A5064873511- Molecular Sensors and Ion Detection
- Luminescence and Fluorescent Materials
- Advanced Nanomaterials in Catalysis
- Nanoplatforms for cancer theranostics
- Electrochemical sensors and biosensors
- Sulfur Compounds in Biology
- Advanced biosensing and bioanalysis techniques
- Metal-Organic Frameworks: Synthesis and Applications
- Cholinesterase and Neurodegenerative Diseases
- Advanced Fluorescence Microscopy Techniques
- Mitochondrial Function and Pathology
- Carbon and Quantum Dots Applications
- Click Chemistry and Applications
- Lipid Membrane Structure and Behavior
- Analytical Chemistry and Sensors
- Nanocluster Synthesis and Applications
- Proteoglycans and glycosaminoglycans research
- Photoreceptor and optogenetics research
- Redox biology and oxidative stress
- Dendrimers and Hyperbranched Polymers
- Biotin and Related Studies
- Carbohydrate Chemistry and Synthesis
- Fluid Dynamics and Heat Transfer
- Lanthanide and Transition Metal Complexes
- Glycosylation and Glycoproteins Research
Nanjing Normal University
2020-2025
Esslingen University of Applied Sciences
2024
Westlake University
2022-2023
Southeast University
2016-2020
Southeast University
2016
University of Stuttgart
2015
Tohoku University
1995-2003
Abstract Fluorescence lifetime imaging has been a powerful tool for biomedical research. Recently, fluorescence lifetime‐based multiplexing expanded channels by using probes that harbor the same spectral and distinct excited state lifetime. While it is desirable to control of any given fluorescent probes, rational lifetimes remains challenge. Herein, we chose boron dipyrromethene (BODIPY) as model system provided chemical strategies regulate its derivatives with varying features. We find...
Near-infrared two-photon ClO<sup>−</sup> fluorescent probe based on the desulfurization reaction of thiosemicarbazide group.
Abstract Aberrant protein aggregation leads to various human diseases, but little is known about the physical chemical properties of these aggregated proteins in cells. Herein, we developed a boron‐dipyrromethene (BODIPY)‐based HaloTag probe, whose conjugation HaloTag‐fused allows us study aggregates using both fluorescence intensity and lifetime. Modulation BODIPY fluorophore reveals key structural features attain dual function. The optimized probe exhibits increased elongated lifetime...
Degenerative diseases are closely related to the changes of protein conformation beyond steady state. The development feasible tools for quantitative detection in cellular environment is crucial investigating process conformational variations. Here, we have developed a near-infrared AIE probe based on rhodamine fluorophore, which exhibits dual responses fluorescence intensity and lifetime local viscosity changes. Notably, computational analysis reveals that NRhFluors activation due...
Aggrephagy describes lysosomal transport and degradation of protein aggregates via cellular macroautophagy, a key mechanism to prevent neurodegenerative diseases. Here, we develop dual-probe method visualize the aggrephagy process resolve its viscosity heterogeneity using fluorescence lifetime imaging (FLIM). The system consists (1) near-infrared targeting FLIM probe (Lyso-P1) that is derived from rhodamine scaffold with tailored p
A novel near-infrared emission triphenylamine-BODIPY dendron for Hg<sup>2+</sup> and Fe<sup>3+</sup> detection, fluorescent nanoparticle living cell imaging.
In this work, a red emission fluorescent probe CBZ-BOD@zeolitic imidazolate framework-8 (ZIF-8) was fabricated based on metal–organic frameworks (MOFs) for detecting carboxylesterase 1 (CES1). The small molecule CBZ-BOD first synthesized and then used to prepare the functionalized MOF material. ZIF-8 chosen as an encapsulation shell improve detection properties of CBZ-BOD. Using unique porous materials, ultrasensitive quantification CES1 chlorpyrifos successfully realized. low limit high...
Photodynamic therapy (PDT) is a promising noninvasive treatment that has drawn great attention. However, the hypoxic environment in tumors seriously limits therapeutic effect of oxygen-dependent chemicals and PDT. Herein, versatile nanocomposite DF-BODIPY@ZIF-8 with oxygen-generating ability was developed based on zeolitic imidazolate framework-8 (ZIF-8) by loading near-infrared photosensitizer DF-BODIPY to overcome hypoxia-induced drug resistance cancer therapy. ZIF-8 can catalyze...
Mitochondria play a crucial role in maintaining cellular homeostasis, and the depolarization of mitochondrial membrane potential (MMP) is an important signal apoptosis. Additionally, protein misfolding aggregation are closely related to diseases including neurodegenerative diseases, diabetes, cancers. However, interaction between MMP changes disease-related was rarely studied. Herein, we report novel "turn-on" fluorescent probe MitoRhB that specifically targets mitochondria for Cu2+...
The number of cases Alzheimer's disease (AD) characterized by progressive amnestic syndrome is dramatically increased with population aging. It urgent to detect and diagnose this early. state amyloid-beta protein 1-42 (Aβ
A novel, acidic pH-activatable carbazolyl GFP chromophore analogue was designed for tracing lysosomal viscosity changes.