A5000248029- Adipose Tissue and Metabolism
- Cardiovascular and exercise physiology
- Muscle metabolism and nutrition
- Diet and metabolism studies
- High Altitude and Hypoxia
- Muscle Physiology and Disorders
- Dietary Effects on Health
- Antioxidant Activity and Oxidative Stress
- Cardiovascular Effects of Exercise
- Respiratory Support and Mechanisms
- Extracellular vesicles in disease
- Fatty Acid Research and Health
- Regulation of Appetite and Obesity
- Pomegranate: compositions and health benefits
- Nutritional Studies and Diet
- Prenatal Screening and Diagnostics
- Genomics and Rare Diseases
- Cynara cardunculus studies
- Genetic Syndromes and Imprinting
- Heart Rate Variability and Autonomic Control
- Cardiovascular and Diving-Related Complications
Versus Arthritis
2019-2025
Queen's Medical Centre
2019-2025
University of Nottingham
2018-2025
Costello Medical Consulting (United Kingdom)
2025
University of Gloucestershire
2017
Daily energy restriction more effectively reduces body fat content than alternate-day fasting, with no evidence of fasting-specific health benefits.
Polyphenolic plant extracts have demonstrated anti-inflammatory and anti-catabolic effects in vitro, however their meaningful translation into humans remains elusive. Urolithin A (UA), a gut-derived metabolite of ellagitannins, has shown promise for improving muscle function metabolic health rodent models. This study aimed to explore the impact UA on insulin anabolic sensitivity human skeletal cells. Primary myogenic cultures were derived from biopsies eight healthy adults. After...
ABSTRACT Schinzel‐Giedion Syndrome (SGS) is an ultra‐rare, multisystem, genetic developmental disorder caused by gain‐of‐function pathogenic variants in the SETBP1 gene. No standard of care (SoC) recommendations currently exist. To assess expert opinion on SoC for individuals with SGS using a modified Delphi method. A multidisciplinary panel 21 experts from USA and Europe was assembled. Experts responded to two‐round questionnaire, subgroup participating virtual workshop, through which...
Abstract Myostatin negatively regulates skeletal muscle growth and appears upregulated in human obesity associated with insulin resistance. However, observations are confounded by ageing, the mechanisms responsible unknown. The aim of this study was to delineate between effects excess adiposity, resistance ageing on myostatin mRNA expression investigate causative factors using vitro models. An vivo cross-sectional analysis undertaken isolate adiposity per se expression. In studies employed...
The aim of this study was to determine the chronic (≥72 h postexercise) effects high-intensity interval training (HIIT) on postprandial lipemia and metabolic markers in healthy volunteers. Eight physically active young men (mean ± SD: age 22 3 yr, height 1.77 0.07 m, body mass 67.7 6.2 kg) underwent two 6-h mixed-meal tolerance tests resting vastus lateralis muscle biopsies before first session ≥72 after final 4 wk HIIT [16 sessions total; 10 × 60-s bouts cycling at 90% maximal oxygen uptake...
Intermittent exposure to hypoxia can lead improved endurance performance. Currently, it is unclear whether peripheral adaptions play a role in improving oxygen delivery and utilization following both training detraining. This study aimed characterize skeletal muscle blood flow (mBF), consumption (mV̇O2), perfusion adaptations i) 4-weeks handgrip hypoxic normoxic conditions, ii) Using randomised crossover design, 9 males completed 30-min four times week (14% FiO2 ~ 3250m altitude) conditions....
Obesity and insulin resistance are associated with an impaired sensitivity to anabolic stimuli such as dietary protein (anabolic resistance). Omega-3 polyunsaturated fatty acids (n-3 PUFA) may be protective against the deleterious effects of saturated (SFA) on resistance. However, contribution excess fat consumption interaction between SFA n-3 PUFA is not well studied.The primary aim this study was investigate oral pre-load, or without partial substitution fish oil (FO)-derived PUFA, indices...
The effects of intermittent hypoxic exposure (live low train high) on skeletal muscle oxygenation kinetics remain poorly understood. However, recent developments in technology have meant that the monitoring blood flow response to training is possible. PURPOSE: aim current study was determine whether handgrip dynamometry (HGD) normobaric hypoxia (14% FiO2) altered non-dominant flexor digitorum profundus (FDP) at rest and during exercise. METHODS: Following institutional ethical approval, 7...