A5102698186- Nutrition and Health in Aging
- Frailty in Older Adults
- Immune Cell Function and Interaction
- Medicinal Plants and Bioactive Compounds
- T-cell and B-cell Immunology
- Health Systems, Economic Evaluations, Quality of Life
- Urban Green Space and Health
- Single-cell and spatial transcriptomics
- Body Composition Measurement Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Circadian rhythm and melatonin
- Telomeres, Telomerase, and Senescence
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Galectins and Cancer Biology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Colorectal Cancer Treatments and Studies
- Stress Responses and Cortisol
- Clinical Nutrition and Gastroenterology
- Health, psychology, and well-being
- Protein Tyrosine Phosphatases
- Alzheimer's disease research and treatments
- Acupuncture Treatment Research Studies
- Cerebral Palsy and Movement Disorders
- Olfactory and Sensory Function Studies
Agency for Science, Technology and Research
2014-2025
Singapore Immunology Network
2014-2025
The effect of horticultural therapy (HT) on immune and endocrine biomarkers remains largely unknown. We designed a waitlist-control randomized controlled trial to investigate the effectiveness HT in improving mental well-being modulating biomarker levels. A total 59 older adults was recruited, with 29 randomly assigned intervention 30 waitlist control group. participants attended weekly sessions for first 3 months monthly subsequent months. Biological psychosocial data were collected....
Chronic systematic inflammation and reduced immune system fitness are considered potential contributing factors to the development of age-related frailty, but underlying mechanisms poorly defined. This exploratory study aimed identify frailty-related inflammatory markers immunological phenotypes in a cohort community-dwelling adults aged ≥ 55 years. Frailty was assessed using two models, Index categorical phenotype, correlated with levels circulating biomarkers senescence cell subsets. We...
The effects of fasting on health in non-human models have been widely publicised for a long time and emerging evidence support the idea that these can be applicable to human practice. In an open label longitudinal follow-up, cohort 78 adult men (aged 20 85 years) who fasted 29 consecutive days from sunrise sunset (16 h fasting—referred as recurrent circadian fasting) Pakistan, were studied. primary outcomes study was weight loss/recovery associated changes blood pressure circulating levels...
Immune adaptation with aging is a major of health outcomes. Studies in humans have mainly focus on αβ T cells while γδ been neglected despite their role immunosurveillance. We investigated the impact cell subsets phenotypes, functions, senescence and molecular response to stress.Peripheral blood young old donors Singapore used assess phenotype, functional capacity, proliferation capacity gene expression various subsets. Peripheral mononuclear from apheresis cones characterize telomere...
Evidence suggests the pivotal contribution of nutrition as a modifiable risk factor for sarcopenia. The present cross-sectional study characterized nutritional and metabolic profile sarcopenia through an extensive exploration wide array blood biomarkers related to muscle protein metabolism transcriptomic signatures in community-dwelling elderly adults. Among 189 older individuals with mean age 73.2 years, was diagnosed according Asian Working Group Sarcopenia criteria based on appendicular...
Summary Lack of diversity and proportionate representation in genomics datasets databases contributes to inequity healthcare outcomes globally 1,2 . The relationships human with biological biomedical phenotypes are pervasive 3 , yet remain understudied, particularly a single-cell context. Here we present the Asian Immune Diversity Atlas (AIDA), multi-national RNA-sequencing (scRNA-seq) healthy reference atlas immune cells. AIDA comprises 1,265,624 circulating cells from 619 donors 6...
Elderly individuals have an eroded immune system but whether senescence is implicated with the development of frailty unknown. The underlying mechanisms and link between markers physical not well established.We explored association specific T-cell subset differentiation on CD4+ CD8+ cells (CD28-, CD27- CD57+) risk profile (inverted CD4/CD8 ratio <1) among 421 participants who were frail (N=32), prefrail (N=187) robust (N=202) in Singapore Longitudinal Ageing Study cohort.In ordinal logistic...
Abstract Background Immune responses are generally impaired in aged mammals. T cells have been extensively studied this context due to the initial discovery of their reduced proliferative capacity with aging. The decreased involve altered signaling events associated early steps cell activation. underlying causes these changes not fully understood but point alterations assembly machinery for Here, we tested hypothesis that pool elderly subjects displayed functional capacities negative...
There is little understanding of the outcomes associated with active lifestyle interventions for sarcopenia among older persons.To determine association 6-month multidomain (physical exercise, nutritional enhancement, cognitive training, combined treatment, and standard care) change in status physical function adults 65 years older.Post hoc secondary analysis a parallel-group randomized clinical trial conducted from September 1, 2012, to 2014, at community centers providing services elderly...
Abstract Sarcopenia, a core feature of the physical frailty syndrome, is characterized by multisystem physiological dysregulation. No study has explored qualitatively hierarchical network relationships among different dysregulated pathways involved in pathogenesis sarcopenia. We used 40 blood biomarkers belonging to community‐dwelling prefrail and frail older persons derive measures multiple pathways, structural equation modeling generate path models dysregulations associated with muscle...
Biochemical processes have been associated with the pathogenesis of mild cognitive impairment (MCI) and dementia, including chronic inflammation, dysregulation membrane lipids disruption neurotransmitter pathways. However, research investigating biomarkers these in MCI remained sparse inconsistent. To collect fresh evidence, we evaluated performance several potential markers a cohort 57 patients cognitively healthy controls. showed obviously increased levels plasma TNF-α (p = 0.045)...
Few studies have comprehensively described changes in blood biomarkers of the physiological responses underlying sarcopenia reduction associated with lifestyle interventions. In this study, we performed secondary analyses data a randomized controlled trial multi-domain interventions (6-month duration physical exercise, nutritional enrichment, cognitive training, combination and standard care control) among 246 community-dwelling pre-frail frail elderly, aged ≥65 years, without sarcopenia....
// Crystal Tze Ying Tan 1 , Kilian Wistuba-Hamprecht 2,3 Weili Xu 1,4 Ma Schwe Zin Nyunt 5 Anusha Vasudev Bernett Teck Kwong Lee Graham Pawelec 2 Kia Joo Puan Olaf Rotzschke Pin Ng and Anis Larbi 1,4,6 Singapore Immunology Network (SIgN), Agency for Science Technology Research (A*STAR), Biopolis, Department of Internal Medicine II, Centre Medical Research, University Center, Tübingen, Germany 3 Dermatology, 4 School Biological Sciences, Nanyang Technological University, Gerontology...
Previous studies have reported that elderly with mild-cognitive impairment (MCI) who underwent short periods of mindfulness interventions showed improvement cognition, albeit the results were not significant due to small sample sizes. There is a lack randomized controlled trial intervention on MCI. Furthermore, there paucity evidence effects MCI patients as measured by inflammatory biomarkers. We hypothesized our Mindful Awareness Practice (MAP) could improve cognition and modulate stress...
Human evidence for the role of continuous antigenic stimulation from persistent latent infections in frailty is limited. We conducted a nested case-control study (99 deceased and 43 survivors) participants aged 55 above longitudinal ageing cohort followed up 2003 to 2017. Using blood samples baseline data collected 2003-2004, we examined association pathogenic load (PL) count seropositivity 10 microbes (viruses, bacteria mycoplasma) with cumulated deficit-frailty index (CD-FI) physical (PF)...
Abstract Background Lifelong accumulation of latent or persistent repeated infections may be a contributing factor to the deterioration physical and cognitive function associated with functional aging, but evidence is limited biological underpinnings are unclear. Methods We profiled seropositivity for common viral, bacterial, plasmodial pathogens local importance in community-living older adults 2 studies involving 745 (mean age 67.0, SD: 7.7 years), 142 72.7, 8.3 years). Pathogen load was...
In 2014, the residents aged 65 and above comprised 10.5% of population in Singapore. By year 2030, this number was projected to triple. Singaporean elderly population, social isolation is one main factors affecting prevalence depressive symptoms. regard, we proposed Horticultural Therapy (HT), which employs gardening parks visits, enhance psychological well-being. This a pilot randomized controlled trial Singapore examine effects HT on both psychometric measures biomarkers older adults. We...
Background: Multi-system physiological dysregulation (PD) may represent a biological endo-phenotype of clinical frailty. We investigated the co-occurrence PD with physical frailty and its contributions to known impact on adverse health outcomes. Methods: Data 2,725 participants from Singapore Longitudinal Aging Studies (SLAS-2), included baseline measures derived Mahalanobis distance (Dm) value 23 blood biomarkers. analyzed their concurrent association impacts 9-year mortality, MMSE...
<title>Abstract</title> Microsatellite stable (MSS) colorectal cancers (CRC) are largely unresponsive to immune checkpoint inhibition (ICI), prompting investigation into strategies enhance sensitivity. The MAYA trial, which utilized temozolomide (TMZ) in MGMT-silenced MSS mCRC, hypothesized that TMZ-induced hypermutation could sensitize tumors ICI. This phase II trial met its primary endpoint, demonstrating durable clinical responses with TMZ combined ipilimumab and nivolumab. To elucidate...
There is currently a paucity of research examining biomarkers in Horticultural Therapy (HT) studies. We proposed this pilot randomized controlled trial (RCT) Singapore to investigate the effects HT on elderly. hypothesized that could improve levels psychoneuroimmunological markers participants. Per inclusion and exclusion criteria, 69 community-dwelling elderly were recruited from TaRA@JP. Participants into either active treatment or waitlist control arms. programmes conducted weekly for...
There is currently a paucity of research examining biomarkers in Horticultural Therapy (HT) studies. We proposed this pilot randomized controlled trial (RCT) Singapore to investigate the effects HT on elderly. hypothesized that could improve levels psychoneuroimmunological markers participants. Per inclusion and exclusion criteria, 69 community-dwelling elderly were recruited from TaRA@JP. Participants into either active treatment or waitlist control arms. programmes conducted weekly for...
Studies in human aging mainly focus on αβ T cells while γδ have been neglected despite their role immunosurveillance. In this study, we investigated and its subsets (i.e. Vδ1 , Vδ2 DN (γδ Vδ1-Vδ2-)) by deep immunophenotyping. Our data shows that peripheral are differentially susceptible to life-long stresses against all other cells. Using cytomegalovirus history (the main confounding factor immune-aging studies) as immunological models via functional assays, telomere length determination,...
With the immense challenges population aging poses to healthcare, novel primary intervention facilitate compression of morbidity is imperative. One prominent risk factors for developing dementia immunological ageing or immunosenescence, characterized by increased chronic low-grade inflammation, resulting in T cell exhaustion and senescence. Contact with nature has been shown boost immunity older adults may be promoted form Horticultural Therapy (HT). However, there a scarcity HT studies...
Abstract Background Few randomized controlled trials investigated the effects of mindfulness intervention on older adults diagnosed with mild cognitive impairment (MCI). Specifically, there has been a scarcity literature potential benefit biomarker for AD hallmark. Thus, we conducted secondary analysis bio‐banked salivary samples pilot trial, examining whether Mindful Awareness Practice (MAP) improved Aβ‐42 levels in MCI. Method 55 community‐dwelling MCI were into either treatment arm, MAP,...