A5021881113- Muscle metabolism and nutrition
- Diet and metabolism studies
- Exercise and Physiological Responses
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Muscle Physiology and Disorders
- Dietary Effects on Health
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Circadian rhythm and melatonin
- Sports Performance and Training
- Metabolism, Diabetes, and Cancer
- Cardiovascular and exercise physiology
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Regulation of Appetite and Obesity
- Nutrition, Genetics, and Disease
- Body Composition Measurement Techniques
- Pancreatic function and diabetes
- Sirtuins and Resveratrol in Medicine
- Child Nutrition and Water Access
- Clinical Nutrition and Gastroenterology
- Consumer Attitudes and Food Labeling
- Pomegranate: compositions and health benefits
- Diet, Metabolism, and Disease
- Digestive system and related health
Australian Catholic University
2023-2025
Institute of Social and Preventive Medicine
2019-2025
University of Bern
2019-2025
Nestlé (Switzerland)
2013-2024
Nestlé Health Science (United States)
2021
Plymouth Marjon University
2017-2019
Nestlé (China)
2018
University of Thessaly
2014-2017
University of Toronto
2016
McMaster University
2016
We determined the effects of intravenous infusion amino acids (AA) at serum insulin 5, 30, 72, and 167 mU/l on anabolic signaling, expression ubiquitin-proteasome components, protein turnover in muscles healthy young men. Tripling AA availability 5 doubled incorporation [1-(13)C]leucine [i.e., muscle synthesis (MPS), P < 0.01] without affecting rate leg breakdown (LPB; appearance d(5)-phenylalanine). While keeping constant, increasing to 30 halved LPB (P 0.05) further inhibition higher...
Abstract Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD + ) levels are hallmarks of skeletal muscle ageing sarcopenia 1–3 , but it is unclear whether these defects result from local changes or can be mediated by systemic dietary cues. Here we report a functional link between circulating the natural alkaloid trigonelline, which structurally related to nicotinic acid 4 NAD health in multiple species. In humans, serum trigonelline reduced with correlate positively...
Circadian regulation of transcriptional processes has a broad impact on cell metabolism. Here, we compared the diurnal transcriptome human skeletal muscle conducted serial biopsies in vivo with profiles myotubes synchronized vitro. More extensive rhythmic transcription was observed to vitro culture as large part mRNA rhythmicity lost siRNA-mediated clock disruption primary significantly affected expression ~8% all genes, glucose homeostasis and lipid Genes involved GLUT4 expression,...
Strategies to enhance weight loss with a high fat-to-lean ratio in overweight/obese older adults are important since lean could exacerbate sarcopenia. We examined how dietary protein distribution affected muscle synthesis during energy balance (EB), restriction (ER), and plus resistance training (ER + RT). A 4-wk ER diet was provided men (66 ± 4 yr, 31 5 kg/m 2 ) who were randomized either balanced (BAL: 25% daily protein/meal × 4) or skewed (SKEW: 7:17:72:4% protein/meal; n = 10/group)...
Significance Our experiments provide the analysis of lipid metabolite circadian oscillations in a cellular system synchronized vitro, suggesting cell-autonomous diurnal changes profiles independent feeding. Moreover, our work represents comprehensive comparison between composition human skeletal muscle derived from sedentary healthy adults, receiving hourly isocaloric solutions, and primary myotubes cultured vitro. A substantial number metabolites, particular membrane lipids, exhibited...
Daily energy restriction more effectively reduces body fat content than alternate-day fasting, with no evidence of fasting-specific health benefits.
Evidence suggests the pivotal contribution of nutrition as a modifiable risk factor for sarcopenia. The present cross-sectional study characterized nutritional and metabolic profile sarcopenia through an extensive exploration wide array blood biomarkers related to muscle protein metabolism transcriptomic signatures in community-dwelling elderly adults. Among 189 older individuals with mean age 73.2 years, was diagnosed according Asian Working Group Sarcopenia criteria based on appendicular...
Single-leg cycling may enhance the peripheral adaptations of skeletal muscle to a greater extent than double-leg cycling. The purpose current study was determine influence 3 wk high-intensity single- and cycle training on markers oxidative potential metabolism exercise performance. In crossover design, nine trained cyclists (78 ± 7 kg body wt, 59 5 ml·kg −1 ·min maximal O 2 consumption) performed an incremental test 16-km time trial before after counterweighted single-leg (2 sessions per...
To investigate the effects of short-term, reduced-volume sprint interval training (SIT) compared to traditional exercise recommendations (TER) in sedentary obese men.Sixteen subjects [37.8 ± 5.8 years; body mass index (BMI) 32.8 4.7 kg/m(2)] were randomly allocated 2 weeks either SIT (6 sessions 8-12 × 10 s sprints) or TER [10 30 min at 65% peak oxygen consumption (VO(2peak))] cycle exercise. Fasting plasma glucose, insulin, non-esterified fatty acids (NEFA), homeostasis model assessment...
Key points Strategies to enhance the loss of fat while preserving muscle mass during energy restriction are great importance prevent sarcopenia in overweight older adults. We show for first time that integrated rate synthesis numerous individual contractile, cytosolic and mitochondrial skeletal proteins was increased by resistance training (RT) unaffected dietary protein intake pattern free‐living, obese men. observed a correlation between synthetic rates muscle‐derived obtained serum...
Polyphenolic plant extracts have demonstrated anti-inflammatory and anti-catabolic effects in vitro, however their meaningful translation into humans remains elusive. Urolithin A (UA), a gut-derived metabolite of ellagitannins, has shown promise for improving muscle function metabolic health rodent models. This study aimed to explore the impact UA on insulin anabolic sensitivity human skeletal cells. Primary myogenic cultures were derived from biopsies eight healthy adults. After...
Abstract: Skeletal muscle regeneration is a cardinal feature of pathologies and crucial for post-exercise recovery traumatic sports injuries. Regeneration damaged in humans prolonged process accompanied by pain physical dysfunction, highlighting the unmet need effective interventions to accelerate regenerative process. Through cellular preclinical models, we have previously identified nicotinamide (NAM) pyridoxine (PN) as potent stimulators Muscle Stem Cells (MuSCs). Herein investigated if...
Physical strength is associated with improved health outcomes in children. Heavier children tend to have lower functional and mobility. activity can increase children’s strength, but it unknown how different types of electronic media use impact physical strength. Data from the NHANES National Youth Fitness Survey (NNYFS) ages 6–15 were analyzed this study. Regression models conducted determine if screen-based sedentary behaviors (television viewing time, computer/video game time) measures...
Commencing selected workouts with low muscle glycogen availability augments several markers of training adaptation compared undertaking the same sessions normal content. However, reduces capacity to perform high-intensity (>85% peak aerobic power (VO2 peak)) endurance exercise. We determined whether a dose caffeine could partially rescue reduction in maximal self-selected output observed when individuals commenced interval (LOW) (NORM) availability.Twelve endurance-trained...
The effects of protein supplementation on performance recovery and inflammatory responses during a simulated one-week in-season microcycle with two games (G1, G2) performed three days apart were examined. Twenty football players participated in trials, receiving either milk concentrate (1.15 0.26 g/kg game training days, respectively) (PRO) or an energy-matched placebo (1.37 0.31 carbohydrate (PLA) according to randomized, repeated-measures, crossover, double-blind design. Each trial...
Abstract The ubiquitin–proteasome system (UPS) is the main cellular proteolytic responsible for degradation of normal and abnormal (e.g. oxidised) proteins. Under catabolic conditions characterised by chronic inflammation, UPS activated resulting in proteolysis, muscle wasting impaired function. Milk proteins provide sulphur-containing amino acid have been proposed to affect inflammation. However, response aseptic inflammation protein supplementation largely unknown. aim this study was...