A5100694444- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Sarcoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Renal and Vascular Pathologies
- Asthma and respiratory diseases
- Circular RNAs in diseases
- Bone Tumor Diagnosis and Treatments
- Liver Disease Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Kidney Stones and Urolithiasis Treatments
- Radiomics and Machine Learning in Medical Imaging
- Bladder and Urothelial Cancer Treatments
- Hepatitis C virus research
- Cardiac tumors and thrombi
- Urticaria and Related Conditions
- Antioxidant Activity and Oxidative Stress
- Hepatitis B Virus Studies
- Colorectal Cancer Screening and Detection
- melanin and skin pigmentation
- Urologic and reproductive health conditions
- MicroRNA in disease regulation
- Soft tissue tumor case studies
- Cancer, Lipids, and Metabolism
First People's Hospital of Chongqing
2023-2025
Shandong Provincial Hospital
2025
Shandong First Medical University
2025
First Hospital of China Medical University
2025
China Medical University
2025
Xinjiang Medical University
2024
University of Arkansas for Medical Sciences
2024
The First People's Hospital of Xiaoshan District, Hangzhou
2023
Wenzhou Medical University
2023
Chongqing Medical University
2023
The incidence of prostate cancer (PCa) within Asian population used to be much lower than in the Western population; however, recent years and mortality rate PCa some countries have grown rapidly. This collaborative report summarized latest epidemiology information, risk factors, racial differences diagnosis, current status new trends surgery management novel agents for castration-resistant cancer. We believe such information would helpful clinical decision making urologists oncologists,...
Urinary tract infections (UTIs) are one of the most commonly encountered in clinical practice, which psychological stress is a critical pathological contributor to modulate immune function. However, mechanistic pathways linking networks brain bladder infection remain poorly understood. In this study, we discovered that acute treatment suppressed inflammation mice with UTIs, and significant number neurons showing overlap between inflammation-associated markers retrograde labeling were...
Multimodal gating is an essential feature of many TRP ion channels, enabling them to respond complex cellular environments. TRPV1, a pain receptor involved in nociception at the peripheral nerve terminals, can be activated by range physical and chemical stimuli (e.g., capsaicin, proton, heat) further sensitized proinflammatory substances. How single achieves this multiplicity functionality poorly understood molecular level. Here, we investigated structural basis proton activation TRPV1....
Staphylococcus aureus osteomyelitis leads to extensive bone destruction. Osteoclasts are resorbing cells that often increased in infected with S. aureus. The cytokine RANKL is essential for osteoclast formation under physiological conditions but vitro evidence suggests inflammatory cytokines may by-pass the requirement RANKL. goal of this study was determine whether RANKL-dependent loss occurs a murine model osteomyelitis. To end, humanized-RANKL mice were by direct inoculation into...
Spinal cord injury (SCI) is a serious disease of the central nervous system that associated with poor prognosis; furthermore, existing clinical treatments cannot restore nerve function in an effective manner. Inflammatory responses and increased production reactive oxygen species (ROS) microenvironment lesion are major obstacles inhibit recovery SCI. Small extracellular vesicles (sEVs), derived from mesenchymal stem cells, suitable options for cell-free therapy have been shown to exert...
ABSTRACT Objective To investigate the clinical efficacy of CGF combined with supramolecular salicylic acid cycle injection for melasma. Methods Twenty patients chloasma admitted to our hospital were selected and treated facial injection. After each injection, was given once. one treatment, severity melasma skin parameters before after treatment compared using modified Area Severity index (MASI) VISIA image analysis system, respectively. At same time, patients' self‐satisfaction investigated....
Abstract: Circulating tumor DNA (ctDNA) can be identified in the peripheral blood of patients and harbors genomic alterations found tissues, which provides a noninvasive approach for detection gene mutations. We conducted this meta-analysis to investigate whether ctDNA used monitoring KRAS mutations colorectal cancer (CRC) patients. Medline, Embase, Cochrane Library Web Science were searched included eligible studies English, data extracted statistical analysis according numbers...
Abstract: Cholesterol accounts for over one‐fourth of total myelin lipids. We found that, during development the rat sciatic nerve, expression mRNA hydroxymethylglutaryl‐coenzyme A (HMG‐CoA) reductase, rate‐limiting enzyme in cholesterol biosynthesis, was up‐regulated parallel with P 0 , major structural protein PNS myelin, and ceramide galactosyltransferase (CGT), cerebroside biosynthesis. To help establish nature this coordinate regulation myelin‐related genes, we examined their...
Human brain natriuretic peptide (BNP) is utilized in the treatment of acute decompensated congestive heart failure. However, BNP has limited clinical use owing to its rapid clearance and need for continuous intravenous infusion. Thus, we generated human serum albumin (HSA)-BNP fusion constructs produce long-acting proteins Pichia pastoris. Four proteins, BNP-HSA, (BNP)2-HSA, (BNP)4-HSA, HSA-(BNP)2, were constructed, with different numbers molecules orientations. BNP-HSA was most abundantly...
γ-tocotrienol (GT3), an analogue of vitamin E, has gained increasing scientific interest recently as it provides significant health benefits. It been shown that emulsified GT3, after subcutaneous administration, long-term biological effects. However, whether the effects are due to increase GT3 level in early phase following administration or persistent functions accumulation tissues is unknown. This study was conducted determine levels different by high performance liquid chromatography...
Gout is a common metabolic disease in humans, and it due to persistently elevated levels of uric acid the blood. At high levels, crystallizes crystals deposit joints surrounding tissues, resulting an attack gout. Interestingly, gout can spontaneously resolve within few days. However, self-limited mechanism remains elusive. It has been demonstrated that CD14 plays important role self-remission In this study, we found proportion CD14-positive PBMCs was decreased patients when compared with...
To evaluate the clinical value of serum asymmetrical dimethylarginine (ADMA) in patients with connective tissue disease- (CTD-) associated pulmonary arterial hypertension (PAH). 88 CTD were recruited between December 2017 and August 2018 Jiangxi Provincial People's Hospital. Patients further divided into two groups: CTD-without PAH (n = 45 cases) CTD-with 43 cases), according to systolic blood pressure measured by echocardiography. 40 healthy controls also included cases). The data,...
Liposarcomas of the kidney are exceedingly uncommon and represent less than 1% all malignant renal neoplasms.1 Here we report a case with liposarcoma presenting as huge retroperitoneal mass weighed 10 kg. CASE REPORT A 52-year-old woman presented 2-month history constant right flank discomfort voiding symptoms. She had no haematuria or urinary tract infections but palpable perirenal on physical examination. Routine blood test, including serum creatinine, urinalysis were unremarkable....
Objective This multi-center study aims to investigate the PSA level, prostate volume, biopsy scheme and method of patients receiving in Chinese Prostate Cancer Consortium (CPCC) hospitals identify detection rate cancer (PCa) different ranges Chinese. Methods Detailed clinical information consecutive underwent 33 CPCC were recorded with EpiData Entry 3.1. Those included method. All statistics analysis was performed SPSS 17.0. T test applied compare age between groups. Mann-Whitney U...
<sec> <title>BACKGROUND</title> While immunotherapy has revolutionized oncological management, its efficacy in lung cancer patients with liver metastases remains limited, potentially due to the unique immunosuppressive microenvironment of liver. Local treatment been shown enhance response, and high-intensity focused ultrasound (HIFU), a minimally invasive local treatment, demonstrated promising results combination immunotherapy. However, clinical data regarding HIFU are limited. </sec>...
Objective: To explore the efficacy and safety profile of tenofovir alafenamide fumarate (TAF) in treatment patients with decompensated hepatitis B cirrhosis. Methods: A two-way cohort study method was used to enroll cirrhosis who visited four medical centers, including Xinjiang Uygur Autonomous Region Hospital Traditional Chinese Medicine, from April 2021 2024 were treated TAF followed up for 48 weeks. The primary indicator virus (HBV) DNA seronegative conversion rate at 48-weeks, secondary...