A5101681500- Advanced biosensing and bioanalysis techniques
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- CRISPR and Genetic Engineering
- Carbon and Quantum Dots Applications
- RNA Interference and Gene Delivery
- Advanced Nanomaterials in Catalysis
- Electrochemical sensors and biosensors
- Nanocluster Synthesis and Applications
- Biosensors and Analytical Detection
- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Drug Delivery Systems
- Essential Oils and Antimicrobial Activity
- RNA and protein synthesis mechanisms
- Glycosylation and Glycoproteins Research
- Proteoglycans and glycosaminoglycans research
- Microbial Community Ecology and Physiology
- Diabetes Treatment and Management
- Carbohydrate Chemistry and Synthesis
- Blood Pressure and Hypertension Studies
- RNA Research and Splicing
- Molecular Sensors and Ion Detection
- RNA regulation and disease
- SARS-CoV-2 and COVID-19 Research
- Ziziphus Jujuba Studies and Applications
University of Missouri
2025
Conemaugh Memorial Medical Center
2024-2025
Our Lady of Fatima Hospital
2025
Conemaugh Health System
2025
Lishui University
2025
Zhejiang University
2025
Nanjing Normal University
2020-2024
King Edward Medical University
2016-2024
Mayo Hospital
2016-2024
University of Education
2024
The activity of the protein kinase Akt is frequently dysregulated in cancer and an important factor growth survival tumour cells. activation involves phosphorylation two residues: threonine 308 (Thr308) loop serine 473 (Ser473) C-terminal hydrophobic motif. Phosphorylation Ser473 has been extensively studied samples as a correlate for activity, yet Thr308 or downstream substrates rarely assessed.The status was compared with that three separate - PRAS40, TSC2 TBC1D4 fresh frozen early-stage...
In this work, a new kind of N, Cu codoped carbon dots (N/Cu-CDs) was prepared via facile one-pot hydrothermal method by using citric acid monohydrate, copper acetate monohydrate and diethylenetriamine. The N/Cu-CDs with high quantum yield (50.1%) showed excitation-independent emission at 460 nm. structure fluorescence properties were characterized high-resolution transmission electron microscopy, spectrofluorometer, FT-IR spectrometer, UV-visible spectrophotometer X-ray photoelectron...
In this work, a new magnetic, ratiometric fluorescent nanoprobe has been designed and fabricated by encapsulating Fe3O4 magnetic nanoparticles (MNPs) dual-emissive carbon dots into the cavities of metal-organic frameworks (MOFs). This one-pot method combined hybrid characteristics MOFs with multiple properties encapsulated functional materials. The MOF-based possessed advantages (strong adsorption ability, accumulating analytes), MNPs (magnetic separation), sensors (eliminating variabilities...
A new ratiometric fluorescent sensor (QDs/CDs@ZIF-8) combining the advantages of ratiometry and MOFs was synthesized for Cu<sup>2+</sup> detection.
The RAA-Cas12a-MPXV assay via fluorescence reader and lateral flow strip.
Heparin is a highly sulfated linear glycosaminoglycan that used as an anticoagulant to prevent and treat thrombotic diseases. Herein, we find heparin specifically inhibits the activation of Cas12 protein through competitive binding crRNA Cas12. Studies illustrate heparin's high molecular weight strong negative charge are critical parameters for its inhibitory effect. This unexpected finding was engineered detection heparin, affording low limit 0.36 ng/mL fluorometric quantification. We...
Cancer cases have reached an all-time high in the current era.
Multiple studies have investigated the role of blood circulating proteins in COVID-19 disease using Olink affinity proteomics platform. However, study inclusion criteria and sample collection conditions varied between studies, leading to sometimes incongruent associations. To identify most robust protein markers underlying pathways that are relevant under all conditions, it is essential replicate widely. Here we combined profiles two newly recruited (N=68 N=98) with those three previously...
Magnesium alloys containing biocompatible components show tremendous promise for applications as temporary biomedical devices. However, to ensure their safe use biodegradeable implants, it is essential control corrosion rates. In concentrated Mg alloys, a microgalvanic coupling between the α-Mg matrix and secondary precipitates exists which results in increased rate. To address this challenge, we engineered microstructure of biodegradable Mg-Zn-RE-Zr alloy by friction stir processing (FSP),...
A fluorogenic reporter integrating a DNA–Cu nanocluster and Exo I was developed for CRISPR/Cas12a-based SARS-CoV-2 detection with minimized background signals.