A5011448604- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Tracheal and airway disorders
- Airway Management and Intubation Techniques
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Transplantation: Methods and Outcomes
- Trauma Management and Diagnosis
- Lung Cancer Treatments and Mutations
- Mechanical Circulatory Support Devices
- Esophageal and GI Pathology
- Medical Imaging and Pathology Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Reconstructive Surgery and Microvascular Techniques
- Orthopedic Infections and Treatments
- Infectious Diseases and Tuberculosis
- Respiratory viral infections research
- Foreign Body Medical Cases
- Asthma and respiratory diseases
- Lung Cancer Research Studies
- Sarcoma Diagnosis and Treatment
- Surgical site infection prevention
- Inhalation and Respiratory Drug Delivery
- Cardiac, Anesthesia and Surgical Outcomes
- Cancer Diagnosis and Treatment
Medizinische Hochschule Hannover
2012-2025
German Center for Lung Research
2018-2025
Otto-von-Guericke University Magdeburg
2014-2017
University Hospital Magdeburg
2014-2017
Klinikum Magdeburg
2015
Federal Ministry of Education and Research
2013
Klinikum Region Hannover
2006
Background: Robotic-assisted thoracic surgery (RATS) has seen increasing interest in the last few years, with most procedures primarily being performed conventional multiport manner. Our team developed a new approach that potential to convert surgeons from uniportal video-assisted (VATS) or open robotic-assisted surgery, uniportal-RATS (U-RATS). We aimed evaluate outcomes of one single incision, (OSI-RATS) against standard RATS (M-RATS) regards safety, feasibility, surgical technique,...
Respiratory diseases in their broad diversity need appropriate model systems to understand the underlying mechanisms and enable development of new therapeutics. Additionally, registration substances requires risk assessment with adequate testing avoid individuals being harmed, for example, working environment. Such assessments are usually conducted animal studies. In view 3Rs principle public skepticism against experiments, human alternative methods, such as precision-cut lung slices (PCLS),...
Recently, initial clinical experience has been gained with the xenotransplantation of pig organs such as heart and kidney into terminally ill human patients in an effort to overcoming organ shortage. Here, we investigated use normothermic machine perfusion (NMP) advance research develop bridging therapies for acute failure livers a liver dialysis system. We simultaneously analyzed lungs from genetically modified pigs, carrying knock-out GGTA1 gene, which is essential xenoreactive...
Pulmonary Fibrosis (PF) is a life-threatening illness that characterized by progressive scarring in the lung interstitium. There an urgent need for new PF therapies because current treatments only slow down progression of fibrosis and median life expectancy post-diagnosis 4 to 6 years. Since patients frequently exhibit telomere attrition, overexpressing telomerase, enzyme responsible synthesizing telomeres represents compelling therapeutic option. In this study, we vitro transcribed human...
Introduction: Lung volume reduction surgery (LVRS) is an important treatment option for patients with advanced emphysema and typically performed in a non-anatomical fashion. This study reports the outcome of anatomical LVRS by means uniportal video-assisted thoracoscopic (VATS). Methods: We retrospectively evaluated who underwent between June 2017 September 2023 at our institution. Patient characteristics, including demographic data, lung function, as well morbidity mortality were extracted...
Non-small cell lung cancer (NSCLC) accounts for about 85% of cancers, and is the leading cause tumor-related death. Lung adenocarcinoma (LUAD) most prevalent subtype NSCLC. Although significant progress LUAD treatment has been made under multimodal strategies, prognosis advanced still poor due to recurrence metastasis. There a lack reliable markers evaluate prognosis. This study aims explore novel biomarkers construct prognostic model predict patients.
Objective: This study analyses the efficacy of bovine Peri-Guard Repair Patch® for chest wall reconstruction. Methods: Nine consecutive patients (seven males, median age: 61 years) underwent repair due to either secondary incisional herniation development after lung transplantation (LTX, n = 3 patients) or malignant disease with infiltration. In all cases, was performed a (Synovis, St. Paul, MN, USA). At follow-up (4 ± 2 months), quality life, signs re-herniation and incorporation mesh...
Non-intubated uniportal video-assisted thoracoscopic surgery (niVATS) is a novel approach to major and minor lung resection. It benefits from holistic anesthesiological concept with adequate pain relief sedation in minimal-invasive setup allowing thoracic procedures under spontaneous breathing. At present no gold standard for niVATS exists. The primary aim of our retrospective observational study was evaluate feasibility safety minimally invasive both pulmonary resections at institution.All...
Human rhinovirus (RV) is a major risk factor for chronic obstructive pulmonary disease (COPD) and asthma exacerbations. The exploration of RV pathogenesis has been hampered by lack disease-relevant model systems. We performed detailed characterization host responses to infection in human lung tissue ex vivo investigated whether these are relevant patients with COPD asthma. In addition, impact the viral replication inhibitor rupintrivir was evaluated. precision-cut slices (PCLS) were infected...
Abstract Introduction Advanced or metastatic soft tissue sarcoma (a/mSTS) is associated with a dismal prognosis. Patient counseling on treatment aggressiveness pivotal to avoid over- undertreatment. Recently, evaluation of body composition markers like the skeletal muscle index (SMI) became focus interest in variety cancers. This study focuses prognostic impact SMI a/mSTS, retrospectively. Methods 181 a/mSTS patients were identified, 89 eligible due prespecified criteria for assessment....
At present only few studies directly compare the diagnostic yield of endobronchial ultrasound guided fine needle aspiration (EBUS-FNA) and transcervical video-assisted mediastinoscopy (TM) for mediastinal lymph node staging in patients with NSCLC. If when EBUS-FNA may replace TM as Gold Standard remains controversial. From April 2008 to December 2009, 36 lymphadenopathy underwent simultaneous EBUS-FNA/ at our institution. Among them were 26 confirmed or suspected A total 133 samples obtained...
Respiratory diseases in their broad diversity need appropriate model systems to understand the underlying mechanisms and enable development of new therapeutics. Additionally, registration substances requires risk assessment with adequate testing avoid individuals being harmed, for example, working environment. Such assessments are usually conducted animal studies. In view 3Rs principle public skepticism against experiments, human alternative methods, such as precision-cut lung slices (PCLS),...
Background: We sought to analyze the efficacy of a bovine pericardial patch (PeriGuard®) for diaphragmatic repair. Methods: Seven consecutive patients (6 males, median age 56 years) scheduled resection and/or repair were enrolled in this study. In all cases was performed with PeriGuard Repair Patch® (Synovis, St. Paul, MN, USA). At follow-up (median: 12 months; range: 6–18 months), quality life, signs reherniation and incorporation mesh assessed through clinical examination, blood samples CT...
Albumin-glutaraldehyde glue gained a widespread acceptance in repair of superficial lung defects associated with alveolar air leaks (AAL). As its sealing efficacy has not yet been thoroughly corroborated by clinical studies, we sought to assess the properties commercially available albumin-glutaraldehyde (BioGlue™) an vitro model. The lower lobe freshly excised swine (n = 10) was intubated and ventilated. A focal parenchymal defect (40 × 25 mm) created on inflated lung. AAL assessed...
Yanran Zhou, Hengrui Liang, Ke Xu, Chao Yang, Lixia Qinglong Dong, Hanyu Hui Liu, Yinfen Li, Setu Patolia, Jinwook Hwang, Patrick Zardo, Shuben Jianxing He, Jun Liu
<b>Background</b> Incidental solitary pulmonary nodules (ISPN) detected prior to scheduled cardiac surgery are rare but challenging. We evaluated the long-term outcome of patients with ISPN undergoing simultaneous and lung surgery. <b>Methods</b> The clinical records 33 consecutive surgery, either simultaneously (<i>n</i> = 30) or sequentially 3), were retrospectively completed by detailed follow-up. <b>Results</b> On histological examination, 14 cases (42.4%) primary NSCLC identified....
We present a case of impassable subglottic stenosis scheduled for tracheal resection and reconstruction managed by establishing supraglottic airway. Despite careful preoperative evaluation, the was localized higher than anticipated, rendering conventional intubation impossible. Laryngeal mask bridging to cross-field ventilation feasible jet cardiopulmonary bypass were available as emergency strategies. Surgery emergence went uneventful. Perioperative considerations are discussed in this report.
Background: Uniportal video-assisted thoracic surgery (VATS) basal segmentectomy is technically challenging and requires a deep understanding of the segmental anatomy lung. This report describes uniportal VATS segments using single-direction approach. Methods: A total 49 patients who underwent between April 2019 2021 were included in this retrospective study. All surgeries conducted The resections 7–8 mainly performed interlobar fissure approach, while 9–10 inferior pulmonary ligament...