (ABA) plays a key role in fruit development and ripening non-climacteric fruit. A variety of metabolites such as sugars, anthocyanins, fatty acids, several antioxidants, which are regulated by various phytohormones, important components quality grape. Here, grape cultivar "Ruiduhongyu" was used to investigate the relationship between endogenous phytohormones associated berry under exogenous ABA treatment. 500 mg/L significantly improved appearance parameters content many...