A5033486450- Asymmetric Hydrogenation and Catalysis
- Catalytic C–H Functionalization Methods
- Organoboron and organosilicon chemistry
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Catalytic Cross-Coupling Reactions
- Phosphodiesterase function and regulation
- Carbon dioxide utilization in catalysis
- Organometallic Complex Synthesis and Catalysis
- Cholinesterase and Neurodegenerative Diseases
- Synthetic Organic Chemistry Methods
- Chemical Synthesis and Analysis
- Receptor Mechanisms and Signaling
- Peroxisome Proliferator-Activated Receptors
- Crystallography and molecular interactions
- Advanced Battery Materials and Technologies
- Advancements in Battery Materials
- Asymmetric Synthesis and Catalysis
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Synthetic Organic Chemistry
- Catalysis and Oxidation Reactions
- Boron Compounds in Chemistry
- Cholesterol and Lipid Metabolism
- ZnO doping and properties
- Protein Tyrosine Phosphatases
Shanghai Institute of Organic Chemistry
2016-2025
Chinese Academy of Sciences
2016-2025
University of Chinese Academy of Sciences
2017-2025
Nanjing University
2025
State Key Laboratory of Organometallic Chemistry
2018-2025
South China Normal University
2025
Beijing Institute of Genomics
2022-2024
Collaborative Innovation Center of Chemistry for Energy Materials
2013-2024
Xiamen University
2009-2024
East China Normal University
2019-2024
With petroleum supplies dwindling, there is increasing interest in selective methods for transforming other carbon feedstocks into hydrocarbons suitable transportation fuel. We report the development of highly productive, well-defined, tandem catalytic systems metathesis n-alkanes. Each system comprises one molecular catalyst (a "pincer"-ligated iridium complex) that effects alkane dehydrogenation and olefin hydrogenation, plus a second (molecular or solid-phase) metathesis. The all show...
This review covers the advance in development of Fe, Co, and Ni catalysts for alkene hydrosilylation reaction, as well related dehydrogenative silylation reaction. The is an important reaction synthesis alkylsilanes that has widespread applications numerous silicon-based materials, decades, this transformation been relying on use Pt catalysts. Recently, high abundance low cost, coupled with environmentally benign nature base metals have stimulated enormous research first-row transition-metal...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSlow- and tight-binding inhibitors of the 85-kDa human phospholipase A2Ian P. Street, Hung Kuei Lin, France Laliberte, Farideh Ghomashchi, Zhaoyin Wang, Helene Perrier, Nathalie M. Tremblay, Zheng Huang, Philip K. Weech, Michael H. GelbCite this: Biochemistry 1993, 32, 23, 5935–5940Publication Date (Print):June 15, 1993Publication History Published online1 May 2002Published inissue 15 June...
A catalytic alkane metathesis provides a mild and selective degradation of polyethylene wastes into valuable fuels waxes.
We report the synthesis of cobalt complexes novel iminopyridine–oxazoline (IPO) ligands and their application to asymmetric hydroboration 1,1-disubstituted aryl alkenes. The new catalysts afforded α-alkyl-β-pinacolatoboranes with exclusive regioselectivity in high yields up 99.5% ee. Furthermore, we have applied this method an efficient naproxen.
Precious iron: A new PNN iron complex has been developed for use in an iron-catalyzed alkene hydroboration reaction under mild conditions. The environmentally friendly and earth-abundant catalyst system is superior to precious-metal systems terms of efficiency selectivity α-olefin hydroborations with pinacolborane.
Abstract An extremely efficient cobalt catalyst for the hydroboration of both vinylarenes and aliphatic α‐olefins with pinacolborane is described, providing anti‐Markovnikov products excellent regio‐ chemoselectivity, broad functional‐group tolerance, high turnover numbers (up to 19 800). The alkene route further extended a two‐step, one‐pot cross‐coupling alkylboronates aryl chlorides.
A series of new pincer iron complexes with electron-donating phosphinite-iminopyridine (PNN) ligands has been prepared and characterized. These compounds are efficient selective catalysts for the anti-Markovnikov alkene hydrosilylation primary, secondary, tertiary silanes. More importantly, system exhibits unprecedented functional group tolerance reactive groups such as ketones, esters, amides. Furthermore, iron-catalyzed was successfully applied to synthesis a valuable insecticide,...
Abstract A complementary set of base metal catalysts has been developed for regiodivergent alkene hydrosilylations: iron complexes phosphine‐iminopyridine are selective anti ‐Markovnikov hydrosilylations (linear/branched up to >99:1), while the cobalt bearing same type ligands provide an unprecedented high level Markovnikov selectivity (branched/linear >99:1). Both systems exhibit efficiency and wide functional group tolerance.
Abstract The strategic carbon‐to‐silicon substitution at a stereogenic center can produce chiral silanes with significantly improved properties relative to their carbon congeners. We herein report an unprecedented cobalt‐catalyzed asymmetric hydrosilylation of unsymmetric alkynes dihydrosilanes that furnishes silicon‐stereogenic vinylhydrosilanes high regio‐ and enantioselectivity. absolute configurations the products were determined by chiroptical methods in combination DFT calculations....
The value of catalytic dehydrogenation aliphatics (CDA) in organic synthesis has remained largely underexplored. Known homogeneous CDA systems often require the use sacrificial hydrogen acceptors (or oxidants), precious metal catalysts, and harsh reaction conditions, thus limiting most existing methods to non- or low-functionalized alkanes. Here we describe a visible-light-driven, dual-catalyst system consisting inexpensive organophotoredox base-metal catalysts for room-temperature,...
A combination of pharmacological and genetic approaches was used to determine the role type 4 cAMP-specific cyclic nucleotide phosphodiesterase (PDE4) in reversing α2-adrenoceptor–mediated anesthesia, a behavioral correlate emesis non-vomiting species. Among family-specific PDE inhibitors, PDE4 inhibitors reduced duration xylazine/ketamine–induced anesthesia mice, with no effect on pentobarbital-induced anesthesia. The rank order tested 6-(4-pyridylmethyl)-8-(3-nitrophenyl)quinoline (PMNPQ)...
A combination of pharmacological and genetic approaches was used to determine the role type 4 cAMP-specific cyclic nucleotide phosphodiesterase (PDE4) in reversing α2-adrenoceptor–mediated anesthesia, a behavioral correlate emesis non-vomiting species. Among family-specific PDE inhibitors, PDE4 inhibitors reduced duration xylazine/ketamine–induced anesthesia mice, with no effect on pentobarbital-induced anesthesia. The rank order tested 6-(4-pyridylmethyl)-8-(3-nitrophenyl)quinoline (PMNPQ)...
Alendronate (ALN), an aminobisphosphonate used in the treatment of osteoporosis, is a potent inhibitor bone resorption. Its molecular target still unknown. This study examines effects ALN on activity osteoclast protein-tyrosine phosphatase (PTP; protein-tyrosine-phosphate phosphohydrolase, EC 3.1.3.48), called PTPepsilon. Using osteoclast-like cells generated by coculturing mouse marrow with calvaria osteoblasts, we found cloning and RNA blot hybridization that PTPepsilon highly expressed...
Catalytic alkane dehydrogenation is a reaction with tremendous potential for application. We describe highly active PSCOP-pincer iridium catalyst transfer of cyclic and linear alkanes. The alkanes occurs under relatively mild conditions high regioselectivity α-olefin formation. In addition, the system very effective in heterocycles to form heteroarenes olefinic products.
The first general catalytic approach to effecting transfer hydrogenation (TH) of unactivated alkenes using ethanol as the hydrogen source is described. A new NCP-type pincer iridium complex (BQ-NCOP)IrHCl containing a rigid benzoquinoline backbone has been developed for efficient, mild TH C–C multiple bonds with ethanol, forming ethyl acetate sole byproduct. wide variety alkenes, including multisubstituted alkyl aryl and heteroatom-substituted well O- or N-containing heteroarenes internal...
The potential use of SCD inhibitors for the chronic treatment diabetes and dyslipidemia has been limited by preclinical adverse events associated with inhibition in skin eye tissues. To establish a therapeutic window, we embarked on designing liver-targeted utilizing molecular recognition liver-specific organic anion transporting polypeptides (OATPs). In doing so, set out to target inhibitor organ believed be responsible efficacy (liver) while minimizing its exposure tissues mechanism-based...
The selective preparation of 1,1,1-tris(boronates) from vinylarenes and bis(pinacolato)diboron is described. reactions occur at ambient temperature with excellent selectivity, high yields, good functional group tolerance. Mechanistic studies suggest that Co(I)-catalyzed double dehydrogenative borylations generate a 1,1-diborylalkene intermediate, which undergoes hydroboration pinacolborane formed in situ to yield 1,1,1-tris(boronate).
The isomerization of olefins by complexes the pincer-ligated iridium species (tBuPCP)Ir (tBuPCP = κ3-C6H3-2,6-(CH2PtBu2)2) and (tBuPOCOP)Ir (tBuPOCOP κ3-C6H3-2,6-(OPtBu2)2) has been investigated computational experimental methods. corresponding dihydrides, (pincer)IrH2, are known to hydrogenate via initial Ir–H addition across double bond. Such an is also step in mechanism most widely proposed for olefin (the "hydride pathway"); however, results kinetics experiments DFT calculations (using...
Abstract A pyridinebis(oxazoline) cobalt complex is a very efficient precatalyst for the hydrosilylation of terminal alkynes with Ph 2 SiH , providing α‐vinylsilanes high (Markovnikov) regioselectivity and broad functional‐group tolerance. The vinylsilane products can be further converted into geminal borosilanes through Markovnikov hydroboration pinacolborane bis(imino)pyridine catalyst.
A highly selective cobalt-catalyzed single and double dehydrogenative borylations (DHBs) of terminal alkenes have been developed for the synthesis trans-monoborylalkenes diborylalkenes, respectively. While DHBs aryl 1-alkenes with 2 equiv bis(pinacolato)diboron (B2pin2) in presence 1 CsF DMF produce 1,1-diborylalkenes selectively, alkyl generate cis-1,2-diborylalkenes a manner. The 1,1-diborylalkene products are further applied to stepwise stereospecific cross-couplings halides create...