A5028779704- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- RNA Research and Splicing
- Cancer therapeutics and mechanisms
- Molecular Biology Techniques and Applications
- Bladder and Urothelial Cancer Treatments
- Lipid metabolism and biosynthesis
- Radiomics and Machine Learning in Medical Imaging
- Aquaculture disease management and microbiota
- Nitrogen and Sulfur Effects on Brassica
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Escherichia coli research studies
- DNA and Nucleic Acid Chemistry
- Vibrio bacteria research studies
- Ophthalmology and Visual Impairment Studies
- S100 Proteins and Annexins
- Pancreatic function and diabetes
- Retinal Diseases and Treatments
- Protein Hydrolysis and Bioactive Peptides
- Adipose Tissue and Metabolism
- Corneal surgery and disorders
- Cancer, Hypoxia, and Metabolism
Agency for Science, Technology and Research
2025
Genome Institute of Singapore
2025
Yangzhou University
2023-2024
Peking University
2024
Qingdao Agricultural University
2024
National Health and Family Planning Commission
2024
Model Animal Research Center
2024
Nanjing University
2024
State Key Laboratory of Pharmaceutical Biotechnology
2024
Center for Excellence in Molecular Cell Science
2024
Abstract Purpose: Chemoresistance and tumor relapse are the leading cause of deaths in bladder cancer patients. Bladder stem cells (BCSCs) have been reported to contribute these pathologic properties. However, molecular mechanisms underlying their self-renewal chemoresistance remain largely unknown. In current study, a novel lncRNA termed Low expressed Cancer Stem (lnc-LBCS) has identified explored BCSCs. Experimental Design: Firstly, we establish BCSCs model explore BCSCs-associated lncRNAs...
Castration-resistant prostate cancer (CRPC) that occurs after the failure of androgen deprivation therapy is leading cause deaths in patients. Thus, there an obvious and urgent need to fully understand mechanism CRPC discover novel therapeutic targets. Long noncoding RNAs (lncRNAs) are crucial regulators many human cancers, yet their potential roles molecular mechanisms poorly understood. In this study, we discovered lncRNA HOXD-AS1 highly expressed cells correlated closely with Gleason...
Abstract Epitranscriptomic RNA modifications constitute a critical gene regulatory component that can affect cancer progression. Among these, the N4-acetylcytidine (ac4C) modification, which is mediated by ac4C writer N-acetyltransferase 10 (NAT10), regulates stabilization of mRNA. Here, we identified modification induced upon cisplatin treatment and correlates with chemoresistance in bladder cancer. Both vitro vivo, NAT10 promoted cells enhancing DNA damage repair (DDR). Mechanistically,...
The prognosis for patients with bladder cancer (BCa) lymph node (LN) metastasis is poor, and it not improved by current treatments. Long noncoding RNAs (lncRNAs) are involved in the pathology of various tumors, including BCa. However, role Differentiation antagonizing non-protein coding RNA (DANCR) BCa LN remains unclear. In this study, we discover that DANCR was significantly upregulated tissues cases metastasis. expression positively correlated status, tumor stage, histological grade, poor...
Bladder cancer patients with lymph node (LN) metastasis have an extremely poor prognosis and no effective treatment. The alternative splicing of precursor (pre-)mRNA participates in the progression various tumors. However, precise mechanisms factors cancer-related variants LN bladder remain largely unknown. present study identified a factor, non-POU domain-containing octamer-binding protein (NONO), that was significantly downregulated tissues correlated status, tumor stage, prognosis....
Non-alcoholic fatty liver disease (NAFLD) is the primary chronic worldwide, mainly manifested by hepatic steatosis. Hepatic lipids may be derived from dietary intake, plasma free acid (FFA) uptake, or de novo lipogenesis (DNL). Currently, cellular and animal models of hepatocellular steatosis are widely used to study pathogenesis NAFLD investigate therapeutic agents. However, whether there differences between in vivo vitro mechanisms that cause lipid accumulation has not been reported. We...
Summary Lack of diversity and proportionate representation in genomics datasets databases contributes to inequity healthcare outcomes globally 1,2 . The relationships human with biological biomedical phenotypes are pervasive 3 , yet remain understudied, particularly a single-cell context. Here we present the Asian Immune Diversity Atlas (AIDA), multi-national RNA-sequencing (scRNA-seq) healthy reference atlas immune cells. AIDA comprises 1,265,624 circulating cells from 619 donors 6...
Abstract Background Overweight and obesity (OWOB) myopia have become two of the most important issues affecting health children adolescents worldwide. Despite recognition that school physical activity (PA) environment is a critical factor for preventing controlling overweight, (OWOB), in adolescents, research on OWOB as comorbidity remains unexplored, with evidence effective strategies still being inconclusive. Hence, this study aimed to assess prevalence progression comorbid OWOB/myopia...
METTL3, an RNA methyltransferase enzyme, exerts therapeutic effects on various cardiovascular diseases.Myocardial ischemia-reperfusion injury (MIRI) and subsequently cardiac fibrosis is linked to acute cardiomyocyte death or dysfunction induced by mitochondrial damage, particularly fission.Our research aims elucidate the potential mechanisms underlying actions of METTL3 in MIRI, with focus fission.When compared Mettl3 flox mice subjected knockout (Mettl3 Cko ) have reduced infarct size,...
Abstract Global warming attracts increasing public attention. However, in the past few decades, contribution of construction to greenhouse gas emissions is around 40% total emissions. The promotion waste remanufacturing faces challenges. application digital twins contributes tracking, recycling and management waste. This article reviews current research on Digital Twin remanufacturing, aiming at finding challenge opportunity solve it. Then, platform concept for provided as a solution...
Abstract Brown adipocytes share the same developmental origin with skeletal muscle. Here we find that a brown adipocyte-to-myocyte remodeling also exists in mature adipocytes, and is induced by prolonged high fat diet (HFD) feeding, leading to dysfunction. This process regulated interaction of epigenetic pathways involving histone DNA methylation. In demethylase UTX maintains persistent demethylation repressive mark H3K27me3 at Prdm16 promoter, expression. PRDM16 then recruits...
Nonalcoholic fatty liver disease (NAFLD) affects approximately a quarter of the population worldwide, and persistent overnutrition is one major causes. However, underlying molecular basis has not been fully elucidated, no specific drug approved for this disease. Here, we identify regulatory mechanism that reveals novel function Rab2A in progression NAFLD based on energy status PPARγ. The mechanistic analysis shows nutrition repletion suppresses phosphorylation AMPK-TBC1D1 signaling, augments...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 200 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
Post-amputation pain causes great suffering to amputees, but still no effective drugs are available due its elusive mechanisms. Our previous clinical studies found that surgical removal or radiofrequency treatment of the neuroma at axotomized nerve stump effectively relieves phantom afflicting patients after amputation. This indicated an essential role residual in formation chronic post-amputation (CPAP). However, molecular mechanism by which is involved and regulates CPAP a mystery. In this...
Bacteria have existed on Earth for billions of years, exhibiting ubiquity and involvement in various biological activities. To ensure survival, bacteria usually release secrete effector proteins to acquire nutrients compete with other microorganisms living space during long-term evolution. Consequently, developed a range secretion systems, which are complex macromolecular transport machines responsible transporting across the bacterial cell membranes. Among them, one particular system that...
Bellidifolin (BEL), a xanthone compound, has significant therapeutic effectiveness in cardiac diseases such as arrhythmias. However, BEL is limited clinical applications by its hydrophobicity. In this work, we used the active pharmaceutical ingredient (API), and polyethylene glycol 15-hydroxy stearate (Kolliphor HS15) carrier to prepare nano-micelles solvent-volatilization method. According an analysis differential scanning calorimetry (DSC), was successfully encapsulated HS15 with 90%...