A5036370316- Bone Tumor Diagnosis and Treatments
- TGF-β signaling in diseases
- Ocean Acidification Effects and Responses
- Marine Biology and Environmental Chemistry
- Osteomyelitis and Bone Disorders Research
- Cancer Diagnosis and Treatment
- Infectious Diseases and Tuberculosis
- Genetic factors in colorectal cancer
- Mesenchymal stem cell research
- Orthopedic Infections and Treatments
- Bone Metabolism and Diseases
University of Arkansas for Medical Sciences
2023-2024
Single-cell RNA sequencing has led to novel designations for mesenchymal cells associated with bone as well multiple what appear be the same cell type. The main goals of this study were increase amount single sequence data osteoblasts and osteocytes, compare from periosteum those inside bone, clarify major categories types murine bone. We created an atlas bone-associated by harmonizing published datasets in-house targeted Osx1-Cre Dmp1-Cre driver strains. Cells periosteal analyzed separately...
Staphylococcus aureus osteomyelitis leads to extensive bone destruction. Osteoclasts are resorbing cells that often increased in infected with S. aureus. The cytokine RANKL is essential for osteoclast formation under physiological conditions but vitro evidence suggests inflammatory cytokines may by-pass the requirement RANKL. goal of this study was determine whether RANKL-dependent loss occurs a murine model osteomyelitis. To end, humanized-RANKL mice were by direct inoculation into...
Abstract Single-cell RNA sequencing has led to numerous novel designations for mesenchymal cell types associated with bone. Consequently, there are now multiple what appear be the same type. In addition, existing datasets contain relatively small numbers of mature osteoblasts and osteocytes been no comparison periosteal bone cells those at endosteum trabecular The main goals this study were increase amount single sequence data osteocytes, compare from periosteum inside bone, clarify major...