A5100419098- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Spectroscopy and Chemometric Analyses
- DNA Repair Mechanisms
- Breast Cancer Treatment Studies
- Melanoma and MAPK Pathways
- Spectroscopy Techniques in Biomedical and Chemical Research
- Peroxisome Proliferator-Activated Receptors
- Amino Acid Enzymes and Metabolism
- Mitochondrial Function and Pathology
- Immune cells in cancer
- RNA Research and Splicing
- Metabolomics and Mass Spectrometry Studies
- Esophageal Cancer Research and Treatment
- Fibroblast Growth Factor Research
- Global Cancer Incidence and Screening
- Inflammatory mediators and NSAID effects
- CRISPR and Genetic Engineering
- Glycosylation and Glycoproteins Research
- PI3K/AKT/mTOR signaling in cancer
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
State Key Laboratory of Oncology in South China
2016-2025
Sun Yat-sen University
2016-2025
Sun Yat-sen University Cancer Center
2016-2025
First Affiliated Hospital of Gannan Medical University
2025
Qingdao University
2022-2025
Affiliated Hospital of Qingdao University
2022-2025
Taihe Hospital
2024
Zhejiang University
2012-2024
Gannan Medical University
2024
Jinan University
2021-2024
Abstract Background Statistical data on the incidence, mortality, and burden of breast cancer relevant risk factors are valuable for policy-making. We aimed to estimate deaths, disability-adjusted life years (DALYs) by country, gender, age group, social-demographic status between 1990 2017. Methods extracted from 2017 Global Burden Disease (GBD) study through in 195 countries territories. Data about number incident cases, DALYs, age-standardized rates were collected. also estimated...
Treatment of BRAFV600E -mutant melanomas with MAPK inhibitors (MAPKi) results in significant tumor regression, but acquired resistance is pervasive. To understand nonmutational mechanisms underlying the adaptation to MAPKi and identify novel vulnerabilities treated MAPKi, we focused on initial response phase during treatment MAPKi.By screening proteins expressed cell surface melanoma cells, identified fatty acid transporter CD36 as most consistently upregulated protein upon short-term MAPKi....
Abstract Introduction It remains unclear whether marital status could affect the breast cancer‐caused special survival (BCSS) of patients with cancer. Therefore, we sought to explore influence demographic and pathological factors on prognosis Materials methods We selected meeting eligibility criteria from Surveillance, Epidemiology, End Results (SEER) cancer registry program. assessed effect overall (OS) BCSS using Kaplan‐Meier curve multivariate Cox proportional hazards regression. Compared...
Cancer cells undergo metabolic reprogramming to adapt high oxidative stress, but little is known about how remodeling enables gastric cancer survive stress associated with aberrant reactive oxygen species (ROS) production. Here, we aimed identify the key enzymes that protect (GC) from stress.
Lead (Pb) is a widely spread pollutant and leads to diverse morphological structural changes in the plants. In this study, alleviating role of 5-aminolevulinic acid (ALA) oilseed rape ( Brassica napus L.) was investigated with or without foliar application ALA (25 mg L −1 ) hydroponic environment under different Pb levels (0, 100, 400 µM). Outcomes stated that plant morphology photosynthetic attributes were reduced alone. However, significantly increased growth parameters toxicity. Moreover,...
SOD1 is an abundant enzyme that has been studied as a regulator of the antioxidant defence system, and this well known for catalyzing dismutation superoxide into hydrogen peroxide. However in progress NPC underlying mechanisms remain unclear. In tissue samples, protein levels were measured by Western blot immunohistochemical (IHC) staining. mRNA activity monitored qRT-PCR SOD kit, respectively. Kaplan-Meier survival analysis was performed to explore relationship between expression prognosis...
Gene expression profiling is an effective method for identifying predictive and prognostic biomarkers. However, measurements are prone to uncertainty errors due various pre-analytical variables. Systematic evaluating effects of these variables on gene relative orderings (REOs) pairs, necessary. A total 18 datasets were collected, comprising over 800 paired samples. These samples utilized assess the impact REOs, including sampling methods, tumor sample heterogeneity, fixed time delays,...
ABSTRACT Aberrant iron metabolism is frequently observed in cancers, including endometrial cancer (EC). However, the role of transferrin receptor (TFRC), a key regulator metabolism, remains unclear cancer. We found expression was significantly upregulated tissues compared to adjacent nontumor tissues, and high levels were associated with poor prognosis. Functional studies revealed that knockdown impaired cell proliferation vitro vivo, while overexpression enhanced proliferation....
// Zhi-Jian Zou 1,2 , Lei Fan 1 Li Wang Ji Xu Run Zhang Tian Jian-Yong and Wei Department of Hematology, the First Affiliated Hospital Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China 2 Wuxi People Wuxi, Correspondence: Xu, email: Keywords : chronic lymphocytic leukemia; PTEN; mutation; microRNA Received July 28, 2014 Accepted October 23, Published 24, Abstract We previous found expression level PTEN was low in leukemia (CLL) patients. To assess pathogenic contribution...
Significance A timely and appropriate response to genotoxic stress is essential for maintaining genome stability preventing tumorigenesis. Here, we have established a previously unidentified role of the protein kinase ATM in controlling extent DNA end resection during homology-directed repair. Specifically, elicits sequential posttranslational modifications key factor CtIP thereby fine-tunes its activity at DSB sites. Our findings highlight multistep roles master orchestrating damage responses.
A series of 3,4-disubstituted piperidine derivatives were obtained based on a conformational restriction strategy and lead compound, A12, that exhibited potent in vitro vivo antitumor efficacies; however, obvious safety issues limited its further development. Thus, systematic exploration the structure–activity relationship compound involving phenyl group, hinge-linkage, moiety, led to discovery superior 3,4,6-trisubstituted derivative E22. E22 showed increased potency Akt1 cancer cell...
The solubilities of cholesterol in methanol, anisole, acetic acid, ethyl acetate, heptane, methyl isobutyl ketone (MIBK), and mixed solvent (ethanol–MIBK) are determined the temperature range 283.2 to 318.2 K. experimental pure solvents binary found increase with increasing temperature. In (ethanol–MIBK), mass fraction ethanol first then decrease. maximum solubility can be obtained when is approximately 10%. MIBK, anisole larger than those acid. correlated van′t Hoff, modified Apelblat,...
Objective: The current study aimed to explore the function of miR-638 on progression oral squamous cell carcinoma (OSCC) and relevant molecular mechanisms.Methods: Expression profile in OSCC tissues cells was detected using quantitative real-time polymerase chain reaction (qRT-PCR) method. Chi-square test performed estimate relationship between clinical parameters cases. Cell viability motility abilities were estimated MTT transwell assays, respectively. Potential targets identified through...
Visible and near infrared (Vis/NIR) spectroscopy was investigated for the fast analysis of superoxide dismutase (SOD) activity in barley (Hordeum vulgare L.) leaves. Seven different spectra preprocessing methods were compared. Four regression used comparison prediction performance, including partial least squares (PLS), multiple linear (MLR), squares-support vector machine (LS-SVM) Gaussian process regress (GPR). Successive projections algorithm (SPA) coefficients (RC) applied to select...