A5032344429- Liver physiology and pathology
- Tissue Engineering and Regenerative Medicine
- Pluripotent Stem Cells Research
- Organ Transplantation Techniques and Outcomes
- Pancreatic function and diabetes
- Electrospun Nanofibers in Biomedical Applications
- Xenotransplantation and immune response
- Esophageal and GI Pathology
- Genetic factors in colorectal cancer
- Gastroesophageal reflux and treatments
- Cancer Mechanisms and Therapy
- Trauma and Emergency Care Studies
- Colorectal and Anal Carcinomas
- Salivary Gland Tumors Diagnosis and Treatment
- Blood transfusion and management
- PI3K/AKT/mTOR signaling in cancer
- Gastrointestinal Tumor Research and Treatment
- Inflammatory Bowel Disease
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- RNA modifications and cancer
- Congenital Diaphragmatic Hernia Studies
- Ubiquitin and proteasome pathways
- Colorectal Cancer Treatments and Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
Roswell Park Comprehensive Cancer Center
2023-2024
Mayo Clinic
2017-2024
Mayo Clinic in Arizona
2018-2021
Boston University
2018
WinnMed
2017
Diminished hepatocyte regeneration is a key feature of acute and chronic liver diseases after extended resections, resulting in the inability to maintain or restore sufficient functional mass. Therapies are lacking, making transplantation only curative option for end-stage disease. Here, we report on structure-based development characterization (nuclear magnetic resonance [NMR] spectroscopy) first-in-class small molecule inhibitors dual-specificity kinase MKK4 (MKK4i). MKK4i increased upon...
Eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) is regulated by the mTOR (mammalian target of rapamycin) signaling pathway. Phosphorylated EIF4EBP1 leads to pathway activation and correlates with aggressive breast cancer features. However, clinical relevance
Organ bioengineering offers a promising solution to the persistent shortage of donor organs. However, progression this technology toward clinical use has been hindered by challenges reconstituting functional vascular network, directing engraftment specific cell types, and defining appropriate culture conditions concurrently support health phenotypic stability diverse lineages. We previously demonstrated ability functionally reendothelialize vasculature clinically scaled decellularized liver...
Background: Adenosquamous carcinomas (ASCs) are a very rare histology containing cancer cells with both glandular-like (adeno) and squamous cell histologies, comprising typically fraction of percent all solid tumors. The bulk the literature on ASCs is comprised case reports small series, general finding that tend to have worse outcomes than either their parent histologies. However, there lack pan site-comparative studies in compare ASC clinicodemographic survival those conventional...
Mucinous (colloid) adenocarcinomas (MAs) are a rare histological subtype of tumors defined by extracellular mucin comprising more than 50% the tumor. These on continuum mucin-producing malignancies with signet ring cell (SRCCs), which instead produce intracellular mucin. Mucin-containing cancers occur primarily in stomach and colon, where for SRCCs, outcomes relatively worse proximal rectum. It is not known if MAs have similar outcomes. In this study, we use Surveillance, Epidemiology, End...
Biliary complications (strictures and leaks) represent major limitations in living donor liver transplantation. Mesenchymal stem cells (MSCs) are a promising modality to prevent biliary because of immunosuppressive angiogenic properties. Our goal was evaluate the safety adipose-derived MSC delivery anastomoses porcine model. Secondary objectives were defining optimal method (intraluminal versus extraluminal) investigate engraftment, angiogenesis, fibrosis. Pigs divided into 3 groups. Animals...
The mammalian liver's regenerative ability has led researchers to engineer animals as incubators for expansion of human hepatocytes. properties hepatocytes in immunodeficient mice are well known. However, little been reported about larger that more scalable and practical clinical purposes. Therefore, we engineered swine support identify barriers their application. Immunodeficient were by knockout the recombinase-activating gene 2 (RAG2) fumarylacetoacetate hydrolase (FAH). Immature (ihHCs)...