A5023118686- Reconstructive Surgery and Microvascular Techniques
- Head and Neck Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Reconstructive Facial Surgery Techniques
- Cleft Lip and Palate Research
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Atrial Fibrillation Management and Outcomes
- Nutrition and Health in Aging
- Bladder and Urothelial Cancer Treatments
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Neuroblastoma Research and Treatments
- Pancreatitis Pathology and Treatment
- Liver Disease Diagnosis and Treatment
- Cardiac Arrhythmias and Treatments
- Pregnancy and preeclampsia studies
- Cancer Research and Treatments
- Oral Health Pathology and Treatment
- Gallbladder and Bile Duct Disorders
Fujian Medical University
2016-2025
Xiangya Hospital Central South University
2017-2025
Central South University
2014-2025
Fujian Provincial Hospital
2016-2025
Fuzhou University
2024
Foshan University
2023
Chengdu University
2023
Zhuhai People's Hospital
2023
Jinan University
2023
Wannan Medical College
2022
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a devastating cancer with dismal prognosis due to distant metastasis, even in the early stage. Using RNA sequencing and multiplex immunofluorescence, here we find elevated expression of mixed lineage kinase domain-like pseudo-kinase (MLKL) enhanced necroptosis pathway PDAC from liver metastasis T-stage (T1M1) patients comparing non-metastatic (T1M0) patients. Mechanistically, MLKL-driven recruits macrophages, enhances tumor CD47 ‘don’t eat...
Abstract Background Pancreatic neuroendocrine tumors (PNETs) are one of the most common endocrine tumors, and liver metastasis (LMs) location from PNETS; However, there is no valid nomogram to predict diagnosis prognosis PNETs. Therefore, we aimed develop a predictive model aid physicians in making better clinical decisions. Methods We screened patients Surveillance, Epidemiology, End Results (SEER) database 2010–2016. Feature selection was performed by machine learning algorithms then...
Intrahepatic cholangiocarcinoma (ICC) is characterized by its dense fibrotic microenvironment and highly malignant nature, which are associated with chemotherapy resistance very poor prognosis. Although circRNAs have emerged as important regulators in cancer biology, their role ICC remains largely unclear. Herein, a circular RNA, cPKM identified, upregulated Silencing cells reduces TGFB1 release stromal fibrosis, inhibits STMN1 expression, suppresses growth metastasis, moreover, it also...
The specific impacts of sarcopenic obesity (SO) on hepatocellular carcinoma (HCC) and the association between SO systemic inflammation remain unclear. This study aimed to investigate prognostic value with outcomes after hepatectomy for HCC develop novel nomograms based inflammatory indexes survival prediction.We retrospectively enrolled 452 patients who underwent radical January 2012 March 2015 in Fujian Provincial Hospital as training cohort. In addition, 275 during same period were...
Small cell cervical carcinoma (SCCC) is a rare, aggressive tumor with poor prognosis. However, information in relation to its treatment scarce due the limited numbers of patients. The aim this study was establish whether platinum-based combination chemotherapy may by beneficial patient population. We carried out multicenter, retrospective comprising 72 Chinese patients SCCC. were treated between 1995 and 2010 at Sun Yat-sen Memorial Hospital or Cancer Center Yat-Sen University, First...
Cerebrocardiac syndrome (CCS) is a severe complication of traumatic brain injury (sTBI) that carries high mortality and disability rates. Early identification CCS poses significant clinical challenge. The main objective this study was to investigate potential risk factors associated with the development secondary in patients sTBI. It hypothesized elevated right heart Tei index (TI), lower Glasgow Coma Scale (GCS) scores, cardiac troponin-I (cTnI) levels would independently contribute...
Hydrogen (H2) gas is recognized for its anti-oxidative, anti-apoptotic, and anti-inflammatory properties in multiple plant animal models. Nevertheless, there a lack of research on the effects H2 administration fish. This seeks to investigate how affects growth performance, mammalian target rapamycin (mTOR) nuclear factor erythroid 2-related 2 (Nrf2) signaling pathways, intestinal microbiota juvenile largemouth bass under normal feeding conditions. The randomly allocated 240 fish (3.55 ± 0.01...
Accumulating evidence suggests that β‑catenin signaling may be involved in oral tongue squamous cell carcinoma (OTSCC) invasion. Abnormal activation of twist‑related protein 1 (TWIST1 or TWIST) has been identified several types human cancer. A recent study showed overexpression TWIST is associated with a poor prognosis patients OTSCC and enhance This investigated the effect on cells its impact OSTCC Stable TWIST, without knockdown β‑catenin, stable were performed SCC‑4 TCA8113 cells....
The emergence of carbapenem-resistant Klebsiella pneumoniae (CRKP) strains has led to increased mortality and morbidity rates. Tigecycline, a new class broad-spectrum glycyl-tetracycline antibiotics, been used target multi- pan-drug-resistant bacterial infections. This study aimed assess the molecular characteristics CRKP in tertiary hospital, its susceptibility tigecycline, create reference for hospital infection control clinical drug use.We retrieved patient information characterization...
Propensity score-matched analyses comparing the safety and efficacy of laparoscopic pancreaticoduodenectomy (LPD) to open (OPD) that consider effect learning curve for LPD are lacking. We use compare during OPD.The medical records 296 consecutive patients who had undergone or OPD between September 2016 August 2019 at Fujian Provincial Hospital were retrospectively reviewed. Patients treated with matched 1:1 those OPD. Calculation propensity scores considered age, gender, body mass index...