A5040690419- Diet and metabolism studies
- Muscle metabolism and nutrition
- Dietary Effects on Health
- Pharmaceutical Practices and Patient Outcomes
- Cardiac Imaging and Diagnostics
- Adipose Tissue and Metabolism
- Cardiovascular Function and Risk Factors
- Physical Activity and Health
- Cardiac electrophysiology and arrhythmias
- Inflammatory Bowel Disease
- Birth, Development, and Health
- Trace Elements in Health
- Obesity, Physical Activity, Diet
- Microscopic Colitis
- Diabetes Management and Research
- Thyroid Cancer Diagnosis and Treatment
- Atrial Fibrillation Management and Outcomes
- Gestational Diabetes Research and Management
- Regulation of Appetite and Obesity
- Statistical Methods in Clinical Trials
- Sexual function and dysfunction studies
- Diabetes Treatment and Management
- Cardiovascular and exercise physiology
- Acute Myocardial Infarction Research
- Nutritional Studies and Diet
University of Bath
2017-2025
University of Colorado Anschutz Medical Campus
2017-2025
ZOE (United Kingdom)
2023-2024
King's College London
2024
Colorado School of Public Health
2017-2023
University of Colorado Denver
2023
University of Colorado System
2019
Oxford Brookes University
2018
University of Massachusetts Boston
2014
Center for Drug Evaluation and Research
2013
Abstract Controlled clinical trials of the treatment acute myocardial infarction offer a unique opportunity for study potential influence on outcome bias in assignment. A group 145 papers was divided into those which randomization process blinded (57 papers), it may have been unblinded (45 and controls were selected by nonrandom (43 papers). At least one prognostic variable maldistributed (P<0.05) 14.0 per cent blinded-randomization studies, 26.7 unblinded-randomization 58.1 nonrandomized...
Abstract Since the last comprehensive review of anticoagulation in acute myocardial infarction four additional randomized control trials have been reported. The overwhelming majority all favored anticoagulation. Rates thromboembolism were higher control, and hemorrhagic complications anticoagulated group. Pooling gives mean case fatality rates 19.6 per cent for 15.4 group, a relative reduction 21 (P<0.05 or <0.001, depending on analytic method). Five six reported "no effect" because...
We reexamined the association between corticosteroid therapy and subsequent peptic ulceration or gastrointestinal hemorrhage by pooling data from 71 controlled clinical trials in which patients were randomized to systemic corticosteroids (or ACTH) nonsteroid therapy. Of 3064 steroid-treated evaluated for ulcer, 55 (1.8 per cent) had ulcers, as compared with 23 of 2897 controls (0.8 (relative risk, 2.3; 95 cent confidence interval, 1.4 3.7). 3135 hemorrhage, 78 (2.5 bleeding, 48 2976 (1.6...
Abstract To evaluate the use of antibiotics given prophylactically in colon surgery, we examined 26 trials published from 1965 to 1980 which patients various antibiotic regimens were compared with controls no treatment. In 22 (85 per cent these trials) reduced postoperative wound infection (P<0.05 14). Combining results 1975 reveals a 95 confidence interval for true difference rates 14±6 (36 control group vs. treatment group) and death 6.7±4.4 (11.2 4.5 group). Yet employing groups continue...
The authors estimated cancer risk among 579 patients hospitalized with Crohn's disease between 1960–1976 by calculating the ratios of observed number cancers (O) in our hospital sample to expected (E) based on age- and sex-specific rates a standard population. then compared these O/E similarly calculated 267 ulcerative colitis. colorectal was significantly increased (O/E = 6.9, P< 0.001). This increase similar magnitude that found left-sided colitis 8.6, 0.001) but much less than universal...
Abstract Linear polyphenylene sulfide has been synthesized by the condensation polymerization of alkali metal salts p ‐halothiophenols. The monomers investigated included lithium, sodium and potassium ‐bromothiophenol ‐fluoro‐, ‐chloro‐, ‐bromo‐, ‐iodothiophenol. mass polymerizations these were carried out below melting points appear to involve a solid state reaction. Rate measurements made on in pyridine model propagation In both cases, order reactivities was I > Br F ∼ Cl, reaction, K...
The case histories of 1961 patients with inflammatory bowel disease (IBD), 1227 Crohn's (CD) and 734 ulcerative colitis (UC), have been studied for the incidence extraintestinal malignant neoplasms. There were 54 cancers in 51 patients: 28 CD 23 UC; 25 men 26 women. 9 breast, 7 skin, 15 reticuloendothelial, 11 genitourinary, 3 lung, perianal, 2 pancreatic islet cell, several miscellaneous cancers. number patient-years from onset to last date follow-up was calculated women each form IBD....
Cancer occurred in 28 of 579 patients (4.8%) with Crohn's disease (CD) and 30 267 (11.2%) ulcerative colitis (UC) admitted to the Mount Sinai Hospital between 1960--1976. The proportion cancers that were extraintestinal was greater CD than UC (43 vs. 12%), as gastrointestinal arose apparently normal bowels (33 4%). incidence cancer increase duration both UC, but absolute rates three times higher UC. For cancer, on other hand, there less correlation increasing disease, no frequency CD....
Using a balanced experimental design, 30 regularly cycling woman not using oral contraceptives, aged 20 to years, were assessed in laboratory setting during the follicular, ovulatory, and luteal phases. Sexual arousal was measured by self-report photoplethysmographic recordings of vaginal vasocongestion. Plasma estradiol, progesterone, testosterone determined radioimmunoassay. There marked consistent individual differences among women their sexual arousability. Subjective reports did differ...
Daily energy restriction more effectively reduces body fat content than alternate-day fasting, with no evidence of fasting-specific health benefits.
ABSTRACT Studies have suggested that phytochemicals in green tea systemic anti-inflammatory and neuroprotective effects. However, the mechanisms behind these effects are poorly understood, possibly due to differential metabolism of resulting from variations gut microbiome composition. To unravel this complex relationship, our team utilized a novel combined analysis metabolomics approach applied low complexity (LCM) human colonized (HU) gnotobiotic mice treated with an acute dose powdered...
Venous thromboembolism (VTE) is a clinically important complication for both hospitalised and ambulatory cancer patients. In the current study, frequency, demographics risk (according to tumour site) of VTE were examined among patients seen at outpatient DVT (deep-vein thrombosis) clinics. Of 10,015 cases, 1,361 diagnosed with cancer, an overall rate cancer-associated 13.6% in this population. Patients significantly older than cancer-free cases (66.4 +/- 12.7 vs. 58.8 18.5 years; p<0.0001)....
In an effort to further elucidate the mode of catalysis metal salts in urethane reaction, monofunctional compounds various types and polyfunctional alcohols were allowed react with either phenyl isocyanate or tolylene diisocyanate (80/20 mixture 2,4- 2,6-isomers) under by a tertiary amine one two salts. With compounds, relative activity catalysts was cobaltous stearate > stannous 2-ethylhexoate triethylenediamine. however, positions this series are reversed. Evidence is presented based upon...
Per- and polyfluoroalkyl substances (PFAS) are environmentally persistent chemicals widely detected in women of reproductive age. Prenatal PFAS exposure is associated with adverse health outcomes children. We hypothesized that DNA methylation changes may result from prenatal be linked to offspring cardio-metabolic phenotype. estimated associations umbilical cord blood. evaluated at selected sites neonatal indicators. Among 583 mother-infant pairs a prospective cohort, five were quantified...
ECG changes were assessed in 15 patients whom intracoronary streptokinase recanalized a totally occluded left anterior descending artery during acute myocardial infarction. These results compared retrospectively with those 22 comparable conventionally treated who underwent catheterization the stage of Before angiography no significant differences found sum ST elevation (sigma increase V1-V6), R waves RV1-V6), or number Q (nQV1-V6) leads V1 through V6. sigma V1-V6 was significantly lower...
To assess the reliability of erythrocytic sedimentation rate (ESR) as a measure clinical activity in inflammatory bowel disease, we analyzed correlations ESR with global assessment 77 patients varying extents Crohn's disease and ulcerative colitis. Analysis all 141 determinations showed highly significant correlation between mean score (r = 0.54, p < 0.001). 133 these when their was either mild, moderate, or severe some differences among certain categories. The highest ESRs were most...