A5084428415- Galectins and Cancer Biology
- Aortic Disease and Treatment Approaches
- Aortic aneurysm repair treatments
- Estrogen and related hormone effects
- Heme Oxygenase-1 and Carbon Monoxide
- Cardiac Imaging and Diagnostics
- Cellular transport and secretion
- Drug Transport and Resistance Mechanisms
- Atrial Fibrillation Management and Outcomes
- Hepatitis C virus research
- Infective Endocarditis Diagnosis and Management
- Retinoids in leukemia and cellular processes
- Phagocytosis and Immune Regulation
- Liver Disease Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Liver physiology and pathology
Sun Yat-sen University
2025
First Hospital of Lanzhou University
2024
Lanzhou University
2024
First Affiliated Hospital of Xi'an Jiaotong University
2022-2023
Beijing Proteome Research Center
2012
Abstract Cancer cells present sialylated glycoconjugates that modulate the activity of various immune within tumor microenvironment through trans interaction with immunosuppressive Siglec receptors. Identifying counter receptors for Siglecs can provide valuable targets cancer immunotherapy, but it presents significant challenges. Here, identification DSG2 (Desmoglein 2) as a dominant receptor Siglec‐9 in melanoma is reported, using workflow combines strength proximity labeling and advantage...
Liver fibrosis can progress to cirrhosis and hepatocellular carcinoma. Currently, there is no effective drug for liver fibrosis. The peptide 6 (T6) an endogenous derived from human intrauterine adhesion tissues has antifibrotic potential. Here, improve the long-term efficacy activity of T6, we conducted rational modified T6 through studying structure–activity, synthesized a series analogues. Among them, S6 S6-FA exhibited optimal antihepatic activity, had stronger long-acting effect than S6....
Nuclear receptors (NRs) are a superfamily of transcription factors that, upon binding to ligands, bind specific DNA sequences and regulate transcriptional program governing cell proliferation, differentiation, metabolism. In the liver, by sensing lipid-soluble hormones dietary lipids expression key liver metabolic genes, NR proteins direct large array hepatic functions that include lipid glucose metabolism, bile secretion, acid homeostasis. Although much has been learned about physiology...
Serum total bilirubin (STB) is recently more regarded as an antioxidant with vascular protective effects. However, we noticed that elevated STB appeared in unstable angina pectoris (UAP) patients diffused coronary lesions. We aimed to explore STB's roles UAP patients, which have not been reported by articles. 1120 were retrospectively screened, and 296 finally enrolled. They grouped Canadian Cardiovascular Society (CCS) grades. The synergy between PCI TAXUS stent cardiac surgery score...
Aim: The current study was performed to define the role of KDM3A in thoracic aortic dissection (TAD). Methods: binding HIF1α and HES1 detected by ChIP dual-luciferase reporter gene assay. Loss gain-of function assays HIF1α, were further Ang-II-induced mouse smooth muscle cell line (MOVAS) cells. Lastly, vivo TAD models established. Results: highly expressed TAD. promoted transcription activation HES1. enhanced proliferation migration MOVAS cells, addition increasing aorta dilation induce...