A5100453390- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Spine and Intervertebral Disc Pathology
- Spinal Fractures and Fixation Techniques
- Lung Cancer Treatments and Mutations
- Pancreatic and Hepatic Oncology Research
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Medical Imaging and Analysis
- Soft Robotics and Applications
- Ubiquitin and proteasome pathways
- Surgical Simulation and Training
- Colorectal and Anal Carcinomas
- Orthopaedic implants and arthroplasty
- Lung Cancer Diagnosis and Treatment
- Anatomy and Medical Technology
- Head and Neck Cancer Studies
- Cervical and Thoracic Myelopathy
- Metabolism, Diabetes, and Cancer
- Thyroid and Parathyroid Surgery
- Facial Trauma and Fracture Management
- Surgical Sutures and Adhesives
- Garlic and Onion Studies
- Intraperitoneal and Appendiceal Malignancies
Second Military Medical University
2024
Yangzhou University
2018-2024
Jiangsu Provincial Center for Disease Control and Prevention
2024
Changhai Hospital
2024
Zhejiang Chinese Medical University
2023
Shanghai University of Traditional Chinese Medicine
2022
Tianjin Medical University
2013-2022
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2022
Hebei North University
2022
Wuhan Union Hospital
2021
A high concentration of Zearalenone (ZEA) will perturb the differentiation germ cells, and induce a death but toxic mechanism molecular remain unclear. The Sertoli cells (SCs) play an irreplaceable role in spermatogenesis. In order to explore potential ZEA male reproductive toxicity, we studied effects on cell proliferation, cell-cycle distribution, cell-cycle-related proteins autophagy-related pathway PI3K/Akt/mTOR signaling primary cultured rats SCs, autophagy PI3K/AKT/m TOR SCs arrest...
Fibronectin (FN) is a high-molecular-weight glycoprotein component of the extracellular matrix involved in cell adhesion, migration, metastasis, proliferation and differentiation, as well embryogenesis, wound healing, blood coagulation. Considerable recent research has established that tumor expression FN closely associated with formation development disease prognosis. However, mechanisms underlying this relationship have remained unclear. The aim study was to investigate protein esophageal...
Abstract Cholesterol metabolism is highly correlated with risks of pancreatic ductal adenocarcinoma (PDAC). Nevertheless, the underlying mechanisms activation cholesterol biogenesis remain inconclusive. KIF11 a key component bipolar spindle and expresses in various malignancies. However, its functional role PDAC tumorigenesis still unclear. This study aims to elucidate oncogenic functions stimulating metabolism, thereby driving progression. We utilized bioinformatics analysis identify that...
Several studies have examined association between human papillomaviruses (HPV) and esophageal cancer, but results been inconsistent. This is the first prospective study to investigate associations α, β γ HPV detection in oral cavity risk of cancer.
The standard radiation dose 50.4 Gy with concurrent chemotherapy for localized inoperable esophageal cancer as supported by INT-0123 trail is now being challenged since a above 50 has been successfully administered an observable dose-response relationship and insignificant untoward effects. Therefore, to ascertain the treatment benefits of different doses, we performed meta-analysis 18 relative publications. According our findings, between 70 appears optimal patients who received ≥ 60 had...
Aims to decrease the work load in operation and enhance robot automatic level, this paper proposes a new kinematics method of 3D visual window for Laparoscopic Minimally Invasive Surgical Robotic System (LMISRS) based on model laparoscope arm motion micro devices 2 instrument arms view angle window, thus establishing algorithm through analysis viewpoint control, verifying it with sample.
Abstract Various synthetic bone substitutes are not suitable for reconstructing critical‐size defects. This study tested whether a bioglass‐β‐tricalcium phosphate (β‐TCP) monoblock is effective repairing segmental defects if combined with vascularized periosteal flap and morphogenetic protein (BMP)‐2. A femoral osteotomy gap size of 20 mm was created stabilized using plate in 40 rabbits.The defect left untreated (group A) or repaired B), C), BMP‐2 D). Bone regeneration, vascularization...
SUMMARY This paper proposes a new effective kinematics method based on the dynamic visual window (DVW) for surgical robot that is equipped with two instrument arms and one laparoscope arm, to enable doctors achieve operations their habits under laparoscopic environment. The problem of consistency principle between doctor's window's feedback master–slave solved. models robotic are established, methods DVW proposed according inverse respect coordinate system. Finally, verified by simulation...
The 8th edition of the American Joint Committee on Cancer (AJCC)/Union for International Control (UICC) staging system released in 2017 reclassified pTNM stage early esophageal adenocarcinoma from IA 7th to and IB IC. In this study, we analyzed reliability new through clinical data analysis.We selected patient Surveillance, Epidemiology, End Results (SEER) database. From 2004 2014, a total 714 patients were included study divided into groups representing (n=84), (n=386) IC (n=244) according...
This is the first report of an ROS1-CENPW fusion gene in pancreatic malignancies.A 77-year-old woman with a tumor and multiple liver metastases was admitted to our hospital. Genetic testing revealed presence gene, rare that has not been previously reported field cancer. The patient received crizotinib plus AG (albumin paclitaxel gemcitabine) chemotherapy. After treatment, patient's condition stabilized, her prognosis good.The treatment regimen used this case excellent option provides new...
Abstract Objective To observe the surgical index at different learning stages of thoraco-laparoscopic esophagectomy in prone position for esophageal cancer and to investigate curve this procedure. Methods Sixty esophagectomies conducted by same group surgeons between January 2014 December 2015 were retrospectively analyzed. The surgeries divided into 5 groups, A, B, C, D, E, chronological order. duration surgery, intraoperative blood loss, total number lymph nodes removed, rate conversion...
Objective To evaluate the effect and clinical significance of adrenomedulin(ADM) urotensin-Ⅱ(UⅡ) on pulmonary hypertension(PH),by detecting their levels patients with congenital heart disease hypertension.Methods 52 who had left-to-right shunt were selected randomly.52 divided three groups according to artery systolic pressure(PASP):group A was not hypertension(PASP30 mm Hg,(n=17));group B mild hypertension(PASP30-49 mmHg,n=18);group C moderate severe hypertension(PASP≥50 Hg,n=17).The plasma...
Abstract Background It has been documented that Helicobacter hepaticus produces a nickel‐containing hydrogen‐oxidizing hydrogenase enzyme, which is necessary for hydrogen‐supported amino acid uptake. Although H. infection shown to promote liver inflammation and fibrosis in BALB/c mice, the impact of on progression induced by not explored. Materials Methods mice were inoculated with mutant (ΔHyaB) or wild type (WT) 3B1 12 24 weeks. colonization, hepatic histopathology, serum biochemistry,...
Autophagy is considered to be closely associated with cancer, functioning as either an anticancer or procancer mechanism depending on the cancer stage. However, prognostic value of autophagy papillary renal cell carcinoma (pRCC) remains unclear. In this study, our purpose was determine autophagy-related mRNA signature predict overall survival patients pRCC.A total 284 pathologic confirmed pRCC in The Cancer Genome Atlas (TCGA) dataset were recruited and included. We choose who have smoked...
For cervical and higher-level esophageal tumors, the choice of anastomosis or thoracic is still controversial. The goal this study was to explore optimal surgical approach for cervicothoracic squamous tumors.We retrospectively analyzed 3,802 consecutive patients with cell tumors in Nanjing Drum Tower Hospital from Jan 2001 2017. Twenty-six twenty-eight were evaluated.The group exhibited a greater number resected lymph nodes (36.5±7.3 vs. 19.9±5.7, P<0.001). In addition, higher recurrence...