A5073577367- Glioma Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Cancer Treatment and Pharmacology
- Cell Image Analysis Techniques
- Medical Image Segmentation Techniques
- Geophysical Methods and Applications
- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Image and Signal Denoising Methods
- Advanced Image Processing Techniques
- Muscle Physiology and Disorders
- Radiomics and Machine Learning in Medical Imaging
- Microwave Imaging and Scattering Analysis
- Ferroptosis and cancer prognosis
- Seismic Imaging and Inversion Techniques
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer-related Molecular Pathways
- Medical Imaging Techniques and Applications
- Zebrafish Biomedical Research Applications
- Seismic Waves and Analysis
- Advanced Fluorescence Microscopy Techniques
- Image Processing Techniques and Applications
- Cell death mechanisms and regulation
- Cellular Mechanics and Interactions
- Brain Tumor Detection and Classification
China Medical University
2012-2025
Shanghai Jiao Tong University
2018-2025
Zhejiang University
2011-2025
Shanghai Eye Disease Prevention & Treatment Center
2022-2025
Shanghai Clinical Research Center
2024-2025
Brigham and Women's Hospital
2015-2024
Harvard University
2015-2024
First Affiliated Hospital of Zhengzhou University
2024
East China Normal University
2021-2023
National Yunlin University of Science and Technology
2022
Amyloid-β (Aβ) deposits have been identified as key players in the progression of Alzheimer's disease (AD). Recent evidence indicates that probably precede and induce neuronal atrophy. Therefore, methods enable monitoring pathology before clinical symptoms are observed would be beneficial for early AD detection. Here, we report design, synthesis, testing a curcumin-derivatized near-infrared (NIR) probe, CRANAD-2. Upon interacting with Aβ aggregates, CRANAD-2 undergoes range changes, which...
We demonstrate the use of coherent anti-Stokes Raman scattering (CARS) microscopy to image brain structure and pathology ex vivo. Although non-invasive clinical imaging with CT, MRI PET has transformed diagnosis neurologic disease, definitive pre-operative distinction neoplastic benign pathologies remains elusive. Definitive still requires biopsy in a significant number cases. CARS microscopy, nonlinear, vibrationally-sensitive technique, is capable high-sensitivity chemically-selective...
We present a new method in image segmentation that is based on Otsu's but iteratively searches for subregions of the segmentation, instead treating full as whole region processing. The iterative starts with threshold and computes mean values two classes separated by threshold. Based values, separates into three standard does. first are determined foreground background they will not be processed further. third class denoted to-be-determined (TBD) at next iteration. At succeeding iteration,...
<h3>BACKGROUND AND PURPOSE:</h3> Patient survival in high-grade glioma remains poor, despite the recent developments cancer treatment. As new chemo-, targeted molecular, and immune therapies emerge show promising results clinical trials, image-based methods for early prediction of treatment response are needed. Deep learning models that incorporate radiomics features promise to extract information from brain MR imaging correlates with prognosis. We report initial production a combined deep...
Background Approximately one‐fourth of all cancer metastases are found in the brain. MRI is primary technique for detection brain metastasis, planning radiotherapy, and monitoring treatment response. Progress tumor now requires new or growing at small subcentimeter size, when these therapies most effective. Purpose To develop a deep‐learning‐based approach finding metastasis on MRI. Study Type Retrospective. Sequence Axial postcontrast 3D T 1 ‐weighted imaging. Field Strength 1.5T 3T....
Abstract Early and accurate diagnosis of focal liver lesions is crucial for effective treatment prognosis. We developed validated a fully automated diagnostic system named Liver Artificial Intelligence Diagnosis System (LiAIDS) based on diverse sample 12,610 patients from 18 hospitals, both retrospectively prospectively. In this study, LiAIDS achieved an F1-score 0.940 benign 0.692 malignant lesions, outperforming junior radiologists (benign: 0.830-0.890, malignant: 0.230-0.360) being par...
Genomic alterations of the epidermal growth factor receptor (EGFR) gene play a crucial role in pathogenesis glioblastoma multiforme (GBM). By systematic analysis GBM genomic data, we have identified and characterized novel exon 27 deletion mutation occurring within EGFR carboxyl-terminus domain (CTD), addition to identifying additional examples previously reported mutations this region. We show that GBM-derived CTD mutants are able induce cellular transformation vitro vivo absence ligand...
In recent years, due to the rise in population and aging, prevalence of neurological diseases is also increasing year by year. Among these patients with Parkinson’s disease, stroke, cerebral palsy, other symptoms, dysarthria often appears. If are not quickly detected treated, it easy cause difficulties disease course management. When symptoms worsen, they can affect patient’s psychology physiology. Most past studies on detection used machine learning or deep models as classification models....
Abstract Background Vedolizumab (VDZ) is a humanized monoclonal antibody, that selectively targets α4β7 integrin and approved for Crohn’s disease (CD) Ulcerative colitis (UC). Previous studies demonstrated better efficacy of VDZ in bio-naïve pts with CD, however, there lack sufficient data Chinese pts. VALUE study (NCT04872491) prospective, multicenter, single-armed observational evaluating the safety effectiveness UC CD patients (pts). Methods This subgroup second interim analysis trial was...
Aims To evaluate the potential causal role of sleep traits (STs) on diabetic retinopathy (DR). Methods The cross-sectional study included 23,851 patients with type 2 diabetes from UK Biobank and used multivariate logistic models to investigate observational association between STs DR. Genetic correlation analysis two-sample Mendelian randomization (MR) were conducted using ST data DR FinnGen consortium genetic associations Results Patients who experienced daytime sleepiness often/all time...
We introduce a combination of high-dimensional analysis variance (HANOVA) and sequential probability ratio test (SPRT) to detect buried objects from an array ground-penetrating radar (GPR) surveying region interest in progressive manner. Using HANOVA, we exploit the transient characteristic GPR signals time domain extract information about at fixed positions array. Based on output SPRT is employed make detection decisions recursively as moves downtrack. The method on-line implementable low...
We have previously shown that CLDN4 (encoding claudin-4), a cell tight junction (TJ) protein, is highly expressed in human epithelial ovarian carcinomas (EOC) but undetectable normal ovaries. has been identified as specific receptor for C terminus of Clostridium perfringens enterotoxin (C-CPE), nontoxic molecule may disrupt TJ barrier function and enhance cellular absorption. The purpose this study was to determine the potential clinical applications C-CPE its effects on expression EOC.Using...
In eukaryotic cells, when exposed to certain types of stress including hypoxia, eIF2α is phosphorylated by several kinases protein kinase R (PKR) and PKR-like endoplasmic reticulum (PERK). Subsequently, translation stopped granules (SGs) are formed. Cancer cells form SGs under hypoxia. accumulate apoptosis-related molecules play anti-apoptotic roles. Thus, hypoxia-induced SG formation contributes drug resistance in cancer cells. For this reason, inhibition expected be beneficial therapy. To...
Optimized versions of frequency-wavenumber (F-K) migration methods are introduced to better focus ground-penetrating radar (GPR) data in applications shallow subsurface object localization, e.g., landmine remediation. Migration based on the wave equation and operate by backpropagating received into earth so as localize buried objects. Traditional F-K is an underlying assumption that wavefields propagate a homogeneous medium. The presence rough air-ground interface GPR case degrades...