A5001445633- Organ Transplantation Techniques and Outcomes
- Liver Disease and Transplantation
- Liver physiology and pathology
- Renal Transplantation Outcomes and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Tissue Engineering and Regenerative Medicine
- Transplantation: Methods and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Biomarkers in Disease Mechanisms
- Liver Disease Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Xenotransplantation and immune response
- Venous Thromboembolism Diagnosis and Management
- Genetic and Kidney Cyst Diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Drug-Induced Hepatotoxicity and Protection
- Gallbladder and Bile Duct Disorders
- Electrospun Nanofibers in Biomedical Applications
- Pancreatic and Hepatic Oncology Research
- Innovations in Medical Education
- Simulation-Based Education in Healthcare
- Colorectal Cancer Treatments and Studies
- Circular RNAs in diseases
- Herpesvirus Infections and Treatments
Medizinische Hochschule Hannover
2024-2025
Mayo Clinic
2023-2024
Mayo Clinic in Arizona
2022-2024
WinnMed
2024
Jena University Hospital
2017-2023
Leipzig University
2012-2020
University Hospital Leipzig
2016-2020
University Hospital Münster
2020
Schwarzwald-Baar Klinikum
2020
Helios Park-Klinikum Leipzig
2020
Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases after extended resections, resulting in the inability to maintain or restore sufficient functional mass. Therapies are lacking, making transplantation only curative option for end-stage disease. Here, we report on structure-based development characterization (nuclear magnetic resonance [NMR] spectroscopy) first-in-class small molecule inhibitors dual-specificity kinase MKK4 (MKK4i). MKK4i increased upon...
Recently, initial clinical experience has been gained with the xenotransplantation of pig organs such as heart and kidney into terminally ill human patients in an effort to overcoming organ shortage. Here, we investigated use normothermic machine perfusion (NMP) advance research develop bridging therapies for acute failure livers a liver dialysis system. We simultaneously analyzed lungs from genetically modified pigs, carrying knock-out GGTA1 gene, which is essential xenoreactive...
Zusammenfassung Die Vorteile minimalinvasiver Operationstechniken sind unbestritten. Mit der Einführung robotischer Assistenzsysteme wurde die klassische Laparoskopie weiterentwickelt und wird nun auch in bisher von offenen Operationsverfahren geprägten Transplantationschirurgie eingesetzt, insbesondere bei Lebendspende-Operationen Leber Niere. Um den aktuellen Stand Implementierung robotischen Assistenzsystemen zu untersuchen, wurden Ergebnisse internationaler Studien auf diesem Gebiet...
Perihilar cholangiocarcinoma (Klatskin tumor) is a rare tumor entity, which diagnosed late due to uncharacteristic symptoms. The therapeutic strategy for cure still liver resection. Liver transplant in cases of locally irresectable tumors represents an alternative potential curative therapy select group patients.We present our data 22 patients with Klatskin who received transplants between 1996 and 2015. We analyzed relevant prognostic factors the selection be transplanted ensure acceptable...
Context: Non-invasive markers for diagnosis of acute rejection (AR) following liver transplantation have not been developed, yet.Objective: We analyzed the correlation plasma microparticle levels (MP) with AR.Materials and Methods: MP (CD4, CD8, CD25, CD31, MHC) 11 AR patients controls were within first week after transplantation.Results: CD4, CD8 CD31 positive higher in AR, whereas overall count, CD25 MHCI proportions did differ between both groups.Discussion Conclusion: dynamics period...
Abstract Background The Milan criteria (MC) are widely used for the indication of liver transplantation (LTx) in hepatocellular carcinoma (HCC). Good long-term results have also been reported following LTx patients exceeding MC. In this article, we compare overall and recurrence-free survival our fulfilling MC according to post-transplant histopathological results. Patients methods Data from 120 with HCC (22 females 98 males) were analyzed. median patient age was 61 years (Q1, Q3 54.7,...
BackgroundBiological organ engineering is a novel experimental approach to generate functional liver grafts by decellularization and repopulation. Currently, healthy organs of small or large animals human with preexisting diseases are used optimize repopulation.However, the effects morphological changes on allo- xenogeneic cell-scaffold interactions during repopulation procedure, e.g., using scaffold-sections, unknown. We present sequential workflow identify murine scaffold-sections...
Abstract Purpose Here, we analyse the technical modification of ALPPS procedure, ligating middle hepatic vein during first step operation to enhance remnant liver hypertrophy. Methods In 20 37 procedures, was ligated step. Hypertrophy functional volume assessed in addition postoperative courses. Results Volumetric analysis showed a significant increase, especially for patients with colorectal metastases. Pre-existing parenchyma damage (odds ratio = 0.717, p 0.017) and preoperative...
Context: Alcoholic liver cirrhosis is a significant risk factor for the development of hepatocellular carcinoma (HCC). The importance tumour-associated in or progression HCC not understood. MiRNAs are important regulators development, but their role due to alcoholic unclear.Objective: aim this study detection miRNA expression cirrhosis, and HCC.Materials methods: We analysed differences profiles HCC, without samples from 30 patients who underwent transplantation because disease.Results:...
In patients suffering from autosomal dominant polycystic liver and kidney disease (ADPLKD), combined organ transplantation often poses a technical challenge due to the large volume of both organs. To simplify procedure by improving exposure anatomical structures, we introduce novel surgical technique orthotopic transplantation.The modified simultaneous via right-sided L-incision included three steps: (1) nephrectomy in recipient followed (2) cava replacement (3) with arterial reconstruction...
Introduction The development of animal models chronic liver disease via diet modification is a promising avenue for translational research but can lead to unexpected side effects that impact model adoption. While these are well characterized in rodent nonalcoholic steatohepatitis (NASH), limited knowledge exists novel porcine NASH. To close this gap, the present study investigates diet-based NASH induction pigs, with systematic analysis pathologic mechanisms underlying dermatitis and...
Introduction Acute liver failure (ALF) is defined as acute loss of function leading to hepatic encephalopathy associated with a high risk patient death. Brain injury markers in serum and tissue can help detect monitor ALF-associated brain injury. This study compares different parameters plasma along the progression ALF. Method ALF was induced by performing an 85% resection. Following resection, animals were recovered monitored for up 48 h or until reaching predefined endpoint receiving...
In this study, a mixed porcine–human bioengineered liver (MPH-BEL) was used in preclinical setup of extracorporeal support devices as treatment for model post-resection failure (PRLF). The potential human clinical application is further illustrated by comparing the functional capacity MPH-BEL grafts assessed using porcine PRLF with fully (FH-BEL) which were perfused and vitro. BEL produced reseeding scaffolds HUVEC primary hepatocytes or (FH-BEL). induced performing an 85% resection domestic...
Physicians are faced with a growing number of patients after renal transplantation undergoing graft-unrelated surgery. So far, little is known about the postoperative restitution graft function and risk factors for poor outcome. One hundred one kidney transplant recipients surgery between 2005 2015 were reviewed retrospectively. A analysis was performed differences in creatinine, GFR immunosuppressive treatment evaluated. Additional, comparison case-matched non-transplanted control group...
Der Begriff der „Generation Y“ ist längst nicht mehr einfach nur eine Modeerscheinung, er scheint inzwischen reale Bedrohung chirurgischen Zukunft darzustellen. Gerade von etablierten Medizinern wird immer wieder infrage gestellt, ob die junge Generation überhaupt noch dazu in Lage ist, gute Grundversorgung, sondern vielmehr auch auf Fortschritt bedachte innovative Medizin zu gewährleisten. Y steht im Zwiespalt zwischen dem Wunsch nach einem geregelten Sozialleben und den hohen Anforderungen...
Objectives Acute drug-induced liver failure is a rare indication for transplant. There only one case of flupirtine-induced requiring transplant in the literature. In February 2018, European Medicines Agency issued withdrawal approval flupirtine medication countries as result risk acute failure. Materials and methods The aim this study was German-wide collection data regarding patients with flupirtine-associated Results A total 9 received transplants. All were women mean age 43 years....
Introduction: The indication for liver transplantation (LTx) in case of hepatocellular carcinoma (HCC) is still a sensitive issue since the validation Milan Criteria has been objectively criticized numerous studies. microRNA (miRNA) are currently widely investigated as biomarkers establishment personalized medicine and oncology. miRNA have already introduced diagnosis graft rejection or tolerance cancer diagnosis; however published profiles HCC discordant couldn't verified prospective...