Abstract Breast cancer (BC) is a multifaceted disease characterized by distinct molecular subtypes and varying responses to treatment. In BC, the phosphatidylinositol 3-kinase (PI3K) pathway has emerged as crucial contributor development, advancement, resistance This review article explores implications of PI3K in predictive, preventive, personalized medicine for BC. It emphasizes identification predictive biomarkers, such PIK3CA mutations, utility profiling guiding treatment decisions. The...

This review explores the hallmarks of cancer resistance, including drug efflux mediated by ATP-binding cassette (ABC) transporters, metabolic reprogramming characterized Warburg effect, and dynamic interplay between cells mitochondria. The role stem (CSCs) in treatment resistance regulatory influence non-coding RNAs, such as long RNAs (lncRNAs), microRNAs (miRNAs), circular (circRNAs), are studied. chapter emphasizes future directions, encompassing advancements immunotherapy, strategies to...

Abstract Oral squamous cell carcinoma (OSCC) in the background of oral submucous fibrosis (OSF) caused by areca nut chewing has a high incidence Asia-Pacific countries. However, molecular mechanism remains unclear. Here, we performed circRNA microarray analysis to screen expression profiles OSCC and OSF. We identified circEPSTI1 as with consistent, sequential upregulation from normal buccal mucosa (NBM) OSF OSCC. Functionally, significantly promoted proliferation invasion, evidenced CCK8,...

Abstract Objective This study developed an AI-powered chatbot simulating a patient with acute pulpitis to enhance history-taking training in stomatology, aiming at providing cost-effective tool that improves diagnostic and communication skills while fostering clinical competence empathy. Methods The involved 126 undergraduate medicine students who interacted AI agent suffering pulpitis. was created optimized five-step process, including preliminary creation, usability testing Chatbot...

Introduction Senecavirus A (SVA), an emerging vesicular pathogen, is responsible for porcine idiopathic disease (PIVD). This closely associated with and acute neonatal piglet mortality, presenting a substantial threat to the global swine industry. At present, absence of effective drugs or vaccines treating makes accurate diagnosis SVA paramount importance prevention control disease. Methods In this study, we combined reverse transcription loop-mediated isothermal amplification (RT-LAMP)...

Cellular tropism of vaccinia virus (VACV) is regulated by host range genes, including K1L, C7L, and E3L. While E3L known to support viral replication antagonizing interferon (IFN) effectors, PKR, the exact functions K1L C7L are unclear. Here, we show that can also inhibit antiviral effectors induced type I IFN. In human Huh7 MCF-7 cells, a VACV mutant lacking both (vK1L-C7L-) replicated as efficiently wild-type (WT) VACV, even in presence However, pretreating cells with IFN, while having...

To explore the pathogenesis of oral submucosal fibrosis (OSF) by analyzing impact Platelet Derived Growth Factor (PDGF)-BB on mucosal fibroblasts (FB) and PDGFR-β/Phosphoinositide 3-kinase (PI3K)/serine/threonine protein kinase (AKT) signaling pathway.The isolated purified were divided into four groups: control group (CON, 10% FBS DMEM), PDGF-BB (40 ng/ml PDGF-BB), PDGF-BB+IMA 60 μmol/L IMA), PDGF-BB+LY294002 48 LY294002). Primary human FB cells cultured for detecting effects α-smooth muscle...

The anterolateral thigh flap has been the workhouse for coverage of soft-tissue defects in head and neck decades. However, reconstruction multiple complex with multipaddled chimeric flaps is still a challenge reconstructive surgeries. Here, clinical series 12 cases reported which were used several separately anatomic locations neck. Of cases, 7 patients presented trismus diagnosed as advanced buccal cancer oral submucous fibrosis, 2 tongue found accompanied mucosa lesions or cancer, 3...

Recent studies have shown that substance dependence (addiction) is accompanied with altered activity patterns of the default mode network (DMN). However, neural correlates resting-state DMN and betel quid (BQD)-related physiopathological characteristics still remain unclear. Resting-state functional magnetic resonance imaging images were obtained from 26 BQD individuals 28 matched healthy control subjects. Group independent component analysis was performed to analyze resting state into...

Objectives The study aimed to investigate the ceRNA network in biological development of Tongue Squamous Cell Carcinoma (TSCC) and identify novel molecular subtypes TSCC screen potential biomarkers for target therapy prognosis by using integrated genomic analysis based on Cancer Genome Atlas (TCGA) database. Material methods Data gene expressions were downloaded from TCGA GEO Differentially expressed RNAs(DERNAs) shown DESeq2 package R. Functional enrichment DEmRNAs was performed...

Computer-assisted and template-guided mandibular reconstruction provides higher accuracy less variation than conventional freehand surgeries. The combined osteotomy pre-shaped plate position (CORPPP) technique is a reliable choice for reconstruction. This study aimed to evaluate the of CORPPP-guided fibular flap analyze possible causes deviations.From June 2015 December 2016, 28 patients underwent Virtual planning personalized templates were applied in 15 while 13 received Deviations during...

The abnormal proliferation and differentiation of oral mucosal fibroblasts (FBs) is the key to progression submucosal fibrosis. To clarify mechanism platelet-derived growth factor (PDGF-BB)-induced FBs fibrosis in mucosa, real-time quantitative polymerase chain reaction Western blot were used this study detect expression miR-503 p-MEK, p-ERK, miR-503, RAF, smooth actin type I collagen under different time concentration stimulation PDGF-BB. effects overexpression or RAF on migration detected...

The study was designed to investigate immunocompetence in relation cancer progression rat and assess the effect of traditional Chinese anti-cancer medicine, "Shenyang" prescription, on immunity.4-Nitroquinoline-1-oxide (4NQO) administered 80 Sprague-Dawley (SD) rats via drinking water for up 36 weeks. Tongue squamous cell carcinoma (SCC) confirmed by pathological examination 61 rats. prescription subgroups these rats, blood samples were taken before after treatment. Lymphocyte subsets...

To introduce and evaluate the clinical effects of digital surgical guide plate technology in combined osteotomy reconstruction pre-bent position (CORPPP) technique during mandibular segmental resections.Seven cases resection with simultaneous vascularized free fibula flap by oral maxillofacial surgery were selected (Xiangya Hospital, Changsha, China; June 2015 through December 2015). Cone-beam computed tomographic (CBCT) spiral CT scans mandibles fibular donor sites, respectively, collected....

In South and Southeast Asian, the majority of buccal squamous cell carcinoma (BSCC) can arise from oral submucous fibrosis (OSF). BSCCs develop in OSF that are often not completely resected, causing local relapse. The aim our study was to find candidate protein biomarkers detect predict prognosis by quantitative proteomics approaches. We compared normal mucosa (NBM) paired biopsies BSCC using isobaric tags for relative absolute quantification (iTRAQ) discover proteins with differential...