Abstract The malignancy of colorectal cancer (CRC) is connected with inflammation and tumor-associated macrophages (TAMs), but effective therapeutics for CRC are limited. To integrate therapeutic targeting tumor microenvironment (TME) reprogramming, here we develop biocompatible, non-covalent channel-type nanoparticles (CNPs) that fabricated through host-guest complexation self-assemble mannose-modified γ-cyclodextrin (M-γ-CD) Regorafenib (RG), RG@M-γ-CD CNPs. In addition to its carrier...

Abstract Bacteria hiding in host phagocytes are difficult to kill, which can cause phagocyte disorders resulting local and systemic tissue damage. Effective accumulation of activatable photosensitizers (PSs) realize selective imaging on‐demand photodynamic ablation bacteria is great scientific practical interests for precise diagnosis treatment. Herein, HClO‐activatable theranostic nanoprobes, DTF‐FFP NPs, image‐guided bacterial introduced. NPs prepared by nanoprecipitation an...

A living therapeutic system based on attenuated <italic>Salmonella</italic> was developed <italic>via</italic> metabolic engineering using an aggregation-induced emission (AIE) photosensitizer <bold>MA</bold>.

Summary Mango is a nutritious fruit but susceptible to the development of black spots on its skin, which can significantly reduce post‐harvest quality. In response this challenge, study focused preparing and characterising two inclusion complexes (ICs) by combining cinnamon essential oil (CEO) lemongrass (LEO) with β‐cyclodextrin (β‐CD), named CEO‐β‐CD LEO‐β‐CD. Their effectiveness in preserving mango were evaluated. The findings demonstrated successful encapsulation oils β‐CD, forming...

Abstract BACKGROUND Papaya, a highly nutritious and economically significant fruit, is susceptible to infections caused by phytopathogenic fungi. Cinnamon essential oil, derived from Cinnamomum cassia (CC), shows promise in preserving papaya due its antifungal properties. However, CC volatile, sensitive environmental factors, carries strong aroma. γ ‐Cyclodextrin ( ‐CD) known for encapsulating hydrophilic molecules, shielding them influences, reducing odor, enabling controlled release unique...

The dissolution rate is the rate-limiting step for Biopharmaceutics Classification System (BCS) class II drugs to enhance their in vivo pharmacokinetic behaviors. There are some factors affecting rate, such as polymorphism, particle size, and crystal habit. In this study, improve pharmacokinetics of sorafenib tosylate (Sor-Tos), a BCS drug, two habits Sor-Tos were prepared. A plate-shaped habit (ST-A) needle-shaped (ST-B) harvested by recrystallization from acetone (ACN) n-butanol (BuOH),...

Two new co-crystals, Ticagrelor with Nicotinamide, have been prepared improved solubility. Because Ticalegor has a poor solubility and dissolution rate, novel co-crystallization method structurally homogenous crystalline material, an active pharmaceutical ingredient (API), co-former indefinite stoichiometric amount made to improve Ticagrelor’s The co-crystal of (TICA) Nicotinamide (NCA) was in ratio (1:1) confirmed by FTIR, DSC, XRD characterization. Furthermore, the single crystal structure...

Drugs with poor biopharmaceutical performance are the main obstacle to development and design of medicinal preparations. The anisotropic surface chemistry different surfaces on crystal influences its physical chemical properties, such as solubility, tableting, etc. In this study, antisolvent crystallization rapid-cooling were carried out tune habits ticagrelor (TICA) form II. Different II (TICA-A, TICA-B, TICA-C, TICA-D, TICA-E) prepared evaluated for solubility. single-crystal diffraction...

Puerarin (PUE) is a Chinese traditional medicine known to enhance glucose uptake into the insulin cells downregulate blood levels in treatment of type II diabetes. Nevertheless, bioavailability pristine PUE limited due its poor solubility and low intestinal permeability. In this work, we demonstrate that can be significantly enhanced via co-crystallization with L-Proline (PRO). Two crystalline phases, namely, solvate-free form [PUE][PRO] (I) solvated [PUE]2[PRO]∙EtOH∙(H2O)2 (II) are...

Hepatocellular carcinoma (HCC) is a hypervascular tumour characterized by tumour-driven neovascularization. The degrees of blood oxygen saturation (DBOS), microvessel density (MVD) and size (TS) are indicators in identifying the development stage HCC. Herein, we proposed an HCC staging model using HepG2 tumour-bearing mice based on DBOS, MVD TS. According to patterns these three criteria, was classified into four stages: early, intermediate, advanced end stages. 50-90 (number per mm2), DBOS...

Abstract Drug solubility plays a significant role in the development of drug formulation. The objectives this work are to improve and dissolution rate vortioxetine (VT) by preparing its inclusion complexes (ICs) with β‐Cyclodextrin (β‐CD) γ‐Cyclodextrin (γ‐CD). ICs were prepared 1:1 M ratio via recrystallization method characterized P‐XRD, FT‐IR, 1 H NMR, 2D NOESY, DSC. Further, crystal structure VT‐β‐CD was analyzed SC‐XRD. P‐XRD data obtained for describe crystalline pattern. DSC analysis...

Abstract Studies on neutrophil‐based nanotherapeutic engineering have shown great potentials in treating infection and inflammation disorders. Conventional neutrophil labeling methods are time‐consuming often result undesired contamination activation since neutrophils terminal‐differentiated cells with a half‐life span of only 7 h. A simple, fast, biocompatible strategy to construct engineered is highly desirable but remains difficult achieve. In this study, we present an AIEgen‐lipid...

Sorafenib and regorafenib (or fluoro-sorafenib) are multikinase inhibitors active in the treatment of various human cancers, but their solubilities very poor. To improve solubilities, this study, sorafenib hydrochloride (Sor·HCl, I) (Reg·HCl, II) have been prepared crystal structures were characterized. Their solubility properties water evaluated. Intriguingly, they isomorphous with same space group similar unit cell dimensions, which caused by supramolecular patterns resulted formation...

Sorafenib (Sor) is an oral multi-kinase inhibitor, but its water solubility very low. To improve solubility, sorafenib hydrochloride hydrate, hydrobromide and hydrate were prepared in the mixed solvent of corresponding acid solution, tetrahydrofuran (THF). The crystal structures trihydrate (Sor·HCl.3H2O), 4-(4-{3-[4-chloro-3-(trifluoro-methyl)phenyl]ureido}phenoxy)-2-(N-methylcarbamoyl) pyridinium trihydrate, C21H17ClF3N4O3+·Cl−.3H2O (I), monohydrate (Sor·HCl.H2O), C21H17ClF3N4O3+·Cl−.H2O...

Abstract Studies on neutrophil‐based nanotherapeutic engineering have shown great potentials in treating infection and inflammation disorders. Conventional neutrophil labeling methods are time‐consuming often result undesired contamination activation since neutrophils terminal‐differentiated cells with a half‐life span of only 7 h. A simple, fast, biocompatible strategy to construct engineered is highly desirable but remains difficult achieve. In this study, we present an AIEgen‐lipid...

Sorafenib is an oral multi-target kinase inhibitor that has been used to treat unresectable hepatocellular carcinoma and advanced renal cell carcinoma. The aim of the study was prepare gum Arabic-chitosan (GA-CS) Arabic-modified chitosan (GA-MCS) microcapsules containing sorafenib as core phase by complex coacervation. fluorescence microscopy, dynamic light scattering (DLS), drug loading, encapsulation efficiency were clarified. GA-MCS microcapsule successfully performed at approximate pH 4...

Novel bio-inspired nanoarchitectured materials with surface functionalized properties have potential applications in various fields. Polymeric porous nanomaterials/particles/capsules are taking as a challenging task for porosity payload anticancer drugs and nanomedicines drug delivery cancer theranostics. The block copolymer of [(PLGA)-b-(PNIPAM)] is along biodegradable, biocompatible bio-safe (3B) polymers these can help to design develop carrier nanomaterial biomedical biotechnological...

Salt formation is the most commonly method for increasing solubility of drug. Sorafenib (Sor), a multikinase inhibitor active in treatment board human cancers, has very low solubility. In this study, sorafenib sulfate monohydrate (Sor-S) been prepared improving its The simulated powder X-ray diffraction (PXRD) was different from experimental PXRD free Sor. crystal structure Sor-S characterized. hydrogen bond system, topology, and superposition molecular conformations base form protonated...