A5065573406- Prostate Cancer Treatment and Research
- Cancer, Hypoxia, and Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Glycosylation and Glycoproteins Research
- Prostate Cancer Diagnosis and Treatment
- Protein purification and stability
- RNA modifications and cancer
- Urologic and reproductive health conditions
- Complement system in diseases
- Cancer-related molecular mechanisms research
- Blood properties and coagulation
- Metabolomics and Mass Spectrometry Studies
- Reconstructive Surgery and Microvascular Techniques
- Protease and Inhibitor Mechanisms
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Urological Disorders and Treatments
- Physical Activity and Health
- Brain Metastases and Treatment
- Circular RNAs in diseases
- High Altitude and Hypoxia
- Reconstructive Facial Surgery Techniques
- Biomarkers in Disease Mechanisms
- Mass Spectrometry Techniques and Applications
University College London
2021-2025
Institute of Structural and Molecular Biology
2021-2025
Qilu Hospital of Shandong University
2019-2024
Beijing Sport University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
University College Lahore
2023
Minzu University of China
2023
First Hospital of Jilin University
2023
Jilin University
2023
State Ethnic Affairs Commission
2023
Lipids represent the essential components of membranes, serve as fuels for high-energy processes, and play crucial roles in signaling cellular function. One key hallmarks cancer is reprogramming metabolic pathways, especially abnormal lipid metabolism. Alterations uptake, desaturation, de novo lipogenesis, droplets, fatty acid oxidation cells all contribute to cell survival a changing microenvironment by regulating feedforward oncogenic signals, functions, oxidative other stresses, immune...
Lysine lactylation (Kla) plays a vital role in several physiological processes. However, the cancer-specific modulation of Kla gastrointestinal (GI) tumors requires systematic elucidation. Here, global lactylome profiling cancerous and adjacent tissues is conducted from 40 patients with GI cancer identified 11698 sites. Lactylome integration revealed that affects proteins involved hallmark processes, including epigenetic rewiring, metabolic perturbations, genome instability. Moreover, study...
Beta-2-Glycoprotein I (β2GPI) is the main autoantigenic target of antiphospholipid syndrome (APS) with antibodies leading to clinical manifestations. There are two known structural isomers β2GPI, a J shape and circular shaped one. The transition between these structures incompletely understood, functional implications unknown. β2GPI substrate protease plasmin, which cleaves within fifth domain altered cellular binding. Very little currently regarding structure function this protein variant....
Interleukin-33 (IL-33), belonging to IL-1 family cytokines, has been reported participate in cancer growth and metastasis. The clinical values of IL-33 lung have previously investigated. We aimed elucidate the probable role migration invasion cells.Cell invasiveness were tested by Transwell assay. Western blotting analysis was performed detect protein expression.We found that treatment human A549 cells dose-dependently enhanced their migratory invasive ability, accompanied elevated...
The goal of our study was to screen tumor grade-related lncRNAs and mRNAs reveal the underlying molecular mechanism esophagus squamous cell carcinoma (ESCC).The lncRNA mRNA sequencing data were obtained from Cancer Genome Atlas (TCGA). Tumor grade correlation analysis executed, followed by functional enrichment all mRNAs. differentially expression (DEmRNAs) expressed (DElncRNAs) obtained. PPI network DEmRNA-DElncRNA interaction constructed. annotation DEmRNAs co-expressed with DElncRNAs...
Background c-Myc , EZH2 and p27 were defined to modulate the behavior of prostate cancer with pro-tumoral or anti-tumoral effects had ability in predicting progression, but research their co-expression value prognosis is rarely. This study aimed investigate prognostic combining tri-marker together patients intermediate-risk after surgery. Methods Expression levels 129 assessed using immunohistochemistry a semi-quantitative manner. The expression profiles these three markers analyzed...
Understanding the renal region-specific metabolic alteration in different animal models of diabetic nephropathy (DN) is critical for uncovering underlying mechanisms and developing effective treatments. In present study, spatially resolved metabolomics based on air flow-assisted desorption electrospray ionization mass spectrometry imaging (AFADESI-MSI) was used to compare local changes kidneys HFD/STZ-induced rats db/db mice. As a result, total 67 59 discriminating metabolites were...
As an important place of material exchange, the homeostasis pulmonary circulation environment and function lays essential foundation for normal execution various physiological functions body. Small metabolic molecules in can reflect corresponding state circulation.We enrolled patients with Patent Foramen Ovale obtained blood from arteries veins through heart catheterization. UPLC-MS based untargeted metabolomics was used to compare changes differences plasma between vein artery.The revealed...
FcγRI (CD64) is the only high-affinity Fcγ receptor found on monocytes, macrophages, eosinophils, neutrophils and dendritic cells. It binds immunoglobulin G (IgG) antibody-antigen complexes at its Fc region to trigger key immune responses. CD64 contains three immunoglobulin-fold extracellular domains (D1, D2 D3) a membrane-spanning region. Despite importance of CD64, no solution structure for this known date. To investigate this, we used analytical ultracentrifugation, small-angle X-ray...
Antibody-fragment (Fab) therapy development has the potential to be accelerated by computational modelling and simulations that predict their target binding, stability, formulation, manufacturability, impact of further protein engineering. Such approaches are currently predicated on starting with good crystal structures closely represent those found under solution conditions simulated. A33 Fab, is an undeveloped immunotherapeutic antibody candidate was targeted human antigen homogeneously...
Complement Factor H (CFH), with 20 short complement regulator (SCR) domains, regulates the alternative pathway of in part through interaction its C-terminal SCR-19 and SCR-20 domains host cell-bound C3b anionic oligosaccharides. In solution, CFH forms small amounts oligomers, one self-association sites being SCR-16/20 domains. order to correlate function dimer formation occurrence rare disease-associated variants SCR-16/20, we identified dimerization site SCR-16/20. For this, expressed,...
Objective This multi-center study aims to investigate the PSA level, prostate volume, biopsy scheme and method of patients receiving in Chinese Prostate Cancer Consortium (CPCC) hospitals identify detection rate cancer (PCa) different ranges Chinese. Methods Detailed clinical information consecutive underwent 33 CPCC were recorded with EpiData Entry 3.1. Those included method. All statistics analysis was performed SPSS 17.0. T test applied compare age between groups. Mann-Whitney U...
Human complement factor H (CFH) plays a central role in regulating activated C3b to protect host cells. CFH contain 20 short regulator (SCR) domains and eight N-glycosylation sites. The N-terminal SCR mediate degradation while the C-terminal bind cell surfaces these. Our earlier study of Pichia-generated fragments indicated self-association site at SCR-17/18 that comprises dimerization for human H. Two N-linked glycans are located on SCR-17 SCR-18. Here, when we expressed without an E. coli...
<b><i>Purpose:</i></b> To investigate the optimal schemes of prostate biopsy according to volume (PV), age and transrectal ultrasound (TRUS) status in Chinese men. <b><i>Methods:</i></b> 923 consecutive patients who underwent initial TRUS-guided systematic 12-core (12PBx) were enrolled this study. The 12PBx was obtained by overlapping conventional sextant, lateral base, mid-gland peripheral zone apex. Each sample individually marked inked...
Abstract Beta-2-Glycoprotein I (β2GPI) is the main autoantigenic target of antiphospholipid syndrome (APS) with antibodies leading to clinical manifestations. There are two known structural isomers β2GPI, a J shape and circular shaped one. The transition between these structures incompletely understood, functional implications unknown. β2GPI substrate protease plasmin, which cleaves within fifth domain altered cellular binding. Very little currently regarding structure function this protein...