A5102006840- Gallbladder and Bile Duct Disorders
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Intestinal Malrotation and Obstruction Disorders
- Pancreatic and Hepatic Oncology Research
- Orthopaedic implants and arthroplasty
- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Total Knee Arthroplasty Outcomes
- Liver Disease Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Hepatocellular Carcinoma Treatment and Prognosis
- Biliary and Gastrointestinal Fistulas
- Congenital Anomalies and Fetal Surgery
- Liver physiology and pathology
- Minimally Invasive Surgical Techniques
- Renal cell carcinoma treatment
- Urological Disorders and Treatments
- Abdominal Trauma and Injuries
- Orthopedic Infections and Treatments
- Appendicitis Diagnosis and Management
- Peptidase Inhibition and Analysis
- Drug-Induced Hepatotoxicity and Protection
- Retinoids in leukemia and cellular processes
Sichuan University
2010-2025
West China Hospital of Sichuan University
2010-2025
Weatherford College
2021-2024
Orthopaedic Hospital
2024
Zhengzhou People's Hospital
2024
Mayo Clinic
2024
Shanghai Jiao Tong University
2013-2023
Shanghai First People's Hospital
2022-2023
Jilin University
2023
Binzhou University
2023
To detect the feasibility of using synchronous bile duct, left lobe liver and common hepatic artery resection without reconstruction to improve therapeutic efficacy HC.A total 19 patients with hilar cholangiocarcinoma undergoing left-sided hepatectomy, right duct-jejunum anastomosis from June 2005 May 2010 in our team were included prospectively this study.One case died probable sudden myocardial infarction before discharge hospital. Little leakage occurred one case. No insufficiency...
Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases after extended resections, resulting in the inability to maintain or restore sufficient functional mass. Therapies are lacking, making transplantation only curative option for end-stage disease. Here, we report on structure-based development characterization (nuclear magnetic resonance [NMR] spectroscopy) first-in-class small molecule inhibitors dual-specificity kinase MKK4 (MKK4i). MKK4i increased upon...
Cholestasis is a common disease with broad aetiologies. The NOD-like receptor protein 3 (NLRP3) pathway has been demonstrated to play an important role in liver injury and fibrosis induced by cholestasis. We previously proved that MCC950, selective NLRP3 inhibitor, alleviates experimental cholestasis bile-duct ligation (BDL) mice. Herein, we investigate the of calcipotriol, potent vitamin D agonist, cholestasis, test its therapeutic efficacy, explore potential protective mechanism. C57BL/6...
Spinal cord injury (SCI) is a serious disease of the central nervous system that associated with poor prognosis; furthermore, existing clinical treatments cannot restore nerve function in an effective manner. Inflammatory responses and increased production reactive oxygen species (ROS) microenvironment lesion are major obstacles inhibit recovery SCI. Small extracellular vesicles (sEVs), derived from mesenchymal stem cells, suitable options for cell-free therapy have been shown to exert...
Background Although gastrointestinal stromal tumors (GISTs) are the most common mesenchymal of tract, they rare in children, particularly those located on duodenum. Here, we present an interesting pediatric case involving a 13-year-old boy who experienced hemorrhage, he was misdiagnosed with tumor major duodenal papilla and ultimately confirmed to be GISTs. Case presentation A presented local hospital fatigue melena. Gastroscopy suggested at papilla, patient referred our for surgical...
Aim . To investigate the role of vitamin A in liver damage induced by bile duct ligation (BDL) rats. Methods Thirty male Wistar rats were randomly divided into three groups: SHAM group, BDL and + VitA group The concentrations retinol retinyl palmitate analyzed using HPLC, function was evaluated level TBIL, ALT, AST, ALP serum. Hepatic oxidative status estimated measuring T-SOD, CAT, GSH, MDA, AOPP. Nrf2 expression assessed immunohistochemistry western blotting, EMSA performed to determine...
The purpose of this study is to introduce our preliminary experiences with using the da Vinci surgical system treat choledochal cysts in children under 1 year old and discuss application robot-assisted surgery. We retrospectively analyzed all available clinical data below age who underwent surgery for robotic between January 2015 December 2020. Data collection mainly included demographic information, imaging data, perioperative details, postoperative outcomes. Ten patients were study....
Mucormycosis is a rare but invasive opportunistic fungal infection associated with high mortality rate, and normally occurs in immunocompromised patients.In this report, we describe an immunocompetent patient suffering from hepatic mucormycosis secondary to adrenal mucormycosis, which masquerades as hilar cholangiocarcinoma.After surgical procedure treatment amphotericin B itraconazole, the recovered well had 2-year infectionfree survival.To our knowledge, special clinical manifestation of...
Clip migration into the common bile duct (CBD) is a rare but well-established phenomenon of laparoscopic biliary surgery. The mechanism and exact incidence clip are both poorly understood. can cause recurrent cholangitis serve as nidus for stone formation. We present case, 54-year-old woman, clip-induced resulting from surgical 12 months after cholecystectomy exploration (LC+LCBDE) with primary closure.
To assess the surgical safety of synchronous hepatic resection and splenectomy for patients with hepatocellular carcinoma (HCC) hypersplenism.Patients HCC hypersplenism who underwent treatment were included in this study. According to difference operations, divided into two groups (group A, resection; group B, hypersplenism). Pre- intra-operative parameters statistically analyzed. Postoperative outcomes including white blood cell platelet count changes, complications long-term survival rates...