A5101788855- Radiopharmaceutical Chemistry and Applications
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Neuroendocrine Tumor Research Advances
- Prostate Cancer Treatment and Research
- Advanced biosensing and bioanalysis techniques
- Pancreatic function and diabetes
- HER2/EGFR in Cancer Research
- Diabetes Treatment and Management
- Growth Hormone and Insulin-like Growth Factors
- Protease and Inhibitor Mechanisms
- Genetic and phenotypic traits in livestock
- Luminescence and Fluorescent Materials
- Nanoparticle-Based Drug Delivery
- RNA and protein synthesis mechanisms
- Phytochemical and Pharmacological Studies
- Lung Cancer Diagnosis and Treatment
- Biosensors and Analytical Detection
- Migraine and Headache Studies
- Meat and Animal Product Quality
- S100 Proteins and Annexins
- Chemical Synthesis and Reactions
- Antimicrobial Peptides and Activities
- Neuropeptides and Animal Physiology
- Nanoplatforms for cancer theranostics
Kumamoto University
2025
Osaka University
2025
Key Laboratory of Nuclear Radiation and Nuclear Energy Technology
2020-2024
Janssen (United States)
2023
Ministry Of Health
2013-2019
Laboratory of Molecular Genetics
2015-2019
Teva Pharmaceuticals (United States)
2015-2019
Wuxi Institute of Technology
2015-2016
Affiliated Hospital of Qingdao University
2015
Sichuan Agricultural University
2015
Currently, there is no curative treatment for inflammatory bowel disease (IBD), which has an increased risk of colitis-associated cancer. Corticosteroids are the main clinical IBD therapeutics but have significant side effects. Even heavy corticosteroid use can result in failure may lead to resective surgery. In this study, we designed one type new drug-delivery system (DDS) delivering dexamethasone (DEX), anti-inflammation corticosteroid, therapy. This DDS was screened by...
Ferroptosis and autophagy are the two forms of regulation cell death that play important roles in cancer therapy. However, little is known about combination therapeutic effects ferroptosis Here, this study, we constructed a novel carrier-free nanodrug called nanoparticle ferritin-bound erastin rapamycin (NFER). The NFER was prepared by emulsification technique; it exhibited an average size 78.8 nm zeta potential -25.9 ± 3.3 mV. Controllable drug encapsulation efficiency loading ratios could...
The detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial for preventing and controlling infectious diseases disease treatment. In this work, a Au@Ti3C2@PEI-Ru(dcbpy)32+ nanocomposite-based electrochemiluminescence (ECL) biosensor was rationally designed, which realized sensitive RNA-dependent RNA polymerase (RdRp) gene SARS-CoV-2. addition, DNA walker also used to excise hairpin DNAs under action Nb.BbvCI endonuclease. Furthermore, model DNA-Ag...
CRISPR/Cas12a-based biosensing is advancing rapidly; however, achieving sensitive and cost-effective reporting of Cas12a activation remains a challenge. In response, we have developed label-free system capable postamplifying by integrating hybridization chain reaction (HCR) DNA-copper nanoclusters (DNA-CuNCs). The trans-cleavage triggers silenced HCR, leading to the in situ assembly fluorescent DNA-CuNCs, allowing for turn-on activation. Without preamplification, this assay can detect DNA...
Nonfluorescent succinimides become fluorescent only by thiol and amine group substitutions, without employing any units.
Abstract Self‐assembled supramolecular nanoparticles have remarkable benefits in bioimaging and drug delivery. Here it is first reported that polyphenol poloxamer self‐assemble (PPNPs). PPNPs are fabricated by multivalent hydrogen bonding between tannic acid Pluronic F‐127 together with hydrophobic interactions of poly(propylene oxide) chains, to be applied tumor near‐infrared fluorescence (NIRF) imaging positron emission tomography (PET) imaging. With fluorescent dyes such as IR780...
For commercial production of SGLT2 inhibitors, cryogenic conditions (-78 °C) were required at the key C-glycosidation step, which has restricted their supply to world market. To address challenge, reported herein is a new synthetic method based on ketone synthesis by means copper(I)-catalyzed coupling 2-pyridylthioesters with Grignard reagents. The facile transformation from ketones final APIs was realized under mild due use readily cleavable acetyl protecting groups.
A new protocol for preparing thioesters from the corresponding methyl esters was developed using i PrMgCl and odorless 1-dodecanthiol, n C12H25SH, under mild reaction conditions, during which in situ-generated C12H25SMgCl selectively reacted with carbonyl group of esters. variety aromatic aliphatic were readily converted up to 99% yield excellent functional tolerance. Furthermore, based on quantitative formation thioesters, we successfully applied our method a one-pot synthesis ketones aldehydes
DOX loaded ferritin selectively induces ferroptosis enhanced killing of transferrin receptor 1 overexpressed cancer cells.
Background: High expression of glucagon-like peptide-1 receptor (GLP-1R) in insulinoma supplies a potential drug target for tumor imaging. Exendin-4 can specifically bind to GLP-1R as an agonist and its analogs are extensively used imaging studies.Purpose: A new agent, [18F]AlF-NOTA-MAL-Cys39-exendin-4, was designed prepared imaging.Methods: Cys39-exendin-4 conjugated with NOTA-MAL, then the compound radiolabeled [18F]AlF complex obtained [18F]AlF-NOTA-MAL-Cys39-exendin-4. The...
Background: Human epidermal growth factor receptor type 2 (HER2) is abundant in a wide variety of tumors and associated with the poor prognosis. Radiolabeled affibodies are potential candidates for detecting HER2-positive lesions. However, laborious multiple-step synthetic procedure high abdomen background may hinder widespread use. Herein, cysteinylated ZHER2:342 modified new hydrophilic linker (denoted as MZHER2:342) was designed labeled using 18FAl-NOTA strategies. The biologic efficacy...
Combining aminolysis of thiolactones and amine-maleimide Michael addition contributed to the synthesis fluorescent aliphatic poly(amide-imide)s, accomplishing excellent solubility <italic>via in situ</italic> PEGylation.
The Liangshan pig is a traditional Chinese small-sized breed; it has relatively long feeding period and low meat production ability but superior quality. This study utilized three non-linear growth models (Von Bertalanffy, Gompertz, logistic) to fit the curve of pigs from an unselected, random-bred population estimate most suitable slaughter weight. development data at 20 time points 275 (from birth 250 d) were collected. To analyze relative gene expression related development, seven weight...
Introduction: Stereotactic ablative radiotherapy (SABR) is a relatively new technique for the curative-intent treatment of patients with inoperable early-stage non-small-cell lung cancer (NSCLC). Previous studies have demonstrated prognostic value positron emission tomography–computed tomography (PET/CT) parameters, including maximal standardized uptake (SUVmax), metabolic tumour volume (MTV), and total lesion glycolysis (TLG) in patients. We aimed to determine which pet/ct parameter most...
Objective: Overexpression of human epidermal growth factor receptor-2 (HER2) in breast cancers provides promising opportunities for imaging and targeted therapy. Developing HER2 positron emission tomography (PET) probes might be benefit management the disease. Small high-affinity scaffold proteins, affibodies, are ideal vectors overexpressed tumors. Despite initial success on development 18F labeled ZHER2:342 affibody, tedious synthesis producers, low yields unfavorable pharmacokinetics may...
Improving iron-chelating drugs for the safe and efficient therapy of iron overload disease is greatly challenging highly desired. Endogenous chelators are perfect candidates because their intrinsic biodegradability biocompatibility, which avoid severe side effects exogenous currently present in clinical applications. Herein, first time, we have reported simply using melanin nanoparticles as an natural nano-drug living mice. Its native biodegradability, high iron-capturing volume long...
Inspired by brachytherapy radioiodine seeds, radioiodine-labelled melanin nanoparticles with several advantages were developed for theranostic applications.
Animal growth curves can provide essential information for animal breeders to optimize feeding and management strategies. However, the genetic mechanism underlying phenotypic differentiation between inflection point asymptotic stages of curve is not well characterized. Here, we employed Liangshan pigs in at (under point: UIP) two (before BIP, after AIP) as models survey global gene expression longissimus dorsi muscle using digital (DGE) tag profiling. We found reached maximum rate (UIP)...
Nonconjugated red fluorescent polymers have been increasingly studied to improve the biocompatibility and penetration depth over conventional materials. However, accessibility of such remains challenging due scarcity nonconjugated fluorophores lacking relevant mechanism red-shifted fluorescence. Herein, we discovered that combination hydrogen bonding π-π stacking interactions provides poly(amide-imide) with a large bathochromic shift (>100 nm) from blue-green fluorescence emission. The...