A5047059737- interferon and immune responses
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Herpesvirus Infections and Treatments
- Cytomegalovirus and herpesvirus research
- Cytokine Signaling Pathways and Interactions
- Heat shock proteins research
- Virus-based gene therapy research
- HIV Research and Treatment
- Advanced Topics in Algebra
- Algebraic structures and combinatorial models
- Viral Infections and Immunology Research
- Cervical Cancer and HPV Research
- Tuberculosis Research and Epidemiology
- Virology and Viral Diseases
- Effects of Radiation Exposure
- Tracheal and airway disorders
- Pneumonia and Respiratory Infections
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Signaling Pathways in Disease
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- Immune Response and Inflammation
- Respiratory viral infections research
Heinrich Heine University Düsseldorf
2023
Qilu Hospital of Shandong University
2021
Wuhan Institute of Virology
2016-2020
Chinese Academy of Sciences
2015-2020
University of Chinese Academy of Sciences
2019
Fudan University
2002-2016
State Key Laboratory of Genetic Engineering
2016
Arenaviruses are a large family of enveloped negative-strand RNA viruses that include several causative agents severe hemorrhagic fevers. Currently, there no FDA-licensed drugs to treat arenavirus infection except for the off-labeled use ribavirin. Here, we performed antiviral drug screening against Old World lymphocytic choriomeningitis virus (LCMV) using an FDA-approved library. Five candidates were identified, including mycophenolic acid, benidipine hydrochloride, clofazimine, dabrafenib,...
TLR2-dependent cellular signaling in Mycobacterium tuberculosis-infected macrophages causes apoptosis and inhibits class II major histocompatibility complex (MHC-II) molecules antigen processing, leading to evasion of surveillance. tuberculosis (Mtb) lipoproteins are an important Toll-like receptor (TLR) ligand, identified as specific components that mediate these effects. In this study, we characterized Mtb lipoprotein Rv1016c (lpqT) a cell wall associated-protein was exposed on the surface...
Lassa virus (LASV) is the causative agent of a fatal hemorrhagic fever in humans. The glycoprotein (GP) LASV mediates viral entry into host cells, and correct processing modification GP by factors prerequisite for replication. Here, using an affinity purification-coupled mass spectrometry (AP-MS) strategy, 591 proteins were identified as interactors GP. Gene ontology analysis was performed to functionally annotate these proteins, oligosaccharyltransferase (OST) complex highly enriched....
The family Arenaviridae includes several important human pathogens that can cause severe hemorrhagic fever and greatly threaten public health. As a major component of the innate immune system, RLR/MAVS signaling pathway is involved in recognizing viral components initiating antiviral activity. It has been reported arenavirus infection suppress response, NP Z proteins pathogenic arenaviruses disrupt signaling, thus inhibiting production type I interferon (IFN-I). However, recent studies have...
Herpes simplex virus type 1 (HSV-1) is widespread double-stranded DNA (dsDNA) that establishes life-long latency and causes diverse severe symptoms. The mechanisms of HSV-1 infection HSV-1's interactions with various host cells have been studied reviewed extensively. Type I interferons were secreted by upon HSV play a vital role in controlling proliferation. A few studies, however, focused on without the presence interferon (IFN) signaling. In this study, HEK 293T low toll-like receptor...
The rather few cases of humans infected by HIV-1 N, O, or P raise the question their incomplete adaptation to humans. We hypothesized that early postentry restrictions may be relevant for impaired spread these HIVs. One best-characterized species-specific restriction factors is TRIM5α. M can escape human (hu) TRIM5α binding cyclophilin A (CYPA, also known as PPIA, peptidylprolyl isomerase A) so-called CYPA-binding loop its capsid protein. How non-M HIV-1s interact with huTRIM5α ill-defined....
Enterovirus 71 (EV71) is one of the leading causes hand, foot and mouth disease with neurological complications in some cases. To study pathogenesis EV71 infection, large-scale analyses infected cells have been performed. However, most these studies employed rhabdomyosarcoma (RD) or used transcriptomic strategy. Here, we performed SILAC-based quantitative proteomic analysis EV71-infected U251 cells, a human glioma cell line. A total 3125 host proteins were quantified, which 451...
Sendai virus (SeV) is an enveloped nonsegmented negative‐strand RNA that belongs to the genus Respirovirus of Paramyxoviridae family. As a model pathogen, SeV has been extensively studied define basic biochemical and molecular biologic properties paramyxoviruses. In addition, SeV‐infected host cells were widely employed uncover mechanism innate immune response. To identify proteins involved in infection process or SeV‐induced response process, system‐wide evaluations SeV–host interactions...
Heat shock protein 90α (HSP90α) has been confirmed to be upregulated in the blood various types of tumors and may therefore serve as a potential tumor marker. However, whether HSP90α exists nipple discharge remains unknown, its expression diagnostic value remain unclear. In this study, HSP90α, carcinoembryonic antigen (CEA), cancer 153 from 128 patients was measured. Receiver operating characteristic curve used assess HSP90α. Further, relationship with clinicopathological parameters breast...