A5100377248- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Photodynamic Therapy Research Studies
- Nanoparticle-Based Drug Delivery
- Extracellular vesicles in disease
- Cancer Immunotherapy and Biomarkers
- Photoacoustic and Ultrasonic Imaging
- Immunotherapy and Immune Responses
- Graphene and Nanomaterials Applications
- Cancer Research and Treatments
- Luminescence and Fluorescent Materials
- Immune cells in cancer
- Advanced Photocatalysis Techniques
- Ultrasound and Hyperthermia Applications
- Bone Tissue Engineering Materials
- Gold and Silver Nanoparticles Synthesis and Applications
- Pancreatic and Hepatic Oncology Research
- Inflammasome and immune disorders
- Luminescence Properties of Advanced Materials
- Radiation Detection and Scintillator Technologies
- Laser Applications in Dentistry and Medicine
- interferon and immune responses
- CAR-T cell therapy research
- Hemoglobin structure and function
- Phagocytosis and Immune Regulation
Nanjing Drum Tower Hospital
2025
Nanjing Medical University
2025
Zhejiang University
2014-2025
First Affiliated Hospital Zhejiang University
2022-2025
Xuzhou Medical College
2022-2024
Guangzhou Medical University
2024
Jinzhou Medical University
2024
Shenzhen University
2014-2023
National Center for Chronic and Noncommunicable Disease Control and Prevention
2022
Zhejiang Lab
2022
Combined phototherapy and immunotherapy demonstrates strong potential in the treatment of metastatic cancers. An upconversion nanoparticle (UCNP) based antigen-capturing nanoplatform is designed to synergize phototherapies immunotherapy. In particular, this constructed via self-assembly DSPE-PEG-maleimide indocyanine green (ICG) onto UCNPs, followed by loading photosensitizer rose bengal (RB). ICG significantly enhances RB-based photodynamic therapy efficiency UCNP/ICG/RB-mal upon activation...
Abstract Immunotherapy, the most promising strategy of cancer treatment, has achieved outcomes, but its clinical efficacy in pancreatic is limited mainly due to complicated tumor immunosuppressive microenvironment. As a highly inflammatory form immunogenic cell death (ICD), pyroptosis provides great opportunity alleviate immunosuppression and promote systemic immune responses solid tumors. Herein, membrane‐targeted photosensitizer TBD‐3C with aggregation‐induced emission (AIE) feature...
BSA-bioinspired, immunoadjuvant-loaded gold nanorods for synergetic cancer photothermal therapy and immunotherapy.
Abstract Bacteria hiding in host phagocytes are difficult to kill, which can cause phagocyte disorders resulting local and systemic tissue damage. Effective accumulation of activatable photosensitizers (PSs) realize selective imaging on‐demand photodynamic ablation bacteria is great scientific practical interests for precise diagnosis treatment. Herein, HClO‐activatable theranostic nanoprobes, DTF‐FFP NPs, image‐guided bacterial introduced. NPs prepared by nanoprecipitation an...
Photoimmunotherapy has attracted much attention recently for the treatment of metastatic tumors. The development smart nanocomposites imaging-guided therapies is needed to improve efficacy cancer treatment. Herein, a PEGylated nanocomposite was developed photothermal-immunotherapy. In particular, this formulated by hybridizing Fe3O4 nanoparticles (FNPs) with reduced-graphene oxide (rGO) through electrostatic interaction, modified PEG-NH2 on surface FNPs/rGO. FNPs/rGO-PEG are excellent agents...
Radiotherapy is an important therapeutic strategy for cancer treatment through direct damage to cells and augmentation of antitumor immune responses. However, the efficacy radiotherapy limited by hypoxia-mediated radioresistance immunosuppression in tumor microenvironment. Here, we construct a stabilized theranostic nanoprobe based on quantum dots emitting near-infrared IIb (NIR-IIb, 1,500-1,700 nm) window modified catalase, arginine-glycine-aspartate peptides poly(ethylene glycol). We...
Abstract To address urgent tasks in the treatment of advanced deep‐seated tumors, a 980 nm absorbing agent with aggregation‐induced emission tendency, namely TPE‐BT‐BBTD, which simultaneously possesses longest absorption wavelength among all reported AIE molecules is developed. The functionality deep near‐infrared‐II fluorescence imaging (NIR‐II FLI) and outstanding photothermal performance well‐tailored for pancreatic cancer treatment. With covalent attachment programmed death‐ligand 1...
Dual-core@shell-structured Fe<sub>3</sub>O<sub>4</sub>–NaYF<sub>4</sub>@TiO<sub>2</sub>nanocomposites as a magnetic targeting drug carrier for bioimaging and combined chemo-sonodynamic therapy.
Photodynamic therapy (PDT) has attracted extensive attention in the clinical treatment of malignant tumor. However, acidic and hypoxic conditions tumor microenvironment (TME) limit further application PDT clinic. Herein, we fabricate a new nanoplatform─HPDA@MnO2@Ce6/DOX@PEG-RGD (HPMRCD)─by means coating hollow polydopamine nanoparticles (HPDA) with manganese dioxide (MnO2), which is modified by cyclic RGD functionalized poly(ethylene glycol) (PEG) co-loaded photosensitizer, Chlorin e6 (Ce6),...
Abstract Antimony (Sb), a typical group VA semimetal, has rarely been studied both experimentally and theoretically in plasmonic photothermal therapy, possibly due to the lack of effective morphology‐controllable methods for preparation high‐quality Sb nanocrystals. In this study, an ligand‐guided growth strategy controllably synthesize nanopolyhedrons (Sb NPHs) with ultrahigh conversion efficiency (PTCE), good stability, as well biocompatibility is presented. Furthermore, modulation effect...
Abstract Currently, radiotherapy (RT) is the main method for cancer treatment. However, hypoxic environment of solid tumors likely to cause resistance or failure RT. Moreover, high‐dose radiation may side effects surrounding normal tissues. In this study, a new type nanozyme developed by doping Mn (II) ions into Ag 2 Se quantum dots (QDs) emitting in second near‐infrared window (NIR‐II, 1000–1700 nm). Through catalysis ions, nanozymes can trigger rapid decomposition H O and produce ....
Abstract Post‐surgical tumor recurrence remains a major clinical concern for patients with malignant solid tumors. Herein, an immunotherapeutic hydrogel (SA PBA /ZMC/ICG) is developed by incorporating metal ion‐cyclic dinucleotide (CDN) nanoparticles (Zn‐Mn‐CDN, ZMC) and photosensitizer (indocyanine green, ICG) into phenylboronic acid (PBA)‐conjugated sodium alginate ) photothermal therapy (PTT)‐triggered in situ vaccination to inhibit post‐surgical metastasis of The gelation SA /ZMC/ICG the...
Sonodynamic Therapy (SDT) has good targeting and non-invasive advantages in solid cancers, but its antitumor effect is not sufficient to replace traditional treatments. Some studies that combined SDT with chemotherapy or nanoparticles have managed enhance efficiency overcome the side effects of chemotherapy.In this study, we synthesized characterized mesoporous silica (MSN-DOX-Ce6) loaded doxorubicin (DOX) sonosensitizer, chlorin e6 (Ce6). Then, conducted vitro vivo experiments explore...
Energy transfer upconversion (ETU) can efficiently upconvert near-infrared photons into higher-energy photons. Although a comprehensive understanding of ETU is fundamental to the design materials, basic excited-state decay kinetics remains complicated problem. Here we unravel mechanism underlying in benchmark β-NaYF4:Er3+ and β-NaYF4:Ln3+/Yb3+ (Ln = Er, Ho, Tm) microcrystals by combining rate equation analyses with measurements. The results show that all excited states one system...
Abstract Metallic and semimetallic mesoporous frameworks are of great importance owing to their unique properties broad applications. However, structures cannot be obtained by the traditional template-mediated strategies due inevitable hydrolytic reaction semimetal compounds. Therefore, it is yet challenging fabricate nanostructures, not even mention controlling pore sizes. Here we develop a facile robust selective etching route synthesize monodispersed antimony nanospheres (MSbNSs). The...
The therapeutic effect of chemotherapeutics such as gemcitabine against pancreatic cancer is considerably attenuated by immune-suppressive tumor microenvironment. Improvement chemotherapeutic efficacy targeting tumor-associated macrophage and reprograming microenvironment to enhance their may become a promising strategy. To this end, we developed biomimetic dual-targeting nanomedicine (PG@KMCM) where gemcitabine-loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles are coated with layer...
Currently, radical gastrectomy for gastric cancer is usually combined with lymph node tracing technology to ensure the complete removal of metastatic nodes. Our case demonstrates that bismuth compounds may be useful as tracers in gastrectomy. A 37-year-old man who was confirmed diagnosis found have black-stained nodes during surgical resection. The patient's medication history, pathological analysis and Inductively coupled plasma mass spectrometry (ICP-MS) presence dark particle deposited...